• Alternative anesthesia of neonatal mice for global rAAV delivery in the brain with non-detectable behavioral interference in adults 

      Tang, Wannan; Zillmann, Uwe; Sprengel, Rolf (Peer reviewed; Journal article, 2020)
      Viral-transduced gene expression is the current standard for cell-type-specific labeling and cell tacking in experimental neuroscience. To achieve widespread gene expression, a viral delivery method to neonatal rodents was ...
    • Astrocytic Ca2+ signaling is reduced during sleep and is involved in the regulation of slow wave sleep 

      Bojarskaite, Laura; Bjørnstad, Daniel Marelius; Pettersen, Klas; Cunen, Celine; Hermansen, Gudmund Horn; Åbjørsbråten, Knut Sindre; Chambers, Anna; Sprengel, Rolf; Vervaeke, Koen Gerard Alois; Tang, Wannan; Enger, Rune; Nagelhus, Erlend Arnulf (Peer reviewed; Journal article, 2020)
      Astrocytic Ca2+ signaling has been intensively studied in health and disease but has not been quantified during natural sleep. Here, we employ an activity-based algorithm to assess astrocytic Ca2+ signals in the neocortex ...
    • Voltage-independent GluN2A-type NMDA receptor Ca2+ signaling promotes audiogenic seizures, attentional and cognitive deficits in mice 

      Bertocchi, Ilaria; Eltokhi, Ahmed; Rozov, Andrey; Nguyễn Chi, Vivan; Jensen, Vidar; Bus, Thorsten; Pawlak, Verena; Serafino, Marta; Sonntag, Hannah; Yang, Boyi; Burnashev, Nail; Li, Shi-Bin; Obenhaus, Horst-Andreas; Both, Martin; Niewoehner, Burkhard; Single, Frank N.; Briese, Michael; Boerner, Thomas; Gass, Peter; Rawlins, John Nick P.; Köhr, Georg; Bannerman, David M.; Sprengel, Rolf (Peer reviewed; Journal article, 2021)
      The NMDA receptor-mediated Ca2+ signaling during simultaneous pre- and postsynaptic activity is critically involved in synaptic plasticity and thus has a key role in the nervous system. In GRIN2-variant patients alterations ...