Browsing NTNU Open by Author "Sekurova, Olga N."
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Activation of chloramphenicol biosynthesis in Streptomyces venezuelae ATCC 10712 by ethanol shock: Insights from the promoter fusion studies
Sekurova, Olga N.; Zhang, Jianhai; Kristiansen, Kåre Andre; Zotchev, Sergey B (Peer reviewed; Journal article, 2016)Background Streptomyces venezuelae ATCC 10712 produces antibiotics chloramphenicol (Cml) and jadomycin (Jad) in response to nutrient limitation and ethanol shock (ES), respectively. Biosynthesis of Cml and Jad was shown ... -
An orthogonal system for heterologous expression of actinobacterial lasso peptides in Streptomyces hosts
Mevaere, Jimmy; Goulard, Christophe; Schneider, Olha; Sekurova, Olga N.; Ma, Haiyan; Zirah, Severine; Afonso, Carlos; Rebuffat, Sylvie; Zotchev, Sergey B; Li, Yanyan (Journal article; Peer reviewed, 2018)Lasso peptides are ribosomally synthesized and post-translationally modified peptides produced by bacteria. They are characterized by an unusual lariat-knot structure. Targeted genome scanning revealed a wide diversity of ... -
Coupling of the engineered DNA “mutator” to a biosensor as a new paradigm for activation of silent biosynthetic gene clusters in Streptomyces
Sekurova, Olga N.; Sun, Yi-Qian; Zehl, Martin; Rückert, Christian; Stich, Anna; Busche, Tobias; Kalinowski, Jörn; Zotchev, Sergey B. (Journal article; Peer reviewed, 2021) -
Development of a Biosensor Concept to Detect the Production of Cluster-Specific Secondary Metabolites
Sun, Yi-Qian; Busche, Tobias; Rückert, Christian; Paulus, Constanze; Rebets, Yuriy; Novakova, Renata; Kalinowski, Jörn; Luzhetskyy, Andriy; Kormanec, Jan; Sekurova, Olga N.; Zotchev, Sergey B. (Journal article; Peer reviewed, 2017)Genome mining of actinomycete bacteria aims at the discovery of novel bioactive secondary metabolites that can be developed into drugs. A new repressor-based biosensor to detect activated secondary metabolite biosynthesis ...