Blar i NTNU Open på forfatter "Simic, Nebojsa"
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A novel compound isolated from Sclerochloa dura has anti-inflammatory effects
Bukhari, Syed Majid; Feuerherm, Astrid Jullumstrø; Tunset, Hanna Maja; Isaksen, Stian Moe; Sæther, Mari; Thvedt, Thor Håkon Krane; Villa Gonzalez, Susana; Schmid, Rudolf; Brunsvik, Anders; Fuglseth, Erik; Zlatković, Bojan; Johansen, Berit; Simic, Nebojsa (Journal article; Peer reviewed, 2016)The activation of phospholipase A2 (PLA2) by means of pro-inflammatory cytokines results in the subsequent release of arachidonic acid (AA) and generates eicosanoids, which further propagate inflammation. Through cyclooxygenases ... -
Anti-inflammatory and antioxidant activities of Sclerochloa dura (Poaceae)
Bukhari, Syed Majid; Feuerherm, Astrid Jullumstrø; Boulfrad, Fayssal; Zlatkovic, Bojan; Johansen, Berit; Simic, Nebojsa (Journal article; Peer reviewed, 2014)The plant Sclerochloa dura is traditionally used in South-East Serbia to treat menstrual disorders characterized by pain and excessive bleeding. According to subjects’ statements, a reduction in bleeding and pain is ... -
Benzoylated uronic acid building blocks and synthesis of N-uronate conjugates of lamotrigine
Esmurziev, Aslan; Reimers, Arne; Andreassen, Trygve; Simic, Nebojsa; Sundby, Eirik; Hoff, Bård Helge (Journal article; Peer reviewed, 2012)A chemoenzymatic approach towards benzoylated uronic acid building blocks has been investigated starting with benzoylated hexapyranosides using regioselective C-6 enzymatic hydrolysis as the key step. Two of the building ... -
Benzoylated uronic Acid building blocks and synthesis of N-uronate conjugates of lamotrigine
Esmurziev, Aslan; Reimers, Arne; Andreassen, Trygve; Simic, Nebojsa; Sundby, Eirik; Hoff, Bård Helge (Journal article; Peer reviewed, 2012)chemoenzymatic approach towards benzoylated uronic acid building blocks has been investigated starting with benzoylated hexapyranosides using regioselective C-6 enzymatic hydrolysis as the key step. Two of the building ... -
Bioassay-guided isolation and identification of anti-inflammatory compounds in Sclerochloa Dura
Chandran, Losshenee (Master thesis, 2018)Sclerochloa dura was known to have anti-inflammatory properties and the aim of this thesis is to isolate and identify compounds that are present in fractions and has high inhibition level against arachidonic acid (AA) when ... -
Chemical Analysis and Anthelmintic Activity Against Teladorsagia Circumcincta of Nordic Bark Extracts In vitro
Athanasiadou, Spiridoula; Almvik, Marit; Hellström, Jarkko; Madland, Eva; Simic, Nebojsa; Steinshamn, Håvard (Peer reviewed; Journal article, 2021)Helminth parasitic infections are common in small ruminants in Norway; infection is usually treated with anthelmintic drugs, but anthelmintic resistance is an increasing problem. It is necessary to identify strategies to ... -
Elucidated structures from traditional Nigerian medicinal plants
Verkerk, Robin (Master thesis, 2022)Oppgavens mål er å oppklare strukturene til stoffer ekstrahert fra Laportea aestuans, Colocasia esculenta, Xylopia aethiopica and Raphiostylis beninensis, tradisjonelle nigerianske medisinske planter. Motivasjone for dette ... -
Extraction, Isolation and Structure Elucidation of Saponins from Herniaria incana
Madland, Eva (Master thesis, 2013)Species of the Herniaria genus have been reported to have several medicinal uses. Two of the species from this genus, Herniaria glabra and Herniaria hirsuta, have both been documented to contain saponins. This can explain ... -
Fabrication of novel polymeric membranes for CO2 gas separation
Kroyan, Arpenik (Master thesis, 2019) -
Genome Mining of Streptomyces sp. YIM 130001 Isolated From Lichen Affords New Thiopeptide Antibiotic
Schneider, Olha; Simic, Nebojsa; Aachmann, Finn Lillelund; Rückert, Christian; Kristiansen, Kåre Andre; Kalinowski, Jörn; Jiang, Yi; Wang, Lisong; Jiang, Cheng-Lin; Lale, Rahmi; Zotchev, Sergey B (Journal article; Peer reviewed, 2018)Streptomyces bacteria are recognized as an important source for antibiotics with broad applications in human medicine and animal health. Here, we report the isolation of a new lichen-associating Streptomyces sp. YIM 130001 ... -
Identification and Characterization of a Streptomyces albus Strain and Its Secondary Metabolite Organophosphate against Charcoal Rot of Sorghum
Gopalakrishnan, Subramaniam; Sharma, Rajan; Srinivas, Vadlamudi; Naresh, Nimmala; Mishra, Suraj P.; Ankati, Sravani; Pratyusha, Sambangi; Govindaraj, Mahalingam; Villa Gonzalez, Susana; Nervik, Sondre; Simic, Nebojsa (Peer reviewed; Journal article, 2020)Streptomycesalbus strain CAI-21 has been previously reported to have plant growth-promotion abilities in chickpea, pigeonpea, rice, and sorghum. The strain CAI-21 and its secondary metabolite were evaluated for their ... -
Initial investigations into the synthesis of 1-O-(3-deoxy-3-linolenoyl-amide-sulfoquinovosyl) glycerol
Tveit, Johannes (Master thesis, 2021)Arbeidet som er presentert i denne oppgaven har vært en del av forskningen på totalsyntesen av 1-O-(3-O-linolenoyl-6-deoksy-6-sulfo-a-D-glukopyranosyl)-glyserol (1) og dets derivater. Målet med arbeidet var å undersøke ... -
Investigation of protection group exchange in late stage intermediates in the synthesis of 3-O-acylsulfoquinovosyl glycerols
Stene, Ragnar (Master thesis, 2021)Arbeidet presentert i denne masteroppgaven ble utført som en del av et forskningsprosjekt hvor målet er å totalsyntetisere 3-O-acylsulfokinovosyl glyseroler, basert på et naturlig stoff ekstrahert fra Schlerochloa dura. ... -
Isolation and determination of flavonoids in Herniaria incana
Swiergon, Wojciech (Master thesis, 2021) -
Recent advances in NMR structure elucidation of small organic molecules
Hundershagen, Linn (Bachelor thesis, 2020) -
Regioselective Protection and Functionalization of C-6 in The Synthesis Towards Sulfoquinovoses
Bjørnstad, Frithjof Andreas (Master thesis, 2018)The main goal of this thesis was to explore and compare two protection strategies yielding 2,3,4-tri-O-benzyl-α-D-glucopyranosides. Further work was done to functionalize the primary 6- hydroxyl position to a sulfonic acid ... -
Selective Functionalization of Glucose
Vonderlind, Hendrick-Thorn Axel (Bachelor thesis, 2023)I denne teksten vil vi skrive og diskutere om emnet selektivt funksjonaliserende glukose. Inkludert ulike metoder for å oppnå selektiv funksjonalisering og effektene det kan ha på forbindelsen. Glukose er et molekyl som ... -
Selective functionalization of α-D-glucopyranosides in the synthesis towards sugar fatty acid esters
Stenset, Edvard Solli (Master thesis, 2019)Som en del av et større synteseprosjekt ble utvalgte reaksjoner, nyttige i den overordnede syntesestrategien, utforsket. Regioselektiv beskyttelse av allylerte α-D-glukopyranosider, esterifisering og videre avbeskyttelse ... -
Synthesis and Structure Elucidation of Benzoylated Deoxyfluoropyranosides
Esmurziev, Aslan M.; Simic, Nebojsa; Hoff, Bard Helge; Sundby, Eirik (Journal article; Peer reviewed, 2010)Benzoylated deoxyfluoropyranosides have been synthesized, starting with protected, unprotected, or fluorinated precursors. Fluorination of eight derivatives was compared using DAST and Deoxo-Fluor as reagents. Deoxo-Fluor ... -
Synthesis of 3'-O-esterified sulfoquinovosyl glycerol derivatives
Nervik, Sondre (Doctoral theses at NTNU;2022:282, Doctoral thesis, 2022)Lipid secondary metabolites are increasingly receiving the attention of researchers for their nutritional and pharmaceutical properties. In a previous study on secondary metabolites of Sclerochloa dura, a plant used in ...