Blar i NTNU Open på forfatter "Sikorski, Pawel"
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A correlative spatiotemporal microscale study of calcium phosphate formation and transformation within an alginate hydrogel matrix.
Bassett, David; Ucar, Seniz; Sikorski, Pawel; Andreassen, Jens-Petter; Bjørnøy, Sindre Hove; Strand, Berit Løkensgard (Journal article; Peer reviewed, 2016)The modification of soft hydrogels with hard inorganic components is a method used to form composite materials with application in non-load-bearing bone tissue engineering. The inclusion of an inorganic component may provide ... -
Analysis of Actin and Focal Adhesion Organisation in U2OS Cells on Polymer Nanostructures
Vinje, Jakob; Guadagno, Noemi Antonella; Progida, Cinzia; Sikorski, Pawel (Peer reviewed; Journal article, 2021)Background In this work, we explore how U2OS cells are affected by arrays of polymer nanopillars fabricated on flat glass surfaces. We focus on describing changes to the organisation of the actin cytoskeleton and in the ... -
Application of Temporary, Cell-Containing Alginate Microcarriers to Facilitate the Fabrication of Spatially Defined Cell Pockets in 3D Collagen Hydrogels
Lehnert, Sarah; Sikorski, Pawel (Journal article; Peer reviewed, 2021)Mimicking the complexity of natural tissue is a major challenge in the field of tissue engineering. Here, a facile 2-step fabrication method to prepare 3D constructs with distinct regions of high cell concentrations and ... -
Bio-instructive materials for musculoskeletal regeneration
Gonzalez-Fernandez, Tomas; Sikorski, Pawel; Leach, J. Kent (Journal article; Peer reviewed, 2019)The prevalence and cost of disorders affecting the musculoskeletal system are predicted to rise significantly in the coming years due to the aging global population and the increase of associated risk factors. Despite being ... -
Biochemical and Structural Characterization of Neocartilage Formed by Mesenchymal Stem Cells in Alginate Hydrogels
Magnus Østgård, Olderøy; Lilledahl, Magnus Borstad; Beckwith, Marianne; Melvik, Jan Egil; Reinholt, Finn P.; Sikorski, Pawel; Brinchmann, Jan E. (Journal article; Peer reviewed, 2014)A popular approach to make neocartilage in vitro is to immobilize cells with chondrogenic potential in hydrogels. However, functional cartilage cannot be obtained by control of cells only, as function of cartilage is largely ... -
Biocomposites prepared by alkaline phosphatase mediated mineralization of alginate microbeads
Xie, Minli; Magnus Østgård, Olderøy; Zhang, Zhibing; Andreassen, Jens-Petter; Strand, Berit Løkensgard; Sikorski, Pawel (Journal article; Peer reviewed, 2012)This study set out to develop a biomimetic scaffold by incorporating osteoinductive hydroxyapatite (HA) particles into a porous alginate gel matrix via a cell-friendly pathway. Two types of alginate/calcium phosphate ... -
Bioengineered Neural Networks as Computational Systems: Designing Anatomically Inspired Microcircuits to Decode Neural Function and Dysfunction
Winter-Hjelm, Nicolai (Doctoral theses at NTNU;2024:355, Doctoral thesis, 2024)Engineered neural networks provide invaluable platforms for studying neural function and dysfunction within controlled microenvironments. Recent advancements in engineered interfaces, such as multinodal microfluidic platforms ... -
Calcite seed-assisted microbial induced carbonate precipitation (MICP)
Zehner, Jennifer Simone; Røyne, Anja; Sikorski, Pawel (Peer reviewed; Journal article, 2021)Microbial-induced calcium carbonate precipitation (MICP) is a biological process inducing biomineralization of CaCO3. This can be used to form a solid, concrete-like material. To be able to use MICP successfully to produce ... -
Coherent Anti-Stokes Raman Scattering (CARS) microscopy of calcium phosphate minerals and bone samples
Konarboland, André (Master thesis, 2024)Bein er et viktig og multifunksjonelt organ, men på grunn av en aldrende befolkning har det vært en økning i sykdommer som osteoporose eller lignende tilstander. Det er derfor behov for videre studier av nanoskalaprosessene ... -
Competitive ligand exchange of crosslinking ions for ionotropic hydrogel formation.
Bassett, David; Håti, Armend Gazmeno; Melø, Thor Bernt; Stokke, Bjørn Torger; Sikorski, Pawel (Journal article; Peer reviewed, 2016)Currently there are limitations to gelation strategies to form ionically crosslinked hydrogels, derived in particular from a lack of control over the release kinetics of crosslinking ions, which severely restrict applications. ... -
Controlled mineralisation and recrystallisation of brushite within alginate hydrogels
Bjørnøy, Sindre Hove; Bassett, David; Ucar, Seniz; Sikorski, Pawel; Andreassen, Jens-Petter (Journal article; Peer reviewed, 2016-02)Due to high solubility and fast resorption behaviour under physiological conditions, brushite (CaHPO4⋅2H2O, calcium monohydrogen phosphate dihydrate, dicalcium phosphate dihydrate) has great potential in bone regeneration ... -
Developing 2.5D Nanotopographical in vitro Neural Network Recording Platform to Mimic the Physical Environment of the Brain
Isdal, Leik Bjelland (Master thesis, 2021)På tross av sin vanvittige kompleksitet er nervesystemet en del av menneskets anatomi som er spesielt sårbar. Nevrodegenerative sykdommer som Alzheimers og Parkinsons forårsaker omfattende og uopprettelig skade hos de som ... -
Development of a tailored microfluidic platform with improved electrical signal detection for in vitro studies of neural networks and neural network pathology
Winter-Hjelm, Nicolai (Master thesis, 2020)Menneskets nervesystem utgjør verdens mest avanserte evolusjonære maskineri. Gjennom dets høyst intrikate arkitektur og beregningsevner kontrollerer det oppgaver så funksjonelt forskjellige som muskelbevegelser og lagring ... -
Dissolution of copper mineral phases in biological fluids and the controlled release of copper ions from mineralized alginate hydrogels
Bassett, David; Madzovska, Ivana; Beckwith, Kai Sandvold; Melø, Thor Bernt; Sikorski, Pawel; Obradovic, Bojana (Journal article; Peer reviewed, 2015)Here we investigate the dissolution behaviour of copper minerals contained within biocompatible alginate hydrogels. Copper has a number of biological effects and has most recently been evaluated as an alternative to expensive ... -
Effects of Nanostructured SU-8 Surfaces on Neurons and Neural Networks in Vitro
Hvide, Edevard (Master thesis, 2021)Nanotopografiske vekstflater har de siste årene blitt anvendt som en lovende strategi for å øke topologisk kompleksitet av biologiske nevrale nettverk dyrket på in vitro forskningsplattformer. Slike plattformer kan ... -
Electroconductive scaffolds for tissue engineering applications
Sikorski, Pawel (Journal article, 2020)Many material systems that can conduct electronic current have been in recent years studied in the context of tissue engineering. It is suggested that materials that can carry electronic current are necessary or beneficial ... -
Electron Beam Lithography Fabrication of SU-8 Polymer Structures for Cell Studies
Vinje, Jakob; Beckwith, Kai Sandvold; Sikorski, Pawel (Journal article; Peer reviewed, 2020)Flat surfaces decorated with micro- and nanostructures are important tools in biomedical research used to control cellular shape, in studies of mechanotransduction, membrane mechanics, cell migration and cellular interactions ... -
Evidence for egg-box-compatible interactions in calcium-alginate gels from fiber X-ray diffraction
Sikorski, Pawel; Mo, Frode; Skjåk-Bræk, Gudmund; Stokke, Bjørn Torger (Peer reviewed; Journal article, 2007)The structures of guluronic-acid-rich alginate in the acid and calcium forms were investigated using fiber X-ray diffraction. Data recorded for alginate fibers in the acid form show a repeat along the chain axis of c = ... -
Formation of Hydroxyapatite via Transformation of Amorphous Calcium Phosphate in the Presence of Alginate Additives
Ucar, Seniz; Bjørnøy, Sindre Hove; Bassett, David; Strand, Berit Løkensgard; Sikorski, Pawel; Andreassen, Jens-Petter (Journal article; Peer reviewed, 2019)Hydroxyapatite (HA) is the primary mineral of vertebral tooth and bone tissue; thus, it is often incorporated into synthetic composite materials designed for hard tissue engineering applications. Understanding the formation ... -
Gelling kinetics and in situ mineralization of alginate hydrogels: A correlative spatiotemporal characterization toolbox.
Åslund, Andreas; Bassett, David; Ucar, Seniz; Sikorski, Pawel; Andreassen, Jens-Petter; Mandaric, Stefan; Bjørnøy, Sindre Hove; Strand, Berit Løkensgard (Journal article; Peer reviewed, 2016)Due to their large water content and structural similarities to the extracellular matrix, hydrogels are an attractive class of material in the tissue engineering field. Polymers capable of ionotropic gelation are of special ...