Browsing NTNU Open by Author "Simpson, Melanie Rae"
Now showing items 1-20 of 49
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Addressing Domestic Violence in Antenatal Care Environments in Nepal (ADVANCE) – study protocol for a randomized controlled trial evaluating a video intervention on domestic violence among pregnant women
Chalise, Pratibha; Manandhar, Pratibha; Infanti, Jennifer Jean; Campbell, Jacquelyn C; Henriksen, Lena; Joshi, Sunil Kumar; Koju, Rajendra; Pun, Kunta Devi; Rishal, Poonam; Simpson, Melanie Rae; Skovlund, Eva; Swahnberg, Katarina; Schei, Berit; Lukasse, Mirjam (Peer reviewed; Journal article, 2023)Background Domestic violence (DV) prior to, and during pregnancy is associated with increased risks for morbidity and mortality. As pregnant women routinely attend antenatal care this environment can be used to offer ... -
Allergy-related diseases and early gut fungal and bacterial microbiota abundances in children
Schei, Kasper; Simpson, Melanie Rae; Øien, Torbjørn; Salamati, Saideh; Rudi, Knut; Ødegård, Rønnaug (Journal article; Peer reviewed, 2021)Background The early gut microbiota has been proposed as an important link between environmental exposures and development of allergy-related diseases. Beyond the widely investigated associations between the gut bacterial ... -
Anthropometrics of neonates born to mothers with PCOS compared to a reference population, - pooled data from three RCTs and The Norwegian Mother, Father and Child Cohort Study (MoBa)
Talmo, Maren Sophie Aaserud; Fløysand, Ingvild Skogedal (Master thesis, 2023)Hensikt: Formålet med oppgaven er å undersøke effekten av polycystisk ovariesyndrom (PCOS) på nyfødtsantropometri og om eventuell effekt påvirkes av mors kroppsmasseindeks (KMI), PCOS fenotype og om hun har svangerskapsdiabetes ... -
Anthropometrics of neonates born to mothers with PCOS compared to a reference population, - pooled data from three RCTs and The Norwegian Mother, Father and Child Cohort Study (MoBa).
Fløysand, Ingvild Skogedal; Talmo, Maren Sophie Aaserud (Master thesis, 2023)Hensikt: Formålet med oppgaven er å undersøke effekten av polycystisk ovariesyndrom (PCOS) på nyfødtsantropometri og om eventuell effekt påvirkes av mors kroppsmasseindeks (KMI), PCOS fenotype og om hun har svangerskapsdiabetes ... -
Anthropometrics of neonates born to mothers with PCOS with metformin or placebo exposure in utero
Nilsen, Guro Ørndal; Simpson, Melanie Rae; Hanem, Liv Guro Engen; Løvvik, Tone Shetelig; Ødegård, Rønnaug Astri; Stokkeland, Live Marie T; Andersen, Marianne; Juliusson, Pétur Benedikt; Vanky, Eszter Ilona (Peer reviewed; Journal article, 2023)Introduction Fetal growth may be affected by both maternal polycystic ovary syndrome (PCOS) and metformin therapy. Here, we explore the effect of intrauterine metformin exposure on birth anthropometrics of infants born ... -
App-Delivered Cognitive-Behavioral Therapy for Insomnia Among Patients with Comorbid Musculoskeletal Complaints and Insomnia Referred to 4-Week Inpatient Multimodal Rehabilitation: Protocol for a Randomized Clinical Trial
Skarpsno, Eivind Schjelderup; Simpson, Melanie Rae; Seim, Arnfinn; Hrozanova, Maria; Bakøy, Marthe Alida; Klevanger, Nina Elisabeth; Aasdahl, Lene (Peer reviewed; Journal article, 2023)Background: Insomnia is prevalent among patients receiving treatment for long-term musculoskeletal complaints in inpatient rehabilitation settings. Cognitive-behavioral therapy for insomnia (CBT-I) is effective for improving ... -
Appetite and dietary intake endpoints in cancer cachexia clinical trials: Systematic Review 2 of the cachexia endpoints series
Vagnildhaug, Ola Magne; Balstad, Trude Rakel; Ottestad, Inger; Bye, Asta; Greil, Christine; Arends, Jann; Baracos, Vickie; Brown, Leo R.; Dajani, Olav; Dolan, Ross D.; Fallon, Marie; Fraser, Eilidh; Grzyb, Aleksandra; Hjermstad, Marianne Jensen; Jakobsen, Gunnhild; Kaasa, Stein; McDonald, James; Philips, Iain; Sayers, Judith; Simpson, Melanie Rae; Sousa, Mariana S.; Skipworth, Richard J.E.; Laird, Barry J.A.; Solheim, Tora S (Journal article; Peer reviewed, 2024)There is no consensus on the optimal endpoint(s) in cancer cachexia trials. Endpoint variation is an obstacle when comparing interventions and their clinical value. The aim of this systematic review was to summarize and ... -
Atopic dermatitis prevention in children following maternal probiotic supplementation does not appear to be mediated by breast milk TSLP or TGF-β.
Simpson, Melanie Rae; Rø, Anne Dorthea; Grimstad, Øystein; Johnsen, Roar; Storrø, Ola; Øien, Torbjørn (Journal article; Peer reviewed, 2016)Background: The Probiotics in Prevention of Allergy among Children in Trondheim (ProPACT) study, a randomised, placebo controlled trial, demonstrated that maternal supplementation with probiotic milk reduced the incidence ... -
Beneficial effect of breastfeeding on offspring body weight and asthma: consequence or pre-existing risk profile? Results from The Norwegian Mother, Father and Child Cohort Study
Farsund, Borghild; Ødegård, Rønnaug; Vanky, Eszter; Simpson, Melanie Rae (Master thesis, 2022)Abstract will be available on 2025-12-31 -
Biomarker endpoints in cancer cachexia clinical trials: Systematic Review 5 of the cachexia endpoint series
Yule, Michael S.; Thompson, Joshua; Leesahatsawat, Khachonphat; Sousa, Mariana S.; Anker, Stefan D.; Arends, Jann; Balstad, Trude Rakel; Brown, Leo R.; Bye, Asta; Dajani, Olav; Fallon, Marie; Hjermstad, Marianne Jensen; Jakobsen, Gunnhild; McDonald, James; McGovern, Josh; Roeland, Eric J.; Sayers, Judith; Skipworth, Richard J.E.; Ottestad, Inger; Philips, Iain; Simpson, Melanie Rae; Solheim, Tora S; Vagnildhaug, Ola Magne; McMillan, Donald; Laird, Barry J; Dolan, Ross D. (Journal article; Peer reviewed, 2024)Regulatory agencies require evidence that endpoints correlate with clinical benefit before they can be used to approve drugs. Biomarkers are often considered surrogate endpoints. In cancer cachexia trials, the measurement ... -
Body weight and composition endpoints in cancer cachexia clinical trials: Systematic Review 4 of the cachexia endpoints series
Brown, Leo R.; Sousa, Mariana S.; Yule, Michael S.; Baracos, Vickie E.; McMillan, Donald C.; Arends, Jann; Balstad, Trude Rakel; Bye, Asta; Dajani, Olav; Dolan, Ross D.; Fallon, Marie T.; Greil, Christine; Hjermstad, Marianne Jensen; Jakobsen, Gunnhild; Maddocks, Matthew; McDonald, James; Ottestad, Inger; Phillips, Iain; Sayers, Judith; Simpson, Melanie Rae; Vagnildhaug, Ola Magne; Solheim, Tora S; Laird, Barry J; Skipworth, Richard J.E. (Journal article; Peer reviewed, 2024)Significant variation exists in the outcomes used in cancer cachexia trials, including measures of body composition, which are often selected as primary or secondary endpoints. To date, there has been no review of the most ... -
Breast milk microRNAs: Potential players in oral tolerance development
Ahlberg, Emelie; Al-Kaabawi, Ahmed; Thune, Rebecka; Simpson, Melanie Rae; Pedersen, Sindre Andre; Cione, Erika; Jenmalm, Maria Christina; Tingö, Lina (Journal article; Peer reviewed, 2023) -
Breastfeeding associated microbiota in human milk following supplementation with Lactobacillus rhamnosus GG, Lactobacillus acidophilus La-5 and Bifidobacterium animalis subspecies lactis Bb-12
Simpson, Melanie Rae; Avershina, Ekaterina; Storrø, Ola; Johnsen, Roar; Rudi, Knut; Øien, Torbjørn (Journal article; Peer reviewed, 2017)Breastfeeding is one of the major factors affecting the early development of the infant gut microbiota, and weaning is associated with a shift in the gut microbiota toward a more adult composition. Through breastfeeding, ... -
Bronchial reactivity and asthma at school age after early-life metapneumovirus infection
Myklebust, Åsne; Simpson, Melanie Rae; Valand, Jonas; Langaas, Vibeke Stenhaug; Jartti, Tuomas; Døllner, Henrik; Risnes, Kari (Peer reviewed; Journal article, 2024)Background The association between early-life lower respiratory tract infection (LRTI) and asthma is well established. Knowledge about bronchial hyperresponsiveness (BHR) and asthma after metapneumovirus (MPV) LRTI is ... -
Clinical benefits of modifying the evening light environment in an acute psychiatric unit: A single-centre, two-arm, parallel-group, pragmatic effectiveness randomised controlled trial
Kallestad, Håvard; Langsrud, Knut; Simpson, Melanie Rae; Vestergaard, Cecilie Lund; Vethe, Daniel; Kjørstad, Kaia; Faaland, Patrick Michael Palmelund; Lydersen, Stian; Morken, Gunnar; Ulsaker-Janke, Ingvild; Saksvik, Simen Berg; Scott, Janine Linda (Peer reviewed; Journal article, 2024)Background The impact of light exposure on mental health is increasingly recognised. Modifying inpatient evening light exposure may be a low-intensity intervention for mental disorders, but few randomised controlled ... -
Code-Free Development and Deployment of Deep Segmentation Models for Digital Pathology
Pettersen, Henrik P Sahlin; Belevich, Ilya; Røyset, Elin Synnøve; Smistad, Erik; Simpson, Melanie Rae; Jokitalo, Eija; Reinertsen, Ingerid; Bakke, Ingunn; Pedersen, André (Peer reviewed; Journal article, 2022)Application of deep learning on histopathological whole slide images (WSIs) holds promise of improving diagnostic efficiency and reproducibility but is largely dependent on the ability to write computer code or purchase ... -
Differences in gastrointestinal hormones and appetite ratings between individuals with and without obesity—A systematic review and meta-analysis
Aukan, Marthe Isaksen; Coutinho, Silvia; Pedersen, Sindre Andre; Simpson, Melanie Rae; Martins, Catia (Peer reviewed; Journal article, 2022)Determining if gastrointestinal (GI) hormone response to food intake differs between individuals with, and without, obesity may improve our understanding of obesity pathophysiology. A systematic review and meta-analysis ... -
Digital cognitive-behavioural therapy for insomnia compared with digital patient education about insomnia in individuals referred to secondary mental health services in Norway: Protocol for a multicentre randomised controlled trial
Kallestad, Håvard; Saksvik, Simen Berg; Vedaa, Øystein; Langsrud, Knut; Morken, Gunnar; Lydersen, Stian; Simpson, Melanie Rae; Dørheim, Signe Karen; Holmøy, Bjørn; Germans Selvik, Sara; Hagen, Kristen; Stiles, Tore C; Harvey, Allison G.; Ritterband, Lee M.; Sivertsen, Børge; Scott, Janine Linda (Peer reviewed; Journal article, 2021)Introduction Insomnia is highly prevalent in outpatients receiving treatment for mental disorders. Cognitive–behavioural therapy for insomnia (CBT-I) is a recommended first-line intervention. However, access is limited and ... -
Diversity of vaginal microbiota increases by the time of labor onset
Avershina, Ekaterina; Slangsvold, Silje; Simpson, Melanie Rae; Storrø, Ola; Johnsen, Roar; Øien, Torbjørn; Rudi, Knut (Journal article; Peer reviewed, 2017)Vaginal microbiota is an important early source of bacterial colonization for newborns. However, only a few small studies have investigated the composition of vaginal microbiota during labor. In this work, we analyzed ... -
Domestic violence and pregnancy intendedness: A cross-sectional study in Nepal
Chalise, Pratibha; Infanti, Jennifer Jean; Pun, Kunta Devi; Simpson, Melanie Rae; Henriksen, Lena; Lukasse, Mirjam (Peer reviewed; Journal article, 2025)Background Research indicates that women’s control over their fertility may be impacted by intimate partner and domestic violence. This study aimed to investigate the association between domestic violence and unintended ...