Browsing NTNU Open by Author "Sonnewald, Ursula"
Now showing items 1-13 of 13
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A comprehensive metabolic profile of cultured astrocytes using isotopic transient metabolic flux analysis and 13C-labeled glucose
Amaral, Ana; Teixeira, Ana P; Håkonsen, Bjørn Isak; Sonnewald, Ursula; Alves, Paula (Journal article; Peer reviewed, 2011)Metabolic models have been used to elucidate important aspects of brain metabolism in recent years. This work applies for the first time the concept of isotopic transient 13C metabolic flux analysis (MFA) to estimate ... -
Changes in synaptic proteins in hippocampal area CA1 of a rat learned helpless model of depression
Bieler, Malte (Master thesis, 2013)Major depressive disorder (MDD) is one of the most common mood disorders in the world with a life-time prevalence of approximately 17%. MDD is characterized by emotional and cognitive disturbances, and is accompanied by ... -
Entorhinal cell-specific changes as an initial cause of Alzheimer's disease
Kobro-Flatmoen, Asgeir (Doctoral theses at NTNU;2017:74, Doctoral thesis, 2017)Evidence shows that Alzheimer’s disease (AD) begins with subtle and anatomically restricted pathological changes within the brain, ultimately leading to widespread neuronal loss and dementia. While high numbers of ... -
Functional metabolic interactions of human neuron-astrocyte 3D in vitro networks
Simao, Daniel; Terrasso, Ana P; Teixeira, Ana P; Brito, Catarina; Sonnewald, Ursula; Alves, Paula M. (Peer reviewed; Journal article, 2016)The generation of human neural tissue-like 3D structures holds great promise for disease modeling, drug discovery and regenerative medicine strategies. Promoting the establishment of complex cell-cell interactions, 3D ... -
Glutamate related metabolism in animal models of schizophrenia
Brenner, Eiliv (Doktoravhandlinger ved NTNU, 1503-8181; 2011:78, Doctoral thesis, 2011)Schizophrenia is a clinical syndrome of variable psychopathology, which involves thought, perception, emotion, movement and behavior. The cumulative effect of the illness is always severe and usually long lasting. Epidemiologic ... -
Improvement of neuronal differentiation by carbon monoxide: Role of pentose phosphate pathway
Almeida, Ana S; Soares, Nuno L; Sequeira, Catarina O; Pereira, Sofia A; Sonnewald, Ursula; Vieira, Helena LA (Journal article; Peer reviewed, 2018)Over the last decades, the silent-killer carbon monoxide (CO) has been shown to also be an endogenous cytoprotective molecule able to inhibit cell death and modulate mitochondrial metabolism. Neuronal metabolism is mostly ... -
Loss or mislocalization of aquaporin-4 affects diffusion properties and intermediary metabolism in gray matter of mice
Pavlin, Tina; Nagelhus, Erlend Arnulf; Brekken, Christian; Eyjolfsson, Elvar M.; Thoren, Anna; Haraldseth, Olav; Sonnewald, Ursula; Ottersen, Ole Petter; Håberg, Asta (Journal article; Peer reviewed, 2017)The first aim of this study was to determine how complete or perivascular loss of aquaporin-4 (AQP4) water channels affects membrane permeability for water in the mouse brain grey matter in the steady state. Time-dependent ... -
Melatonin treatment after neonatal hypoxic-ischemic brain injury: a multimodal MR study
Berger, Hester Rijkje (Doctoral theses at NTNU;2018:63, Doctoral thesis, 2018) -
Neuron-astrocyte interactions, pyruvate carboxylation and the pentose phosphate pathway in the neonatal rat brain
Morken, Tora Sund; Brekke, Eva Mari Førland; Håberg, Asta; Widerøe, Marius; Brubakk, Ann-Mari; Sonnewald, Ursula (Journal article; Peer reviewed, 2014)Glucose and acetate metabolism and the synthesis of amino acid neurotransmitters, anaplerosis, glutamate-glutamine cycling and the pentose phosphate pathway (PPP) have been extensively investigated in the adult, but not ... -
Regulatory Role of Synaptic Proteins in Chronic Medial Temporal Lobe Epilepsy
Egbenya, Daniel Lawer (Master thesis, 2013)Knowledge of the regulatory function of synaptic proteins in neurodegenerative diseases can be useful in developing neuroprotective measures against these diseases. Therefore, the regulatory role of some synaptic proteins, ... -
The effects of carisbamate on [1- 13C]glucose and [1,2- 13C]acetate metabolism in the limbic structures of the lithium-pilocarpine model of temporal lobe epilepsy in rats
Tefera, Tesfaye Wolde (Master thesis, 2013)TLE is a type of focal epilepsy which is often resistant to medication. There is a need for the development of new drugs to treat patients and, even more important, to prevent epileptogenesis. Carisbamate (CRS) showed ... -
The effects of carisbamate on the thalamic metabolism of [1-13C]glucose and [1,2-13C]acetate in the lithium-pilocarpine rat model
Berggaard, Nina (Master thesis, 2013)Temporal lobe epilepsy is the most common type of epilepsy, the latter which has a worldwide occurrence of approximately 1%. As it is also a highly intractable disease, there is a pressing need for the development or ... -
Tissue characterization by high resolution magic angle spinning MR spectroscopy
Sitter, Beathe (Doktoravhandlinger ved NTNU, 1503-8181; 2004:41, Doctoral thesis, 2004)Vevs-karakterisering med høyoppløsning MAS MR spektroskopi Høyoppløsning MAS er en MR spektroskopisk metode som gir høyt oppløste spekter av faste materialer. I dette doktorgradsarbeidet har høyoppløsning MAS blitt anvendt ...