Browsing NTNU Open by Author "Sommer, Christine"

Now showing items 1-6 of 6

    • Cohort profile: Epigenetics in Pregnancy (EPIPREG) – Population-based sample of European and South Asian pregnant women with epigenome-wide DNA methylation (850k) in peripheral blood leukocytes 

      Fragoso-Bargas, Nicolas; Opsahl, Julia Onsrud; Kiryushchenko, Nadezhda; Böttcher, Yvonne; Lee-Ødegård, Sindre; Qvigstad, Elisabeth; Richardsen, Kåre Rønn; Waage, Christin; Sletner, Line; Jenum, Anne Karen; Prasad, Rashmi B.; Groop, Leif C.; Moen, Gunn-Helen Øiseth; Birkeland, Kåre Inge; Sommer, Christine (Journal article; Peer reviewed, 2021)
      Pregnancy is a valuable model to study the association between DNA methylation and several cardiometabolic traits, due to its direct potential to influence mother’s and child’s health. Epigenetics in Pregnancy (EPIPREG) ...

    • Comparison of the associations between non-traditional and traditional indices of adiposity and cardiovascular mortality: an observational study of one million person-years of follow-up 

      Ofstad, Anne Pernille; Sommer, Christine; Birkeland, Kåre I.; Bjørgaas, Marit Ragnhild Rokne; Gran, Jon Michael; Gulseth, Hanne Løvdal; Johansen, Odd Erik (Journal article; Peer reviewed, 2019)
      Background/objective The most widely used adiposity index, body mass index (BMI), is not optimal to evaluate cardiovascular (CV) risk associated with overweight and obesity. We aimed to explore the association between ...

    • Epigenome-wide association study of serum folate in maternal peripheral blood leukocytes 

      Fragoso-Bargas, Nicolas; Page, Christian Magnus; Joubert, Bonnie R.; London, Stephanie J.; Lee-Ødegård, Sindre; Opsahl, Julia Onsrud; Sletner, Line; Jenum, Anne Karen; Qvigstad, Elisabeth; Prasad, Rashmi B.; Moen, Gunn-Helen Øiseth; Birkeland, Kåre Inge; Sommer, Christine (Peer reviewed; Journal article, 2023)
      Aim: To perform an epigenome-wide association study (EWAS) of serum folate in maternal blood. Methods: Cross-ancestry (Europeans = 302, South Asians = 161) and ancestry-specific EWAS in the EPIPREG cohort were performed, ...

    • Insulin and Body Mass Index Decrease Serum Soluble Leptin Receptor Levels in Humans 

      Sommer, Christine; Vangberg, Kjersti G.; Moen, Gunn-Helen Øiseth; Evans, David M.; Lee-Ødegård, Sindre; Høgestøl, Ingvild Kristine; Sletner, Line; Jenum, Anne Karen; Drevon, Christian A.; Gulseth, Hanne Løvdal; Birkeland, Kåre Inge (Peer reviewed; Journal article, 2022)
      Context Serum soluble leptin receptor (sOb-R) may protect against future type 2 diabetes or serve as a marker for protective features, but how sOb-R is regulated is largely unknown. Objective This work aimed to test ...

    • Investigating the causal effect of maternal vitamin B12 and folate levels on offspring birthweight 

      Moen, Gunn-Helen; Beaumont, Robin N.; Grarup, Niels; Sommer, Christine; Shields, Beverley M.; Lawlor, Debbie A.; Freathy, Rachel M.; Evans, David M.; Warrington, Nicole Maree (Peer reviewed; Journal article, 2021)
      Background Lower maternal serum vitamin B12 (B12) and folate levels have been associated with lower offspring birthweight, in observational studies. The aim of this study was to investigate whether this relationship is ...

    • Multi-ancestry genome-wide association study of gestational diabetes mellitus highlights genetic links with type 2 diabetes 

      Pervjakova, Natalia; Moen, Gunn-Helen Øiseth; Borges, Maria-Carolina; Ferreira, Teresa; Cook, James P.; Allard, Catherine; Beaumont, Robin N.; Canouil, Mickaël; Hatem, Gad; Heiskala, Anni; Joensuu, Anni; Karhunen, Ville; Kwak, Soo Heon; Lin, Frederick T J; Liu, Jun; Rifas-Shiman, Sheryl; Tam, Claudia H.; Tam, Wing Hung; Thorleifsson, Gudmar; Andrew, Toby; Auvinen, Juha; Bhowmik, Bishwajit; Bonnefond, Amélie; Delahaye, Fabien; Demirkan, Ayse; Froguel, Philippe; Haller-Kikkatalo, Kadri; Hardardottir, Hildur; Hummel, Sandra; Hussain, Akhtar; Kajantie, Eero Olavi; Keikkala, Elina; Khamis, Amna; Lahti, Jari; Lekva, Tove; Mustaniemi, Sanna; Sommer, Christine; Tagoma, Aili; Tzala, Evangelia; Uibo, Raivo; Vääräsmäki, Marja; Villa, Pia M.; Birkeland, Kåre Inge; Bouchard, Luigi; Duijn, Cornelia M.; Finer, Sarah; Groop, Leif; Hämäläinen, Esa; Hayes, Geoffrey M.; Hitman, Graham A.; Jang, Hak C.; Järvelin, Marjo-Riitta; Jenum, Anne Karen; Laivuori, Hannele; Ma, Ronald C.; Melander, Olle; Oken, Emily; Park, Kyong Soo; Perron, Patrice; Prasad, Rashmi B.; Qvigstad, Elisabeth; Sebert, Sylvain; Stefansson, Kari; Steinthorsdottir, Valgerdur; Tuomi, Tiinamaija; Hivert, Marie-France; Franks, Paul W.; McCarthy, Mark I.; Lindgren, Cecilia M.; Freathy, Rachel M.; Lawlor, Deborah A.; Morris, Andrew P.; Mägi, Reedik (Peer reviewed; Journal article, 2022)
      Gestational diabetes mellitus (GDM) is associated with increased risk of pregnancy complications and adverse perinatal outcomes. GDM often reoccurs and is associated with increased risk of subsequent diagnosis of type 2 ...