Browsing NTNU Open by Author "Simpson, Melanie Rae"
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Addressing Domestic Violence in Antenatal Care Environments in Nepal (ADVANCE) – study protocol for a randomized controlled trial evaluating a video intervention on domestic violence among pregnant women
Chalise, Pratibha; Manandhar, Pratibha; Infanti, Jennifer Jean; Campbell, Jacquelyn C; Henriksen, Lena; Joshi, Sunil Kumar; Koju, Rajendra; Pun, Kunta Devi; Rishal, Poonam; Simpson, Melanie Rae; Skovlund, Eva; Swahnberg, Katarina; Schei, Berit; Lukasse, Mirjam (Peer reviewed; Journal article, 2023)Background Domestic violence (DV) prior to, and during pregnancy is associated with increased risks for morbidity and mortality. As pregnant women routinely attend antenatal care this environment can be used to offer ... -
Allergy-related diseases and early gut fungal and bacterial microbiota abundances in children
Schei, Kasper; Simpson, Melanie Rae; Øien, Torbjørn; Salamati, Saideh; Rudi, Knut; Ødegård, Rønnaug (Journal article; Peer reviewed, 2021)Background The early gut microbiota has been proposed as an important link between environmental exposures and development of allergy-related diseases. Beyond the widely investigated associations between the gut bacterial ... -
Anthropometrics of neonates born to mothers with PCOS compared to a reference population, - pooled data from three RCTs and The Norwegian Mother, Father and Child Cohort Study (MoBa)
Talmo, Maren Sophie Aaserud; Fløysand, Ingvild Skogedal (Master thesis, 2023)Hensikt: Formålet med oppgaven er å undersøke effekten av polycystisk ovariesyndrom (PCOS) på nyfødtsantropometri og om eventuell effekt påvirkes av mors kroppsmasseindeks (KMI), PCOS fenotype og om hun har svangerskapsdiabetes ... -
Anthropometrics of neonates born to mothers with PCOS compared to a reference population, - pooled data from three RCTs and The Norwegian Mother, Father and Child Cohort Study (MoBa).
Fløysand, Ingvild Skogedal; Talmo, Maren Sophie Aaserud (Master thesis, 2023)Hensikt: Formålet med oppgaven er å undersøke effekten av polycystisk ovariesyndrom (PCOS) på nyfødtsantropometri og om eventuell effekt påvirkes av mors kroppsmasseindeks (KMI), PCOS fenotype og om hun har svangerskapsdiabetes ... -
Anthropometrics of neonates born to mothers with PCOS with metformin or placebo exposure in utero
Nilsen, Guro Ørndal; Simpson, Melanie Rae; Hanem, Liv Guro Engen; Løvvik, Tone Shetelig; Ødegård, Rønnaug Astri; Stokkeland, Live Marie T; Andersen, Marianne; Juliusson, Pétur Benedikt; Vanky, Eszter Ilona (Peer reviewed; Journal article, 2023)Introduction Fetal growth may be affected by both maternal polycystic ovary syndrome (PCOS) and metformin therapy. Here, we explore the effect of intrauterine metformin exposure on birth anthropometrics of infants born ... -
App-Delivered Cognitive-Behavioral Therapy for Insomnia Among Patients with Comorbid Musculoskeletal Complaints and Insomnia Referred to 4-Week Inpatient Multimodal Rehabilitation: Protocol for a Randomized Clinical Trial
Skarpsno, Eivind Schjelderup; Simpson, Melanie Rae; Seim, Arnfinn; Hrozanova, Maria; Bakøy, Marthe Alida; Klevanger, Nina Elisabeth; Aasdahl, Lene (Peer reviewed; Journal article, 2023)Background: Insomnia is prevalent among patients receiving treatment for long-term musculoskeletal complaints in inpatient rehabilitation settings. Cognitive-behavioral therapy for insomnia (CBT-I) is effective for improving ... -
Atopic dermatitis prevention in children following maternal probiotic supplementation does not appear to be mediated by breast milk TSLP or TGF-β.
Simpson, Melanie Rae; Rø, Anne Dorthea; Grimstad, Øystein; Johnsen, Roar; Storrø, Ola; Øien, Torbjørn (Journal article; Peer reviewed, 2016)Background: The Probiotics in Prevention of Allergy among Children in Trondheim (ProPACT) study, a randomised, placebo controlled trial, demonstrated that maternal supplementation with probiotic milk reduced the incidence ... -
Beneficial effect of breastfeeding on offspring body weight and asthma: consequence or pre-existing risk profile? Results from The Norwegian Mother, Father and Child Cohort Study
Farsund, Borghild; Ødegård, Rønnaug; Vanky, Eszter; Simpson, Melanie Rae (Master thesis, 2022)Abstract will be available on 2025-12-31 -
Breast milk microRNAs: Potential players in oral tolerance development
Ahlberg, Emelie; Al-Kaabawi, Ahmed; Thune, Rebecka; Simpson, Melanie Rae; Pedersen, Sindre Andre; Cione, Erika; Jenmalm, Maria Christina; Tingö, Lina (Journal article; Peer reviewed, 2023) -
Breastfeeding associated microbiota in human milk following supplementation with Lactobacillus rhamnosus GG, Lactobacillus acidophilus La-5 and Bifidobacterium animalis subspecies lactis Bb-12
Simpson, Melanie Rae; Avershina, Ekaterina; Storrø, Ola; Johnsen, Roar; Rudi, Knut; Øien, Torbjørn (Journal article; Peer reviewed, 2017)Breastfeeding is one of the major factors affecting the early development of the infant gut microbiota, and weaning is associated with a shift in the gut microbiota toward a more adult composition. Through breastfeeding, ... -
Code-Free Development and Deployment of Deep Segmentation Models for Digital Pathology
Pettersen, Henrik P Sahlin; Belevich, Ilya; Røyset, Elin Synnøve; Smistad, Erik; Simpson, Melanie Rae; Jokitalo, Eija; Reinertsen, Ingerid; Bakke, Ingunn; Pedersen, André (Peer reviewed; Journal article, 2022)Application of deep learning on histopathological whole slide images (WSIs) holds promise of improving diagnostic efficiency and reproducibility but is largely dependent on the ability to write computer code or purchase ... -
Differences in gastrointestinal hormones and appetite ratings between individuals with and without obesity—A systematic review and meta-analysis
Aukan, Marthe Isaksen; Coutinho, Silvia; Pedersen, Sindre Andre; Simpson, Melanie Rae; Martins, Catia (Peer reviewed; Journal article, 2022)Determining if gastrointestinal (GI) hormone response to food intake differs between individuals with, and without, obesity may improve our understanding of obesity pathophysiology. A systematic review and meta-analysis ... -
Digital cognitive-behavioural therapy for insomnia compared with digital patient education about insomnia in individuals referred to secondary mental health services in Norway: Protocol for a multicentre randomised controlled trial
Kallestad, Håvard; Saksvik, Simen Berg; Vedaa, Øystein; Langsrud, Knut; Morken, Gunnar; Lydersen, Stian; Simpson, Melanie Rae; Dørheim, Signe Karen; Holmøy, Bjørn; Germans Selvik, Sara; Hagen, Kristen; Stiles, Tore C; Harvey, Allison G.; Ritterband, Lee M.; Sivertsen, Børge; Scott, Janine Linda (Peer reviewed; Journal article, 2021)Introduction Insomnia is highly prevalent in outpatients receiving treatment for mental disorders. Cognitive–behavioural therapy for insomnia (CBT-I) is a recommended first-line intervention. However, access is limited and ... -
Diversity of vaginal microbiota increases by the time of labor onset
Avershina, Ekaterina; Slangsvold, Silje; Simpson, Melanie Rae; Storrø, Ola; Johnsen, Roar; Øien, Torbjørn; Rudi, Knut (Journal article; Peer reviewed, 2017)Vaginal microbiota is an important early source of bacterial colonization for newborns. However, only a few small studies have investigated the composition of vaginal microbiota during labor. In this work, we analyzed ... -
Duration of breastfeeding, age at introduction of complementary foods and allergy-related diseases: a prospective cohort study
Ekelund, Louise; Gloppen, Inga; Øien, Torbjørn; Simpson, Melanie Rae (Peer reviewed; Journal article, 2021)Background The influences of breastfeeding and infant diet in the prevention of allergy-related diseases are uncertain and many of the studies conducted on the topic are limited by methodological challenges. Our aim was ... -
Early gut fungal and bacterial microbiota and childhood growth
Schei, Kasper; Simpson, Melanie Rae; Avershina, Ekaterina; Rudi, Knut; Øien, Torbjørn; Juliusson, Petur Benedikt; Underhill, David; Salamati, Saideh; Ødegård, Rønnaug (Peer reviewed; Journal article, 2020)Introduction: Childhood growth is a sensitive marker of health. Animal studies show increased height and weight velocity in the presence of fungal as well as antibiotic supplement in feed. Human studies on early gut ... -
The effect of sleep-wake intraindividual variability in digital cognitive behavioral therapy for insomnia: a mediation analysis of a large-scale RCT
Vestergaard, Cecilie Lund; Vedaa, Øystein; Simpson, Melanie Rae; Faaland, Patrick; Vethe, Daniel; Kjørstad, Kaia; Langsrud, Knut; Ritterband, Lee M; Sivertsen, Børge; Stiles, Tore C; Scott, Jan; Kallestad, Håvard (Peer reviewed; Journal article, 2021)Study Objectives Digital cognitive behavioral therapy for insomnia (dCBT-I) is an effective treatment for insomnia. However, less is known about mediators of its benefits. The aim of the present study was to test if ... -
Fish Consumption at One Year of Age Reduces the Risk of Eczema, Asthma and Wheeze at Six Years of Age
Øien, Torbjørn; Schjelvaag, Astrid; Storrø, Ola; Johnsen, Roar; Simpson, Melanie Rae (Journal article; Peer reviewed, 2019)We present a novel liquid array diagnostics (LAD) method, which enables rapid and inexpensive detection of microbial markers in a single-tube multiplex reaction. We evaluated LAD both on pure cultures, and on infant gut ... -
Human Breast Milk miRNA, Maternal Probiotic Supplementation and Atopic Dermatitis in Offspring
Simpson, Melanie Rae; Brede, Gaute; Johansen, Jostein; Johnsen, Roar; Storrø, Ola; Sætrom, Pål; Øien, Torbjørn (Peer reviewed; Journal article, 2015)Background: Perinatal probiotic ingestion has been shown to prevent atopic dermatitis (AD) in infancy in a number of randomised trials. The Probiotics in the Prevention of Allergy among Children in Trondheim (ProPACT) trial ... -
Insights into the quantification and reporting of model-related uncertainty across different disciplines
Simmonds, Emily Grace; Dunn-Sigouin, Etienne; Adjei, Kwaku Peprah; Andersen, Christoffer Wold; Aspheim, Janne Cathrin Hetle; Battistin, Claudia; Bulso, Nicola; Christensen, Hannah M.; Cretois, Benjamin; Cubero, Ryan John Abat; Davidovich, Ivan Andres; Dickel, Lisa; Dunn, Benjamin Adric; Dyrstad, Karin; Einum, Sigurd; Giglio, Donata; Gjerløw, Haakon; Godefroidt, Amélie; González-Gil, Ricardo; Gonzalo Cogno, Soledad; Große, Fabian; Halloran, Paul; Jensen, Mari Fjalstad; Kennedy, John James; Langsæther, Peter Egge; Laverick, Jack H; Lederberger, Debora; Li, Camille; Mandeville, Elizabeth G; Mandeville, Caitlin; Moe, Espen; Schröder, Tobias Navarro; Nunan, David; Sicacha-Parada, Jorge; Simpson, Melanie Rae; Skarstein, Emma Sofie; Spensberger, Clemens; Stevens, Richard; Subramanian, Aneesh C.; Svendsen, Lea; Theisen, Ole Magnus; Watret, Connor; O'Hara, Robert B. (Peer reviewed; Journal article, 2022)Quantifying uncertainty associated with our models is the only way we can express how much we know about any phenomenon. Incomplete consideration of model-based uncertainties can lead to overstated conclusions with real-world ...