Browsing NTNU Open by Author "Strand, Berit Løkensgard"
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A correlative spatiotemporal microscale study of calcium phosphate formation and transformation within an alginate hydrogel matrix.
Bassett, David; Ucar, Seniz; Sikorski, Pawel; Andreassen, Jens-Petter; Bjørnøy, Sindre Hove; Strand, Berit Løkensgard (Journal article; Peer reviewed, 2016)The modification of soft hydrogels with hard inorganic components is a method used to form composite materials with application in non-load-bearing bone tissue engineering. The inclusion of an inorganic component may provide ... -
Alginate Beads for the Treatment of Diabetes - Development of Larger Beads with Various Compartments
Kjesbu, Joachim Sebastian (Master thesis, 2016)Some diseases lead to the loss of specific types of cells and their associated products, notably type 1 diabetes, an autoimmune disease which causes the loss of the insulin producing β-cells native to the pancreas. Cell ... -
Alginate microbeads are complement compatible, in contrast to polycation containing microcapsules, as revealed in a human whole blood model
Rokstad, Anne Mari; Brekke, Ole Lars; Steinkjer, Bjørg; Ryan, Liv; Kolláriková, Gabriela; Strand, Berit Løkensgard; Skjåk-Bræk, Gudmund; Lacík, Igor; Espevik, Terje; Mollnes, Tom Eirik (Journal article; Peer reviewed, 2011)Alginate microbeads and microcapsules are presently under evaluation for future cell-based therapy. Defining their inflammatory properties with regard to humans is therefore essential. A lepirudine-based human whole blood ... -
Alginate Microencapsulation of Human Islets Does Not Increase Susceptibility to Acute Hypoxia
Hals, Ingrid Katrin; Rokstad, Anne Mari; Strand, Berit Løkensgard; Oberholzer, José; Grill, Valdemar (Journal article; Peer reviewed, 2013)Islet transplantation in diabetes is hampered by the need of life-long immunosuppression. Encapsulation provides partial immunoprotection but could possibly limit oxygen supply, a factor that may enhance hypoxia-induced ... -
Alginate-polycation capsules as microcarriers for cell culture - Preparation and characterization
Solheim, Ingeborg Elisabeth (Master thesis, 2019)Celler kan miste sin form og funksjon når de blir kultivert på 2D-overflater, som er den nåværende standarden. Derfor kreves bedre kultiveringsmetoder for å få et mer nøyaktig bilde av cellenes oppførsel og interaksjoner. ... -
Analysis of G-Block Distributions and Their Impact on Gel Properties of in Vitro Epimerized Mannuronan
Aarstad, Olav Andreas; Strand, Berit Løkensgard; Klepp-Andersen, Lise Mari; Skjåk-Bræk, Gudmund (Journal article; Peer reviewed, 2013)This paper reports a study of the distribution and function of homopolymeric guluronic acid blocks (G-blocks) in enzymatically modified alginate. High molecular weight mannuronan was incubated with one native (AlgE6) and ... -
Assay development for live IL-1B detection from individual THP-1 cells
de Bakker, Steven (Master thesis, 2018)Protein secretion is an important process that allows for cell-cell communication and coordinated immune responses to be carried out by immune cells. Methods for the study of cytokine secretion of large cell populations ... -
Biocompatibility and Biotolerability Assessment of Microspheres Using a Whole Blood Model
Rokstad, Anne Mari; Strand, Berit Løkensgard; Espevik, Terje; Mollnes, Tom Eirik (Journal article, 2013)The whole blood model is a powerful method to determine the immediate inflammatory reactions towards foreign objects in general. This review focuses on the use of a lepirudin based whole blood model for evaluating microspheres ... -
Biocomposites prepared by alkaline phosphatase mediated mineralization of alginate microbeads
Xie, Minli; Magnus Østgård, Olderøy; Zhang, Zhibing; Andreassen, Jens-Petter; Strand, Berit Løkensgard; Sikorski, Pawel (Journal article; Peer reviewed, 2012)This study set out to develop a biomimetic scaffold by incorporating osteoinductive hydroxyapatite (HA) particles into a porous alginate gel matrix via a cell-friendly pathway. Two types of alginate/calcium phosphate ... -
Centre for Digital Life Norway - Annual report 2017
Johansen, Finn-Eirik; Brautaset, Trygve; Aune, Marie Hjelmseth; Patriksson, Alexandra; Falkenberg, Liv Eggset; Kleppe, Rune; Dick, Gunnar; Strand, Berit Løkensgard; Eijsink, Vincent; Røyne, Anja; Goksøyr, Anders; Svendsen, John Sigurd Mjøen; Fyhn, Marianne; Vik, Jon Olav; Wentzel, Alexander; Aksnes, Astrid; Bruheim, Per; Carlsen, Sven Magnus; Åm, Heidrun (Research report, 2018) -
Chemically modified alginates and chitosans Lateral and terminal functionalization by reductive amination
Dalheim, Marianne Øksnes (Doctoral theses at NTNU;2016:274, Doctoral thesis, 2016)ENGLISH: Polysaccharides with added functions and/or modified properties are of increasing interest in preparing new materials suitable for both industrial applications and more advanced applications within biomedical ... -
Coating of alginate capsules
Hadjialirezaei, Soosan (Master thesis, 2013)Alginate is a popular candidate for encapsulation of cells due to the formation of gels with divalent ions under physiological conditions. Stable alginate gels can be formed by the selection of alginates with a high content ... -
Composite Hydrogels of Alginate and Cellulose Nanofibrils - A study of mechanical properties
Pedersen, Ina Sander (Master thesis, 2018)The main focus of this thesis was to attain more information about how alginate - CNF composite hydrogels are affected by each of the two polysaccharides, in order to gain additional knowledge which could be used to ... -
Composite PACA Nanoparticle-Alginate Microspheres for Sustained Drug Delivery - Characterization, Optimization, In Vitro Drug Release and Cytotoxicity Studies
Einen, Caroline; Benjakul, Sopisa (Master thesis, 2018) -
Culture of hESC-derived pancreatic progenitors in alginate-based scaffold
Formo, Kjetil Ødegård; Cho, Candy H-H; Vallier, Ludovic; Strand, Berit Løkensgard (Journal article; Peer reviewed, 2015)The effect of alginate-based scaffolds with added basement membrane proteins on the in vitro development of hESC-derived pancreatic progenitors was investigated. Cell clusters were encapsulated in scaffolds containing the ... -
Current and Future Perspectives on Alginate Encapsulated Pancreatic Islet
Strand, Berit Løkensgard; Coron, Abba Elizabeth; Skjåk-Bræk, Gudmund (Journal article; Peer reviewed, 2017)Transplantation of pancreatic islets in immune protective capsules holds the promise as a functional cure for type 1 diabetes, also about 40 years after the first proof of principal study. The concept is simple in using ... -
Degradation of Calcium Gels of Alginate and Periodate Oxidised Alginate
Marinho Carvalho Bjørge, Isabel (Master thesis, 2016)The extracellular matrix (ECM) functions as a structural scaffold for cells and controls cellular function through cell-matrix interactions. These interactions are required by most cells in order to maintain viable and ... -
Efficient functionalization of alginate biomaterials
Dalheim, Marianne Øksnes; Vanacker, Julie; Najmi, Maryam A.; Aachmann, Finn Lillelund; Strand, Berit Løkensgard; Christensen, Bjørn E. (Journal article; Peer reviewed, 2016)Peptide coupled alginates obtained by chemical functionalization of alginates are commonly used as scaffold materials for cells in regenerative medicine and tissue engineering. We here present an alternative to the commonly ... -
Efficient Grafting of Cyclodextrin to Alginate and Performance of the Hydrogel for Release of Model Drug
Omtvedt, Line Aanerud; Dalheim, Marianne Øksnes; Nielsen, Thorbjørn T.; Larsen, Kim; Strand, Berit Løkensgard; Aachmann, Finn Lillelund (Journal article; Peer reviewed, 2019)Controlling the rate of release of molecules from a hydrogel is of high interest for various drug delivery systems and medical devices. A strategy to alter the release profiles of soluble and poorly soluble active ingredients ... -
Formation of Hydroxyapatite via Transformation of Amorphous Calcium Phosphate in the Presence of Alginate Additives
Ucar, Seniz; Bjørnøy, Sindre Hove; Bassett, David; Strand, Berit Løkensgard; Sikorski, Pawel; Andreassen, Jens-Petter (Journal article; Peer reviewed, 2019)Hydroxyapatite (HA) is the primary mineral of vertebral tooth and bone tissue; thus, it is often incorporated into synthetic composite materials designed for hard tissue engineering applications. Understanding the formation ...