• Clinical Risk Factors For Kidney Tubule Biomarker Abnormalities Among Hypertensive Adults With Reduced eGFR in the SPRINT Trial 

      Ikeme, Jesse C.; Katz, Ronit; Muiru, Anthony N.; Estrella, Michelle M.; Scherzer, Rebecca; Garimella, Pranav S.; Hallan, Stein; Peralta, Carmen A.; Ix, Joachim H.; Shlipak, Michael G. (Peer reviewed; Journal article, 2022)
      BACKGROUND Urine biomarkers of kidney tubule health may distinguish aspects of kidney damage that cannot be captured by current glomerular measures. Associations of clinical risk factors with specific kidney tubule ...
    • Estimated Kidney Tubular Secretion and Kidney, Cardiovascular, and Mortality Outcomes in CKD: The Systolic Blood Pressure Intervention Trial 

      Ascher, Simon B.; Shlipak, Michael G.; Katz, Ronit; Bullen, Alexander L.; Scherzer, Rebecca; Hallan, Stein; Cheung, Alfred K.; Raphael, Kalani L.; Estrella, Michelle M.; Jotwani, Vasantha K.; Seegmiller, Jesse C.; Ix, Joachim H.; Garimella, Pranav S. (Peer reviewed; Journal article, 2022)
      Rational & Objective Many drugs, metabolites, and toxins are cleared by the kidneys via tubular secretion. Whether novel endogenous measures of tubular secretion provide information about kidney, cardiovascular, and ...
    • Low thyroid function is not associated with an accelerated deterioration in renal function 

      Meuwese, Christiaan L.; van Diepen, Merel; Cappola, Anne R.; Sarnak, Mark J.; Shlipak, Michael G.; Bauer, Douglas C.; Fried, Linda P.; Iacoviello, Massimo; Vaes, Bert; Degryse, Jean; Khaw, Kay-Tee; Luben, Robert N.; Åsvold, Bjørn Olav; Bjøro, Trine; Vatten, Lars Johan; de Craen, Anton J.M.; Trompet, Stella; Iervasi, Giorgio; Molinaro, Sabrina; Ceresini, Graziano; Ferrucci, Luigi; Dullaart, Robin P.F.; Bakker, Stephan J.L.; Jukema, J. Wouter; Kearney, Patricia M.; Stott, David J.; Peeters, Robin P.; Franco, Oscar H.; Völzke, Henry; Walsh, John P.; Bremner, Alexandra; Sgarbi, José A.; Maciel, Rui M.B.; Imaizumi, Misa; Ohishi, Waka; Dekker, Friedo W.; Rodondi, Nicolas; Gussekloo, Jacobijn; den Elzen, Wendy P.J. (Peer reviewed; Journal article, 2019)
      Background Chronic kidney disease (CKD) is frequently accompanied by thyroid hormone dysfunction. It is currently unclear whether these alterations are the cause or consequence of CKD. This study aimed at studying the ...
    • Markers of Kidney Tubular Secretion and Risk of Adverse Events in SPRINT Participants with CKD 

      Bullen, Alexander L.; Ascher, Simon B.; Scherzer, Rebecca; Garimella, Pranav S.; Katz, Ronit; Hallan, Stein; Cheung, Alfred K.; Raphael, Kalani L.; Estrella, Michelle M.; Jotwani, Vasantha K.; Malhotra, Rakesh; Seegmiller, Jesse C.; Shlipak, Michael G.; Ix, Joachim H. (Peer reviewed; Journal article, 2022)
      Significance Statement SPRINT demonstrated in individuals with hypertension and high cardiovascular disease (CVD) risk that intensive BP lowering was associated with decreased risk of CVD events and all-cause mortality. ...
    • Relationship of estimated GFR and albuminuria to concurrent laboratory abnormalities: An individual participant data meta-analysis in a global consortium 

      Inker, Lesley A.; Grams, Morgan E.; Levey, Andrew S.; Coresh, Josef; Cirillo, Massimo; Collins, John F.; Gansevoort, Ron T.; Gutierrez, Orlando M.; Hamano, Takayuki; Heine, Gunnar H.; Ishikawa, Shizukiyo; Jee, Sun Ha; Kronenberg, Florian; Landray, Martin J.; Miura, Katsuyuki; Nadkarni, Girish N.; Peralta, Carmen A.; Rothenbacher, Dietrich; Schaeffner, Elke; Sedaghat, Sanaz; Shlipak, Michael G.; Zhang, Luxia; van Zuilen, Arjan D.; Hallan, Stein; Kovesdy, Csaba P.; Woodward, Mark; Levin, Adeera (Peer reviewed; Journal article, 2018)
      Rationale & Objective Chronic kidney disease (CKD) is complicated by abnormalities that reflect disruption in filtration, tubular, and endocrine functions of the kidney. Our aim was to explore the relationship of specific ...
    • Structured Moderate Exercise and Biomarkers of Kidney Health in Sedentary Older Adults: The Lifestyle Interventions and Independence for Elders Randomized Clinical Trial 

      Sheshadri, Anoop; Lai, Mason; Hsu, Fang-Chi; Bauer, Scott R.; Chen, Shyh-Huei; Tse, Warren; Jotwani, Vasantha; Tranah, Gregory J.; Lai, Jennifer C.; Hallan, Stein Ivar; Fielding, Roger A.; Liu, Christine; Ix, Joachim H.; Coca, Steven G.; Shlipak, Michael G. (Peer reviewed; Journal article, 2023)
      Rationale & Objective In the Lifestyle Interventions and Independence for Elders (LIFE) trial, a structured exercise intervention slowed kidney function decline in sedentary older adults. Biomarkers of kidney health could ...