Browsing NTNU Open by Author "Simpson, Melanie Rae"
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Atopic dermatitis prevention in children following maternal probiotic supplementation does not appear to be mediated by breast milk TSLP or TGF-β.
Simpson, Melanie Rae; Rø, Anne Dorthea; Grimstad, Øystein; Johnsen, Roar; Storrø, Ola; Øien, Torbjørn (Journal article; Peer reviewed, 2016)Background: The Probiotics in Prevention of Allergy among Children in Trondheim (ProPACT) study, a randomised, placebo controlled trial, demonstrated that maternal supplementation with probiotic milk reduced the incidence ... -
Breastfeeding associated microbiota in human milk following supplementation with Lactobacillus rhamnosus GG, Lactobacillus acidophilus La-5 and Bifidobacterium animalis subspecies lactis Bb-12
Simpson, Melanie Rae; Avershina, Ekaterina; Storrø, Ola; Johnsen, Roar; Rudi, Knut; Øien, Torbjørn (Journal article; Peer reviewed, 2017)Breastfeeding is one of the major factors affecting the early development of the infant gut microbiota, and weaning is associated with a shift in the gut microbiota toward a more adult composition. Through breastfeeding, ... -
Diversity of vaginal microbiota increases by the time of labor onset
Avershina, Ekaterina; Slangsvold, Silje; Simpson, Melanie Rae; Storrø, Ola; Johnsen, Roar; Øien, Torbjørn; Rudi, Knut (Journal article; Peer reviewed, 2017)Vaginal microbiota is an important early source of bacterial colonization for newborns. However, only a few small studies have investigated the composition of vaginal microbiota during labor. In this work, we analyzed ... -
Duration of breastfeeding, age at introduction of complementary foods and allergy-related diseases: a prospective cohort study
Ekelund, Louise; Gloppen, Inga; Øien, Torbjørn; Simpson, Melanie Rae (Peer reviewed; Journal article, 2021)Background The influences of breastfeeding and infant diet in the prevention of allergy-related diseases are uncertain and many of the studies conducted on the topic are limited by methodological challenges. Our aim was ... -
Early gut fungal and bacterial microbiota and childhood growth
Schei, Kasper; Simpson, Melanie Rae; Avershina, Ekaterina; Rudi, Knut; Øien, Torbjørn; Juliusson, Petur Benedikt; Underhill, David; Salamati, Saideh; Ødegård, Rønnaug (Peer reviewed; Journal article, 2020)Introduction: Childhood growth is a sensitive marker of health. Animal studies show increased height and weight velocity in the presence of fungal as well as antibiotic supplement in feed. Human studies on early gut ... -
Fish Consumption at One Year of Age Reduces the Risk of Eczema, Asthma and Wheeze at Six Years of Age
Øien, Torbjørn; Schjelvaag, Astrid; Storrø, Ola; Johnsen, Roar; Simpson, Melanie Rae (Journal article; Peer reviewed, 2019)We present a novel liquid array diagnostics (LAD) method, which enables rapid and inexpensive detection of microbial markers in a single-tube multiplex reaction. We evaluated LAD both on pure cultures, and on infant gut ... -
Human Breast Milk miRNA, Maternal Probiotic Supplementation and Atopic Dermatitis in Offspring
Simpson, Melanie Rae; Brede, Gaute; Johansen, Jostein; Johnsen, Roar; Storrø, Ola; Sætrom, Pål; Øien, Torbjørn (Peer reviewed; Journal article, 2015)Background: Perinatal probiotic ingestion has been shown to prevent atopic dermatitis (AD) in infancy in a number of randomised trials. The Probiotics in the Prevention of Allergy among Children in Trondheim (ProPACT) trial ... -
Low maternal microbiota sharing across gut, breast milk and vagina, as revealed by 16s rRNA gene and reduced metagenomic sequencing
Avershina, Ekaterina; Angell, Inga Leena; Simpson, Melanie Rae; Storrø, Ola; Øien, Torbjørn; Johnsen, Roar; Rudi, Knut (Journal article; Peer reviewed, 2018)The maternal microbiota plays an important role in infant gut colonization. In this work we have investigated which bacterial species are shared across the breast milk, vaginal and stool microbiotas of 109 women shortly ... -
Perinatal probiotic supplementation in the prevention of allergy related disease: 6 year follow up of a randomised controlled trial
Simpson, Melanie Rae; Dotterud, Christian Kvikne; Storrø, Ola; Johnsen, Roar; Øien, Torbjørn (Journal article; Peer reviewed, 2015)Background: Perinatal probiotics supplementation has been shown to be effective in the primary prevention of atopic dermatitis (AD) in early childhood, although the long term effects of probiotics on AD and other allergic ... -
Preventing atopic dermatitis with probiotic supplementation - the role of selected breast milk components: The Probiotics in the Prevention of Allergy among Children in Trondheim (ProPACT) study
Simpson, Melanie Rae (Doctoral theses at NTNU;2018:116, Doctoral thesis, 2018)Probiotika i forebygging av atopisk eksem - rollen til utvalgte morsmelk faktorer Probiotikatilskudd i siste del av svangerskapet og de første levemåneder forebygger utvikling av atopisk dermatitt hos barn. Denne effekten ... -
Reduced Th22 cell proportion and prevention of atopic dermatitis in infants following maternal probiotic supplementation
Rø, Anne Dorthea; Simpson, Melanie Rae; Rø, Torstein Baade; Storrø, Ola; Johnsen, Roar; Videm, Vibeke; Øien, Torbjørn (Journal article; Peer reviewed, 2017)Background In the randomized, controlled study Probiotics in the Prevention of Allergy among Children in Trondheim (ProPACT), maternal probiotic supplementation reduced the incidence of atopic dermatitis (AD) in the ... -
Statistical approaches in the studies assessing associations between human milk immune composition and allergic diseases: A scoping review
Blyuss, Oleg; Cheung, Ka Yan; Chen, Jessica; Parr, Callum; Petrou, Loukia; Komarova, Alina; Kokina, Maria; Luzan, Polina; Pasko, Egor; Eremeeva, Alina; Peshko, Dmitrii; Eliseev, Vladimir I; Pedersen, Sindre Andre; Azad, Meghan B; Jarvinen, Kirsi M; Peroni, Diego G; Verhasselt, Valerie; Boyle, Robert J; Warner, John O; Simpson, Melanie Rae; Munblit, Daniel (Journal article; Peer reviewed, 2019)A growing number of studies are focusing on the associations between human milk (HM) immunological composition and allergic diseases. This scoping review aims to identify statistical methods applied in the field and highlight ... -
The impact of pre- and postnatal exposures on allergy related diseases in childhood: a controlled multicentre intervention study in primary health care
Dotterud, Christian Kvikne; Storrø, Ola; Simpson, Melanie Rae; Johnsen, Roar; Øien, Torbjørn (Journal article; Peer reviewed, 2013)Background: Environmental factors such as tobacco exposure, indoor climate and diet are known to be involved in the development of allergy related diseases. The aim was to determine the impact of altered exposure to ...