Blar i NTNU Open på forfatter "Sulheim, Einar"

Viser treff 1-20 av 27

    • Acoustic Cluster Therapy (ACT) and Induced Immune Response 

      Sripalan, Gopana (Master thesis, 2021)
      Abstract will be available on 2024-08-01

    • Cabazitaxel-loaded Poly(2-ethylbutyl cyanoacrylate) nanoparticles improve treatment efficacy in a patient derived breast cancer xenograft 

      Fusser, Markus; Øverbye, Anders; Pandya, Abhilash D.; Mørch, Ýrr Asbjørg; Borgos, Sven Even F.; Kildal, Wanja; Snipstad, Sofie; Sulheim, Einar; Fleten, Karianne Giller; Askautrud, Hanne Arenberg; Engebraaten, Olav; Flatmark, Kjersti; Iversen, Tore Geir; Sandvig, Kirsten; Skotland, Tore; Mælandsmo, Gunhild Mari (Journal article; Peer reviewed, 2018)
      The effect of poly(2-ethyl-butyl cyanoacrylate) nanoparticles containing the cytotoxic drug cabazitaxel was studied in three breast cancer cell lines and one basal-like patient-derived xenograft model grown in the mammary ...

    • Characterization of immune cell populations in syngeneic murine tumor models 

      Snipstad, Sofie; Bremnes, Frida; Haugum, Mats Dehli; Sulheim, Einar (Peer reviewed; Journal article, 2023)
      Immunocompetent murine models are important tools for preclinical evaluation of immunotherapies. Here, six different immunocompetent tumor models based on four different cell lines were characterized, including metastatic ...

    • Composite PACA Nanoparticle-Alginate Microspheres for Sustained Drug Delivery - Characterization, Optimization, In Vitro Drug Release and Cytotoxicity Studies 

      Einen, Caroline; Benjakul, Sopisa (Master thesis, 2018)

    • Contrast Enhanced Magnetic Resonance Imaging of Amyloid-β Plaques in a Murine Alzheimer's Disease Model 

      Sulheim, Einar; Widerøe, Marius; Bäck, Marcus; Nilsson, K Peter R; Hammarström, Per; Nilsson, Lars; Davies, Catharina de Lange; Åslund, Karl Olof Andreas (Journal article; Peer reviewed, 2023)
      Background: Early detection of amyloid-β (Aβ) aggregates is a critical step to improve the treatment of Alzheimer’s disease (AD) because neuronal damage by the Aβ aggregates occurs before clinical symptoms are apparent. ...

    • Cytotoxicity of poly(Alkyl cyanoacrylate) nanoparticles 

      Sulheim, Einar; Iversen, Tore Geir; To, Vu; Klinkenberg, Geir; Sletta, Håvard; Schmid, Ruth; Hatletveit, Anne Rein; Wågbø, Ane Marit; Sundan, Anders; Skotland, Tore; Sandvig, Kirsten; Mørch, Ýrr Asbjørg (Journal article; Peer reviewed, 2017)
      Although nanotoxicology has become a large research field, assessment of cytotoxicity is often reduced to analysis of one cell line only. Cytotoxicity of nanoparticles is complex and should, preferentially, be evaluated ...

    • Effect of acoustic cluster therapy (ACT®) combined with chemotherapy in a patient-derived xenograft mouse model of pancreatic cancer 

      Ng, Serina; Healey, Andrew J.; Sontum, Per Christian; Kvåle, Svein; Torp, Sverre Helge; Sulheim, Einar; Von Hoff, Daniel; Han, Haiyoung (Peer reviewed; Journal article, 2022)
      Pancreatic ductal adenocarcinomas respond poorly to chemotherapy, in part due to the dense tumor stroma that hinders drug delivery. Ultrasound (US) in combination with microbubbles has previously shown promise as a means ...

    • Extracellular vesicles in patients in the acute phase of psychosis and after clinical improvement: an explorative study 

      Tunset, Mette Elise; Haslene-Hox, Hanne; Bossche, Tim Van Den; Vaaler, Arne; Sulheim, Einar; Kondziella, Daniel (Peer reviewed; Journal article, 2020)
      Extracellular vesicles (EVs) are cell-derived structures that transport proteins, lipids and nucleic acids between cells, thereby affecting the phenotype of the recipient cell. As the content of EVs reflects the status of ...

    • Labeling nanoparticles: Dye leakage and altered cellular uptake 

      Snipstad, Sofie; Hak, Sjoerd; Baghirov, Habib; Sulheim, Einar; Mørch, Ýrr Asbjørg; Lelu, Sylvie; von Haartman, Eva; Bäck, Marcus; Nilsson, Peter R; Klymchenko, Andrey S; Davies, Ruth Catharina de Lange; Åslund, Andreas (Journal article, 2016)
      In vitro and in vivo behavior of nanoparticles (NPs) is often studied by tracing the NPs with fluorescent dyes. This requires stable incorporation of dyes within the NPs, as dye leakage may give a wrong interpretation of ...

    • Mechanisms of Cellular Uptake and Intracellular Degradation of Polymeric Nanoparticles 

      Sulheim, Einar (Master thesis, 2014)
      The effect of cancer therapy could be greatly improved by encapsulating existing drugs into nanoparticles. Nanoparticles can facilitate delivery of hydrophobic drugs with poor solubility in water, and allow you to target ...

    • Multi-modal characterization of vasculature and nanoparticle accumulation in five tumor xenograft models 

      Sulheim, Einar; Kim, Jana; van Wamel, Annemieke; Kim, Eugene; Snipstad, Sofie; Vidic, Igor; Grimstad, Ingeborg; Widerøe, Marius; Torp, Sverre Helge; Lundgren, Steinar; Waxman, David J.; Davies, Catharina de Lange (Journal article; Peer reviewed, 2018)
      Preclinical research has demonstrated that nanoparticles and macromolecules can accumulate in solid tumors due to the enhanced permeability and retention effect. However, drug loaded nanoparticles often fail to show increased ...

    • Nanomedicine and Sonopermeation in the Treatment of Cancer 

      Sulheim, Einar (Doctoral theses at NTNU;2019:98, Doctoral thesis, 2018)
      Treatment of cancer is an enormous challenge that involves multiple biological barriers and drugs with limited specificity, which makes treatment both ineffective and debilitating to the patient. One of the approaches that ...

    • Nanoparticle-stabilized microbubbles for multimodal imaging and drug delivery 

      Mørch, Ýrr Asbjørg; Hansen, Rune; Berg, Sigrid; Åslund, Andreas; Glomm, Wilhelm; Eggen, Siv; Schmid, Ruth; Johnsen, Heidi; Kubowicz, Stephan; Snipstad, Sofie; Sulheim, Einar; Hak, Sjoerd; Singh, Gurvinder; McDonagh, Birgitte Hjelmeland; Blom, Hans; Davies, Ruth Catharina de Lange; Stenstad, Per Martin (Journal article, 2015)
      Microbubbles (MBs) are routinely used as contrast agents for ultrasound imaging. The use of ultrasound in combination with MBs has also attracted attention as a method to enhance drug delivery. We have developed a technology ...

    • Quantification and Qualitative Effects of Different PEGylations on Poly(butyl cyanoacrylate) Nanoparticles 

      Åslund, Andreas; Sulheim, Einar; Snipstad, Sofie; von Haartman, Eva; Baghirov, Habib; Starr, Nichola; Løvmo, Mia Kvåle; Lelu, Sylvie; Scurr, David; Davies, Catharina De Lange; Schmid, Ruth; Mørch, Yrr Asbjørg (Journal article, 2017)
      Protein adsorption on nanoparticles (NPs) used in nanomedicine leads to opsonization and activation of the complement system in blood, which substantially reduces the blood circulation time of NPs. The most commonly used ...

    • Small variations in nanoparticle structure dictate differential cellular stress responses and mode of cell death 

      Szwed, Marzena; Sønstevold, Tonje; Øverbye, Anders; Engedal, Nikolai; Grallert, Beata; Mørch, Ýrr Asbjørg; Sulheim, Einar; Iversen, Tore Geir; Skotland, Tore; Sandvig, Kirsten; Torgersen, Maria Lyngaas (Peer reviewed; Journal article, 2019)
      For optimal exploitation of nanoparticles (NPs) in biomedicine, and to predict nanotoxicity, detailed knowledge of the cellular responses to cell-bound or internalized NPs is imperative. The final outcome of NP-cell ...

    • Smart cancer nanomedicine 

      van der Meel, Roy; Sulheim, Einar; Shi, Yang; Kiessling, Fabian; Mulder, Willem J.M.; Lammers, Twan (Peer reviewed; Journal article, 2019)
      Nanomedicines are extensively employed in cancer therapy. We here propose four strategic directions to improve nanomedicine translation and exploitation. (1) Patient stratification has become common practice in oncology ...

    • Sonopermeation Enhances Uptake and Therapeutic Effect of Free and Encapsulated Cabazitaxel 

      Snipstad, Sofie; Mørch, Ýrr; Sulheim, Einar; Åslund, Andreas; Pedersen, André; Hansen, Rune; Davies, Catharina de Lange; Berg, Sigrid (Peer reviewed; Journal article, 2021)
      Delivery of drugs and nanomedicines to tumors is often heterogeneous and insufficient and, thus, of limited efficacy. Microbubbles in combination with ultrasound have been found to improve delivery to tumors, enhancing ...

    • Sonopermeation to improve drug delivery to tumors: from fundamental understanding to clinical translation 

      Snipstad, Sofie; Sulheim, Einar; Davies, Catharina de Lange; Moonen, Chrit; Storm, Gert; Kiessling, Fabian; Schmid, Ruth; Lammers, Twan (Journal article; Peer reviewed, 2018)
      Introduction: Ultrasound in combination with microbubbles can make cells and tissues more accessible for drugs, thereby achieving improved therapeutic outcomes. In this review, we introduce the term ‘sonopermeation’, ...

    • Sonopermeation with nanoparticle-stabilized microbubbles reduces solid stress and improves nanomedicine delivery to tumors 

      Sulheim, Einar; Hanson, Ingunn; Snipstad, Sofie; Vikedal, Krister; Mørch, Ýrr Asbjørg; Boucher, Yves; Davies, Catharina de Lange (Peer reviewed; Journal article, 2021)
      Drug delivery to tumors is challenging due to biological barriers obstructing effective delivery. Sonopermeation with ultrasound and microbubbles has been shown to improve therapeutic effect of many classes of drugs, but ...

    • The Cellular Immune Landscape of Murine Tumor Models Treated with Checkpoint Inhibitor 

      Bremnes, Frida (Master thesis, 2022)
      I denne oppgaven undersøkes effekten av en anti-PD1 sjekkpunktshemmer og implantasjonsstrategi på det cellulære immunlandskapet til murine tumormodeller. Behandling med sjekkpunktshemmere har vist imponerende effekter i ...