Browsing by Author "Sulheim, Einar"
Now showing items 1-13 of 13
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Cabazitaxel-loaded Poly(2-ethylbutyl cyanoacrylate) nanoparticles improve treatment efficacy in a patient derived breast cancer xenograft
Fusser, Markus; Øverbye, Anders; Pandya, Abhilash D.; Mørch, Ýrr Asbjørg; Borgos, Sven Even F.; Kildal, Wanja; Snipstad, Sofie; Sulheim, Einar; Fleten, Karianne Giller; Askautrud, Hanne Arenberg; Engebraaten, Olav; Flatmark, Kjersti; Iversen, Tore Geir; Sandvig, Kirsten; Skotland, Tore; Mælandsmo, Gunhild Mari (Journal article; Peer reviewed, 2018)The effect of poly(2-ethyl-butyl cyanoacrylate) nanoparticles containing the cytotoxic drug cabazitaxel was studied in three breast cancer cell lines and one basal-like patient-derived xenograft model grown in the mammary ... -
Composite PACA Nanoparticle-Alginate Microspheres for Sustained Drug Delivery - Characterization, Optimization, In Vitro Drug Release and Cytotoxicity Studies
Einen, Caroline; Benjakul, Sopisa (Master thesis, 2018) -
Cytotoxicity of poly(Alkyl cyanoacrylate) nanoparticles
Sulheim, Einar; Iversen, Tore Geir; To, Vu; Klinkenberg, Geir; Sletta, Håvard; Schmid, Ruth; Hatletveit, Anne Rein; Wågbø, Ane Marit; Sundan, Anders; Skotland, Tore; Sandvig, Kirsten; Mørch, Ýrr Asbjørg (Journal article; Peer reviewed, 2017)Although nanotoxicology has become a large research field, assessment of cytotoxicity is often reduced to analysis of one cell line only. Cytotoxicity of nanoparticles is complex and should, preferentially, be evaluated ... -
Labeling nanoparticles: Dye leakage and altered cellular uptake
Snipstad, Sofie; Hak, Sjoerd; Baghirov, Habib; Sulheim, Einar; Mørch, Ýrr Asbjørg; Lelu, Sylvie; von Haartman, Eva; Bäck, Marcus; Nilsson, Peter R; Klymchenko, Andrey S; Davies, Ruth Catharina de Lange; Åslund, Andreas (Journal article, 2016)In vitro and in vivo behavior of nanoparticles (NPs) is often studied by tracing the NPs with fluorescent dyes. This requires stable incorporation of dyes within the NPs, as dye leakage may give a wrong interpretation of ... -
Mechanisms of Cellular Uptake and Intracellular Degradation of Polymeric Nanoparticles
Sulheim, Einar (Master thesis, 2014)The effect of cancer therapy could be greatly improved by encapsulating existing drugs into nanoparticles. Nanoparticles can facilitate delivery of hydrophobic drugs with poor solubility in water, and allow you to target ... -
Multi-modal characterization of vasculature and nanoparticle accumulation in five tumor xenograft models
Sulheim, Einar; Kim, Jana; van Wamel, Annemieke; Kim, Eugene; Snipstad, Sofie; Vidic, Igor; Grimstad, Ingeborg; Widerøe, Marius; Torp, Sverre Helge; Lundgren, Steinar; Waxman, David J.; Davies, Catharina de Lange (Journal article; Peer reviewed, 2018)Preclinical research has demonstrated that nanoparticles and macromolecules can accumulate in solid tumors due to the enhanced permeability and retention effect. However, drug loaded nanoparticles often fail to show increased ... -
Nanomedicine and Sonopermeation in the Treatment of Cancer
Sulheim, Einar (Doctoral theses at NTNU;2019:98, Doctoral thesis, 2018)Treatment of cancer is an enormous challenge that involves multiple biological barriers and drugs with limited specificity, which makes treatment both ineffective and debilitating to the patient. One of the approaches that ... -
Nanoparticle-stabilized microbubbles for multimodal imaging and drug delivery
Mørch, Ýrr Asbjørg; Hansen, Rune; Berg, Sigrid; Åslund, Andreas; Glomm, Wilhelm; Eggen, Siv; Schmid, Ruth; Johnsen, Heidi; Kubowicz, Stephan; Snipstad, Sofie; Sulheim, Einar; Hak, Sjoerd; Singh, Gurvinder; McDonagh, Birgitte Hjelmeland; Blom, Hans; Davies, Ruth Catharina de Lange; Stenstad, Per Martin (Journal article, 2015)Microbubbles (MBs) are routinely used as contrast agents for ultrasound imaging. The use of ultrasound in combination with MBs has also attracted attention as a method to enhance drug delivery. We have developed a technology ... -
Quantification and Qualitative Effects of Different PEGylations on Poly(butyl cyanoacrylate) Nanoparticles
Åslund, Andreas; Sulheim, Einar; Snipstad, Sofie; von Haartman, Eva; Baghirov, Habib; Starr, Nichola; Løvmo, Mia Kvåle; Lelu, Sylvie; Scurr, David; Davies, Catharina De Lange; Schmid, Ruth; Mørch, Yrr Asbjørg (Journal article, 2017)Protein adsorption on nanoparticles (NPs) used in nanomedicine leads to opsonization and activation of the complement system in blood, which substantially reduces the blood circulation time of NPs. The most commonly used ... -
Sonopermeation to improve drug delivery to tumors: from fundamental understanding to clinical translation
Snipstad, Sofie; Sulheim, Einar; Davies, Catharina de Lange; Moonen, Chrit; Storm, Gert; Kiessling, Fabian; Schmid, Ruth; Lammers, Twan (Journal article; Peer reviewed, 2018)Introduction: Ultrasound in combination with microbubbles can make cells and tissues more accessible for drugs, thereby achieving improved therapeutic outcomes. In this review, we introduce the term ‘sonopermeation’, ... -
The effect of poly(ethylene glycol) coating and monomer type on poly(alkyl cyanoacrylate) nanoparticle interactions with lipid monolayers and cells
Baghirov, Habib; Melikishvili, Sopio; Mørch, Yrr Asbjørg; Sulheim, Einar; Åslund, Andreas; Hianik, Tibor; Davies, Ruth Catharina de Lange (Journal article, 2017)The interaction of the promising drug carriers poly(alkyl cyanoacrylate) nanoparticles (PACA NPs) with lipid monolayers modeling the cell membrane and with RBE4 immortalized rat brain endothelial cells was compared to ... -
Ultrasound Improves the Delivery and Therapeutic Effect of Nanoparticle-Stabilized Microbubbles in Breast Cancer Xenografts
Snipstad, Sofie; Berg, Sigrid; Mørch, Ýrr Asbjørg; Bjørkøy, Astrid; Sulheim, Einar; Hansen, Rune; Grimstad, Ingeborg; van Wamel, Annemieke; Maaland, Astri Fjelde; Torp, Sverre Helge; Davies, Ruth Catharina de Lange (Journal article; Peer reviewed, 2017)Compared with conventional chemotherapy, encapsulation of drugs in nanoparticles can improve efficacy and reduce toxicity. However, delivery of nanoparticles is often insufficient and heterogeneous because of various ... -
Ultrasound-mediated delivery and distribution of polymeric nanoparticles in the normal brain parenchyma of a metastatic brain tumour model
Baghirov, Habib; Snipstad, Sofie; Sulheim, Einar; Berg, Sigrid; Hansen, Rune; Thorsen, Frits; Mørch, Ýrr Asbjørg; Davies, Catharina de Lange; Åslund, Andreas (Journal article; Peer reviewed, 2018)The treatment of brain diseases is hindered by the blood-brain barrier (BBB) preventing most drugs from entering the brain. Focused ultrasound (FUS) with microbubbles can open the BBB safely and reversibly. Systemic drug ...