Browsing NTNU Open by Author "Tang, Wannan"
Now showing items 1-11 of 11
-
A novel approach for transcriptomic mapping of cortical astrocytes and neurons upon sustained local noradrenergic neuromodulation
Dahle, Maja (Master thesis, 2024)Noradrenalin (NA) er en essensiell nevromodulator for normal hjernefunksjon. Den viktigste kilden til noradrenalin (NA) i hjernen er Locus Coeruleus (LC), plassert i hjernestammen. NA frigjøres fra LC-nevroner gjennom både ... -
A novel approach to study the impact of reduced brain noradrenergic neuromodulation on transcriptome changes of cortical neurons and astrocytes
Fjeldstad, Synnøve Algrøy (Master thesis, 2024)Noradrenalin (NA) er eit viktig stoff som bidreg til å oppretthalde normal hjernefunksjon. NA er involvert i eit vidt spekter av funksjoner, mellom anna overgangar mellom ulike nivå av aktivitet i hjernen. Den viktigaste ... -
Alternative anesthesia of neonatal mice for global rAAV delivery in the brain with non-detectable behavioral interference in adults
Tang, Wannan; Zillmann, Uwe; Sprengel, Rolf (Peer reviewed; Journal article, 2020)Viral-transduced gene expression is the current standard for cell-type-specific labeling and cell tacking in experimental neuroscience. To achieve widespread gene expression, a viral delivery method to neonatal rodents was ... -
Astrocytic Ca2+ signaling is reduced during sleep and is involved in the regulation of slow wave sleep
Bojarskaite, Laura; Bjørnstad, Daniel Marelius; Pettersen, Klas; Cunen, Celine; Hermansen, Gudmund Horn; Åbjørsbråten, Knut Sindre; Chambers, Anna; Sprengel, Rolf; Vervaeke, Koen Gerard Alois; Tang, Wannan; Enger, Rune; Nagelhus, Erlend Arnulf (Peer reviewed; Journal article, 2020)Astrocytic Ca2+ signaling has been intensively studied in health and disease but has not been quantified during natural sleep. Here, we employ an activity-based algorithm to assess astrocytic Ca2+ signals in the neocortex ... -
Characterization of a GRAB-based ATP Sensor in the Mouse Cortex and Hippocampus
Jabeen, Aqsa (Master thesis, 2022)Abstract will be available on 2022-12-31 -
Deletion of aquaporin-4 improves capillary blood flow distribution in brain edema
Bordoni, Luca; Thorén, Anna Elisabeth; Gutiérrez-Jiménez, Eugenio; Åbjørsbråten, Knut Sindre; Bjørnstad, Daniel Marelius; Tang, Wannan; Stern, Mette; Østergaard, Leif; Nagelhus, Erlend Arnulf; Frische, Sebastian; Ottersen, Ole Petter; Enger, Rune (Peer reviewed; Journal article, 2023)Brain edema is a feared complication to disorders and insults affecting the brain. It can be fatal if the increase in intracranial pressure is sufficiently large to cause brain herniation. Moreover, accruing evidence ... -
Establishing Molecular Tools for Studying Noradrenergic Neuromodulation in Cortical Astrocytes
Lervold, Iril (Master thesis, 2024)Noradrenerge nevroner med cellekropper i locus coeruleus (LC) (NA-LC-systemet) spiller en nøkkelrolle i regulering av funksjoner som stressaktivering, oppmerksomhet og opphisselse, gjennom projeksjoner til mange ulike ... -
Impaired astrocytic Ca2+ signaling in awake-behaving Alzheimer’s disease transgenic mice
Åbjørsbråten, Knut Sindre; Skaaraas, Gry HE Syverstad; Cunen, Celine Marie Løken; Bjørnstad, Daniel Marelius; Binder, Kristin M Gullestad; Bojarskaite, Laura; Jensen, Vidar; Nilsson, Lars; Rao, Shreyas B.; Tang, Wannan; Hermansen, Gudmund Horn; Nagelhus, Erlend Arnulf; Ottersen, Ole Petter; Torp, Reidun; Enger, Rune (Peer reviewed; Journal article, 2022)Increased astrocytic Ca2+ signaling has been shown in Alzheimer’s disease mouse models, but to date no reports have characterized behaviorally induced astrocytic Ca2+ signaling in such mice. Here, we employ an event-based ... -
Increased membrane Ca<sup>2+</sup> permeability drives astrocytic Ca<sup>2+</sup> dynamics during neuronal stimulation at excitatory synapses
Hjukse, Jarand Berg; Fernández de la Puebla, Mario; Vindedal, Gry Fluge; Sprengel, Rolf; Jensen, Vidar; Nagelhus, Erlend Arnulf; Tang, Wannan (Peer reviewed; Journal article, 2023)Astrocytes are intricately involved in the activity of neural circuits; however, their basic physiology of interacting with nearby neurons is not well established. Using two-photon imaging of neurons and astrocytes during ... -
A loss-of-function mutation in human Oxidation Resistance 1 disrupts the spatial–temporal regulation of histone arginine methylation in neurodevelopment
Lin, Xiaolin; Wang, Wei; Yang, Mingyi; Damseh, Nadirah; Sousa, Mirta; Jacob, Fadi; lång, anna ulrika; Kristiansen, Elise; Pannone, Marco; Kissova, Miroslava; Almaas, Runar; Kusnierczyk, Anna; Siller, Richard; Shahrour, Maher; Al-Ashhab, Motee; Abu-Libdeh, Bassam; Tang, Wannan; Slupphaug, Geir; Elpeleg, Orly; Bøe, Stig Ove; Eide, Lars; Sullivan, Gareth John; Rinholm, Johanne Egge; Song, Hongjun; Ming, Guo-li; van Loon, Barbara; Edvardson, Simon; Ye, Jing; Bjørås, Magnar (Peer reviewed; Journal article, 2023)Background Oxidation Resistance 1 (OXR1) gene is a highly conserved gene of the TLDc domain-containing family. OXR1 is involved in fundamental biological and cellular processes, including DNA damage response, antioxidant ... -
Marking astrocytes in cortex and hippocampus of the mouse brain.
Khadka, Sukirty (Master thesis, 2024)Astrocytes are one of the most important non-neuronal cell types of the nervous system, which are playing an essential role in physiology and diseased states of the brain. However, many facets of the astrocytes are still ...