• 18F-Fluciclovine PET/MRI for preoperative lymph node staging in high-risk prostate cancer patients 

      Selnæs, Kirsten Margrete; Krüger-Stokke, Brage; Elschot, Mattijs; Willoch, Frode; Størkersen, Øystein; Sandsmark, Elise; Moestue, Siver Andreas; Tessem, May-Britt; Halvorsen, Dag; Kjøbli, Eirik; Angelsen, Anders; Langørgen, Sverre; Bertilsson, Helena; Bathen, Tone Frost (Journal article; Peer reviewed, 2018)
      Objective To investigate the diagnostic potential of simultaneous 18F-fluciclovine PET/MRI for pelvic lymph node (LN) staging in patients with high-risk prostate cancer. Methods High-risk prostate cancer patients (n=28) ...
    • A novel non-canonical Wnt signature for prostate cancer aggressiveness 

      Sandsmark, Elise; Hansen, Ailin Falkmo; Selnæs, Kirsten Margrete; Bertilsson, Helena; Bofin, Anna M.; Wright, Alan J.; Viset, Trond; Richardsen, Elin; Drabløs, Finn Sverre; Bathen, Tone Frost; Tessem, May-Britt; Rye, Morten Beck (Journal article; Peer reviewed, 2016)
      Activation of the Canonical Wnt pathway (CWP) has been linked to advanced and metastatic prostate cancer, whereas the Wnt5a-induced non-canonical Wnt pathway (NCWP) has been associated with both good and poor prognosis. A ...
    • A PET/MRI study towards finding the optimal [18F]Fluciclovine PET protocol for detection and characterisation of primary prostate cancer. 

      Elschot, Mattijs; Selnæs, Kirsten Margrete; Sandsmark, Elise; Krüger-Stokke, Brage; Størkersen, Øystein; Tessem, May-Britt; Moestue, Siver Andreas; Bertilsson, Helena; Bathen, Tone Frost (Journal article; Peer reviewed, 2016)
      Purpose: [18F]Fluciclovine PET imaging shows promise for the assessment of prostate cancer. The purpose of this PET/MRI study is to optimise the PET imaging protocol for detection and characterisation of primary prostate ...
    • A Retrospective Follow-up Study of Patients with Negative Multiparametric Prostate MRI 

      Jensen, Audun Bakke (Master thesis, 2023)
      Bakgrunn: Det er ikke allment akseptert at det er trygt og ønskelig å avstå fra biopsi i tilfeller av negativ multiparametrisk MR (mpMR) av prostata hos biopsinaive menn. Denne studien er en retrospektiv oppfølgingsstudie ...
    • A Single-Arm, Multicenter Validation Study of Prostate Cancer Localization and Aggressiveness With a Quantitative Multiparametric Magnetic Resonance Imaging Approach. 

      Maas, Marnix C; Litjens, Geert; Wright, A. J.; Attenberger, UI; Haider, MA; Helbich, Thomas H.; Kiefer, B; Macura, KJ; Margolis, David Joel; Padhani, AR; Selnæs, Kirsten Margrete; Villeirs, GM; Futterer, Jürgen J.; Scheenen, Tom WJ (Journal article; Peer reviewed, 2019)
      Objectives: The aims of this study were to assess the discriminative performance of quantitative multiparametric magnetic resonance imaging (mpMRI) between prostate cancer and noncancer tissues and between tumor grade ...
    • Assessing RF-Induced Heating of Orthopedic Implants in Ultra-High Field MRI: Influencing Factors and the Effect of Parallel Transmission 

      Halvorsen, Dan Kristina (Master thesis, 2023)
      Dette studiet undersøker radiofrekvens (RF)-indusert oppvarming av ulike implantater i et gelhodefantom ved bruken av 7T magnetresonanstomografi (MRI). Utviklingen mot høyere statisk magnetfeltstyrker i MRI har ført til ...
    • Automated reference tissue normalization of T2-weighted MR images of the prostate using object recognition 

      Sunoqrot, Mohammed R. S.; Nketiah, Gabriel Addio; Selnæs, Kirsten Margrete; Bathen, Tone Frost; Elschot, Mattijs (Peer reviewed; Journal article, 2020)
      Objectives To develop and evaluate an automated method for prostate T2-weighted (T2W) image normalization using dual-reference (fat and muscle) tissue. Materials and methods Transverse T2W images from the publicly ...
    • Combined 18F-Fluciclovine PET/MRI shows potential for detection and characterization of high-risk prostate cancer 

      Elschot, Mattijs; Selnæs, Kirsten Margrete; Sandsmark, Elise; Krüger-Stokke, Brage; Størkersen, Øystein; Giskeødegård, Guro F.; Tessem, May-Britt; Moestue, Siver Andreas; Bertilsson, Helena; Bathen, Tone Frost (Journal article; Peer reviewed, 2017)
      The objective of this study is to investigate if quantitative imaging features derived from combined 18F-Fluciclovine Positron Emission Tomograpy (PET) / multiparametric Magnetic Resonance Imaging (MRI) show potential for ...
    • A comparison of Generative Adversarial Networks for automated prostate cancer detection on T2-weighted MRI 

      Patsanis, Alexandros; Sunoqrot, Mohammed R. S.; Langørgen, Sverre; Wang, Hao; Selnæs, Kirsten Margrete; Bertilsson, Maria Helena; Bathen, Tone Frost; Elschot, Mattijs (Journal article; Peer reviewed, 2023)
      Generative Adversarial Networks (GANs) have shown potential in medical imaging. In this study, several previously developed GANs were investigated for prostate cancer (PCa) detection on T2-weighted (T2W) magnetic resonance ...
    • Computer-Aided Diagnosis of Prostate Cancer Using Multiparametric MRI: Preprocessing, Segmentation and Quality Control 

      Sunoqrot, Mohammed Rasem Sadeq (Doctoral theses at NTNU;2021:264, Doctoral thesis, 2021)
      Sammendrag Dataassistert diagnostikk av prostatakreft ved bruk av Multiparametrisk MRI: Forbehandling, segmentering og kvalitetskontroll Prostatakreft er den vanligste kreftformen hos menn og den nest hyppigste årsaken ...
    • Detection of recurrent prostate cancer with 18F-Fluciclovine PET/MRI 

      Selnæs, Kirsten Margrete; Krüger-Stokke, Brage; Elschot, Mattijs; Johansen, Håkon; Steen, Per Arvid; Langørgen, Sverre; Aksnessæther, Bjørg Yksnøy; Indrebø, Gunnar; Sjøbakk, Torill Eidhammer; Tessem, May-Britt; Moestue, Siver Andreas; Knobel, Heidi; Tandstad, Torgrim; Bertilsson, Helena; Solberg, Arne; Bathen, Tone Frost (Peer reviewed; Journal article, 2020)
      Objective: Simultaneous PET/MRI combines soft-tissue contrast of MRI with high molecular sensitivity of PET in one session. The aim of this prospective study was to evaluate detection rates of recurrent prostate cancer by ...
    • Ex vivo metabolic fingerprinting identifies biomarkers predictive of prostate cancer recurrence following radical prostatectomy 

      Braadland, Peder; Giskeødegård, Guro F.; Sandsmark, Elise; Bertilsson, Helena; Euceda, Leslie R.; Hansen, Ailin Falkmo; Guldvik, Ingrid Jenny; Selnæs, Kirsten Margrete; Grytli, Helene Hartvedt; Katz, Betina; Svindland, Aud; Bathen, Tone Frost; Eri, Lars Magne; Nygård, Ståle; Berge, Viktor; Tasken, Kristin Austlid; Tessem, May-Britt (Journal article; Peer reviewed, 2017)
      Background: Robust biomarkers that identify prostate cancer patients with high risk of recurrence will improve personalised cancer care. In this study, we investigated whether tissue metabolites detectable by high-resolution ...
    • Magnetic Resonance Imaging (MRI) Quality Assurance Phantom and Protocol 

      Gyebi, Alex Gyamfi (Master thesis, 2023)
      Mål: Foreslå og designe en billig, lett produsert, og svært effektiv alternativ kvalitetskontroll fantom og medfølgende måleprotokoll for MRI kvalitetskontroll. Materiale og Metoder: Allment tilgjengelige og billige ...
    • Magnetic Resonance Imaging for Improved Prostate Cancer Diagnosis 

      Nketiah, Gabriel Addio (Doctoral theses at NTNU;2018:82, Doctoral thesis, 2018)
      Magnetic Resonance Imaging for Improved Prostate Cancer Diagnosis Prostate cancer is one of the major menaces to the health of men worldwide. With approximately one in every eight men affected during their lifetime, it ...
    • Metabolic and Histopathological characterization of Prostate cancer 

      Huynh, Bao-Mai (Master thesis, 2014)
      Prostatakreft er en av hovedårsakene til kreftrelaterte dødsfall i verden. Fremskritt i kunnskap om denne sykdommen kan bidra til å forbedre utfallet av sykdommen hos pasienter. Biomarkører kan forbedre detekteringen kreften ...
    • MR imaging and spectroscopy in prostate and colon cancer diagnostics 

      Selnæs, Kirsten Margrete (Doktoravhandlinger ved NTNU, 1503-8181; 2012:251, Doctoral thesis, 2012)
      Prostate and colorectal cancers are among the most common cancers in Norway and are also leading causes of cancer related deaths. In prostate cancer there are currently no accurate clinical methods to discriminate patients ...
    • Multi-Level Molecular Characterisation of Prostate Cancer 

      Sandsmark, Elise (Doctoral theses at NTNU;2017:174, Doctoral thesis, 2017)
      Prostate cancer is the most common malignancy in Norwegian men, and represents a substantial health burden. The disease is heterogeneous, ranging from slow growing and indolent, to very aggressive and lethal. One of the ...
    • Multiparametric Prostate MRI in Biopsy-Naïve Men: A Prospective Evaluation of Performance and Biopsy Strategies 

      Krüger-Stokke, Brage; Bertilsson, Helena; Langørgen, Sverre; Sjøbakk, Torill Eidhammer; Bathen, Tone Frost; Selnæs, Kirsten Margrete (Peer reviewed; Journal article, 2021)
      Objectives: This study aims to prospectively estimate the diagnostic performance of multiparametric prostate MRI (mpMRI) and compare the detection rates of prostate cancer using cognitive targeted transrectal ultrasound ...
    • Prediction of recurrence from metabolites and expression of TOP2A and EZH2 in prostate cancer patients treated with radiotherapy 

      Hansen, Ailin Falkmo; Høiem, Therese Stork; Selnæs, Kirsten Margrete; Bofin, Anna M.; Størkersen, Øystein; Bertilsson, Helena; Wright, Alan J.; Giskeødegård, Guro F.; Bathen, Tone Frost; Rye, Morten Beck; Tessem, May-Britt (Peer reviewed; Journal article, 2023)
      Background The dual upregulation of TOP2A and EZH2 gene expression has been proposed as a biomarker for recurrence in prostate cancer patients to be treated with radical prostatectomy. A low tissue level of the metabolite ...
    • Presence of TMPRSS2-ERG is associated with alterations of the metabolic profile in human prostate cancer 

      Hansen, Ailin Falkmo; Sandsmark, Elise; Rye, Morten Beck; Wright, Alan J; Bertilsson, Helena; Richardsen, Elin; Viset, Trond; Bofin, Anna M.; Angelsen, Anders; Selnæs, Kirsten Margrete; Bathen, Tone Frost; Tessem, May-Britt (Journal article; Peer reviewed, 2016)
      TMPRSS2-ERG has been proposed to be a prognostic marker for prostate cancer. The aim of this study was to identify changes in metabolism, genes and biochemical recurrence related to TMPRSS2-ERG by using an integrated ...