• Catalyzing transcriptomics research in cardiovascular disease: The CardioRNA COST action CA17129 

      da Costa Gomes, Clarissa Pedrosa; Ágg, Bence; Andova, Andrejaana; Arslan, Serdal; Baker, Andrew; Barteková, Monika; Beis, Dimitris; Betsou, Fay; Wettinger, Stephanie Bezzina; Bugarski, Branko; Condorelli, Gianluigi; Silva, Gustavo Jose Justo; Danilin, Sabrina; de Gonzalo-Calvo, David; Buil, Alfonso; Carmo-Fonseca, Maria; Enguita, Francisco J.; Felekkis, Kyriacos; Ferdinandy, Peter; Gyöngyösi, Mariann; Hackl, Matthias; Karaduzovic-Hadziabdic, Kanita; Hellemans, Jan; Heymans, Stephane; Hlavackova, Markéta; Høydal, Morten; Jankovic, Aleksandra; Jusic, Amela; Kardassis, Dimitris; Kerkelä, Risto; Kuster, Gabriela M.; Lakkisto, Päivi; Leszek, Przemyslaw; Lustrek, Mitja; Maegdefessel, Lars; Martelli, Fabio; Novella, Susana; O’Brien, Timothy; Papaneophytou, Christos; Pedrazzini, Thierry; Pinet, Florence; Popescu, Octavian; Potočnjak, Ines; Robinson, Emma; Sasson, Shlomo; Scholz, Markus; Simionescu, Maya; Stoll, Monika; Varga, Zoltán V.; Vinciguerra, Manlio; Xuereb, Angela; Yilmaz, Mehmet Birhan; Emanueli, Costanza; Devaux, Yvan (Journal article; Peer reviewed, 2019)
      Cardiovascular disease (CVD) remains the leading cause of death worldwide and, despite continuous advances, better diagnostic and prognostic tools, as well as therapy, are needed. The human transcriptome, which is the set ...
    • Circulating microRNAs May Serve as Biomarkers for Hypertensive Emergency End-Organ Injuries and Address Underlying Pathways in an Animal Model 

      Langlo, Knut Asbjørn Rise; Silva, Gustavo Jose Justo; Overrein, Tina Syvertsen; Adams, Volker; Wisløff, Ulrik; Dalen, Håvard; Rolim, Natale Pinheiro Lage; Hallan, Stein (Journal article; Peer reviewed, 2021)
      There is an incomplete understanding of the underlying pathophysiology in hypertensive emergencies, where severely elevated blood pressure causes acute end-organ injuries, as opposed to the long-term manifestations of ...
    • Differential regulation of cysteine oxidative post-translational modifications in high and low aerobic capacity 

      Souza, Rodrigo W. A.; Alves, Christiano R. R.; Medeiros, Alessandra; Rolim, Natale Pinheiro Lage; Silva, Gustavo Jose Justo; Moreira, Jose Bianco Nascimento; Alves, Marcia Netto Magalhaes; Wohlwend, Martin; Gebriel, Mohammed; Hagen, Lars; Sharma, Animesh; Koch, Lauren G.; Britton, Steven L.; Slupphaug, Geir; Wisløff, Ulrik; Brum, Patricia C. (Journal article; Peer reviewed, 2018)
      Given the association between high aerobic capacity and the prevention of metabolic diseases, elucidating the mechanisms by which high aerobic capacity regulates whole-body metabolic homeostasis is a major research challenge. ...
    • Exercise training reveals inflexibility of the diaphragm in an animal model of patients with obesity-driven heart failure with a preserved ejection fraction 

      Bowen, T Scott; Brauer, Dominic; Rolim, Natale Pinheiro Lage; Bækkerud, Fredrik Hjulstad; Kricke, Angela; Berre, Anne Marie Ormbostad; Fischer, Tina; Linke, Axel; Silva, Gustavo Jose Justo; Wisløff, Ulrik; Adams, Volker (Journal article; Peer reviewed, 2017)
      Background Respiratory muscle weakness contributes to exercise intolerance in patients with heart failure with a preserved ejection fraction (HFpEF)—a condition characterized by multiple comorbidities with few proven ...
    • Identification of novel genetic variants associated with cardiorespiratory fitness 

      Bye, Anja; Klevjer, Marie; Ryeng, Einar; Silva, Gustavo Jose Justo; Moreira, Jose Bianco Nascimento; Stensvold, Dorthe; Wisløff, Ulrik (Peer reviewed; Journal article, 2020)
      Introduction Low maximal oxygen uptake (VO2max) is a strong and independent risk factor for all-cause and cardiovascular disease (CVD) mortality. For other CVD risk factors, numerous genetic association studies have been ...