Browsing NTNU Open by Author "Tylleskär, Ida"
Now showing items 1-9 of 9
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Naloksonnesespray – biotilgjengelighet og opptaksmønster i en fase 1-studie
Tylleskär, Ida; Skulberg, Arne Kristian; Nilsen, Turid; Skarra, Sissel; Dale, Ola (Journal article; Peer reviewed, 2019)Kameratredning med nalokson i nesespray kan forebygge dødsfall ved opioidoverdoser. For å få best mulig opptak av nalokson i nesen må sprayen gis med et lavt volum med høy medikamentkonsentrasjon. Målet med studien var å ... -
NTNU intranasal naloxone trial (NINA-1) study protocol for a double-blind, double-dummy, non-inferiority randomised controlled trial comparing intranasal 1.4 mg to intramuscular 0.8 mg naloxone for prehospital use
Skulberg, Arne Kristian; Tylleskär, Ida; Braarud, Anne-Cathrine; Dale, Jostein; Heyerdahl, Fridtjof; Mellesmo, Sindre; Valberg, Morten; Dale, Ola (Peer reviewed; Journal article, 2020)Abstract Introduction Intranasal naloxone is widely used to treat opioid overdoses. The advantage of nasal administration compared to injection lies in its suitability for administration by lay people as it is needless. ... -
Pharmacodynamics and arteriovenous difference of intravenous naloxone in healthy volunteers exposed to remifentanil
Tylleskär, Ida; Skulberg, Arne Kristian; Skarra, Sissel; Nilsen, Turid; Dale, Ola (Journal article; Peer reviewed, 2018)Purpose Pharmacodynamic studies of naloxone require opioid agonism. Steady state condition may be achieved by remifentanil TCI (target controlled infusion). Opioid agonism can be measured by pupillometry. It is not known ... -
The pharmacokinetic interaction between nasally administered naloxone and the opioid remifentanil in human volunteers
Tylleskär, Ida; Skarra, Sissel; Skulberg, Arne Kristian; Dale, Ola (Journal article; Peer reviewed, 2021)Purpose Remifentanil has been shown to increase the bioavailability of nasally administered naloxone. The aim of this study was to explore the nature of this observation. Methods We analysed samples from three pharmacokinetic ... -
Pharmacokinetics and -dynamics of intramuscular and intranasal naloxone: an explorative study in healthy volunteers
Skulberg, Arne Kristian; Tylleskär, Ida; Nilsen, Turid; Skarra, Sissel; Salvesen, Øyvind; Sand, Trond; Loftsson, Thorsteinn; Dale, Ola (Journal article; Peer reviewed, 2018)Purpose This study aimed to develop a model for pharmacodynamic and pharmacokinetic studies of naloxone antagonism under steady-state opioid agonism and to compare a high-concentration/low-volume intranasal naloxone ... -
Pharmacokinetics of a new, nasal formulation of naloxone
Tylleskär, Ida; Skulberg, Arne Kristian; Nilsen, Turid; Skarra, Sissel; Jansook, Phatsawee; Dale, Ola (Journal article; Peer reviewed, 2017)Purpose Nasal naloxone is wanted for bystander administration in opioid overdose and as a needle-free alternative for emergency medical personnel. Epidemiologic studies have indicated a therapeutic effect of bystander ... -
Pharmacokinetics of a novel, approved, 1.4-mg intranasal naloxone formulation for reversal of opioid overdose—a randomized controlled trial
Skulberg, Arne Kristian; Åsberg, Anders; Zare, Hasse Khiabani; Røstad, Hilde; Tylleskär, Ida; Dale, Ola (Peer reviewed; Journal article, 2019)Background and aims Intranasal (i.n.) naloxone is an established treatment for opioid overdose. Anyone likely to witness an overdose should have access to the antidote. We aimed to determine whether an i.n. formulation ... -
Prehospital naloxone administration – what influences choice of dose and route of administration?
Tylleskär, Ida; Gjersing, Linn; Bjørnsen, Lars Petter Bache-Wiig; Braarud, Anne-Cathrine; Heyerdahl, Fridtjof; Dale, Ola; Skulberg, Arne Kristian (Peer reviewed; Journal article, 2020)Background Amidst the ongoing opioid crisis there are debates regarding the optimal route of administration and dosages of naloxone. This applies both for lay people administration and emergency medical services, and in ... -
REBOARREST, resuscitative endovascular balloon occlusion of the aorta in non-traumatic out-of-hospital cardiac arrest: a study protocol for a randomised, parallel group, clinical multicentre trial
Brede, Jostein Rødseth; Skulberg, Arne Kristian; Rehn, Marius; Thorsen, Kjetil; Klepstad, Pål; Tylleskär, Ida; Farbu, Bjørn; Dale, Jostein; Nordseth, Trond; Wiseth, Rune; Krüger, Andreas Jørstad (Journal article; Peer reviewed, 2021)Background: Survival after out-of-hospital cardiac arrest (OHCA) is poor and dependent on high-quality cardiopulmonary resuscitation. Resuscitative endovascular balloon occlusion of the aorta (REBOA) may be advantageous ...