Browsing NTNU Open by Author "Starheim, Kristian K."
Now showing items 1-6 of 6
-
Characterization of birinapant-induced cell death in human monocytes and macrophage subtypes
Klaharn, Merisa (Master thesis, 2019)Macrophages play various roles in the body depending on the environment they reside due to their diversity and plasticity. Distinct functional phenotypes operate specific tasks, ranging from inflammation and host defense ... -
Depletion of the human N-terminal acetyltransferase hNaa30 disrupts Golgi integrity and ARFRP1 localization
Starheim, Kristian K.; Kalvik, Thomas Vikestad; Bjørkøy, Geir; Arnesen, Thomas (Journal article; Peer reviewed, 2017)The organization of the Golgi apparatus (GA) is tightly regulated. Golgi stack scattering is observed in cellular processes such as apoptosis and mitosis, and has also been associated with disruption of cellular lipid ... -
Pharmaceutical targeting of RIPK1-signaling: Characterization of cell death in human macrophage systems and therapeutic potential in multiple myeloma
Moen, Ingrid Nyhus (Doktoravhandlingar ved NTNU;2021:411, Doctoral thesis, 2021)The receptor-interacting protein kinase 1 (RIPK1)-pathway is a key regulator of inflammation and cell death. RIPK1-dependent cell death has been well studied in murine macrophages but as it is context dependent and differently ... -
Smac-mimetics reduce numbers and viability of human osteoclasts
Moen, Ingrid Nyhus; Westhrin, Marita; Håland, Erling; Haug, Markus; Nonstad, Unni; Klaharn, Merisa; Standal, Therese; Starheim, Kristian K. (Peer reviewed; Journal article, 2021)Elevated activity of bone-degrading osteoclasts (OC) contributes to pathological bone degradation in diseases such as multiple myeloma. Several proinflammatory cytokines, including TNF, contribute to osteoclastogenesis. ... -
The TLR4 adaptor TRAM controls the phagocytosis of Gram-negative bacteria by interacting with the Rab11-family interacting protein 2
Skjesol, Astrid; Yurchenko, Mariya; Bösl, Korbinian; Gravastrand, Caroline S.; Nilsen, Kaja Elisabeth; Grøvdal, Lene Melsæther; Agliano, Federica; Patane, Francesco; Lentini, Germana; Kim, Hera; Teti, Giuseppe; Sharma, Aditya Kumar; Kandasamy, Richard Kumaran; Sporsheim, Bjørnar; Starheim, Kristian K.; Golenbock, Douglas T.; Stenmark, Harald; McCaffrey, Mary; Espevik, Terje; Husebye, Harald (Journal article; Peer reviewed, 2019)Phagocytosis is a complex process that eliminates microbes and is performed by specialised cells such as macrophages. Toll-like receptor 4 (TLR4) is expressed on the surface of macrophages and recognizes Gram-negative ... -
The TLR4 adaptor TRAM controls the phagocytosis of Gram-negative bacteria by interacting with the Rab11-family interacting protein 2
Skjesol, Astrid; Yurchenko, Mariya; Bösl, Korbinian; Gravastrand, Caroline S.; Nilsen, Kaja Elisabeth; Grøvdal, Lene Melsæther; Agliano, Federica; Patane, Francesco; Lentini, Germana; Kim, Hera; Teti, Giuseppe; Sharma, Aditya Kumar; Kandasamy, Richard Kumaran; Sporsheim, Bjørnar; Starheim, Kristian K.; Golenbock, Douglas T.; Stenmark, Harald; McCaffrey, Mary; Espevik, Terje; Husebye, Harald (Peer reviewed; Journal article, 2019)Phagocytosis is a complex process that eliminates microbes and is performed by specialised cells such as macrophages. Toll-like receptor 4 (TLR4) is expressed on the surface of macrophages and recognizes Gram-negative ...