Blar i NTNU Open på forfatter "Samdal, Helle"
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Basal level of autophagy and MAP1LC3B-II as potential biomarkers for DHA-induced cytotoxicity in colorectal cancer cells
Samdal, Helle; Sandmoe, Malin Alise; Olsen, Lene Christin; Jarallah, Elaf Ali Hadi; Høiem, Therese Stork; Schønberg, Svanhild Margrethe Arentz; Pettersen, Caroline Hild (Journal article, 2018)The omega‐3 fatty acid docosahexaenoic acid (DHA) is known as an anticancer agent. Colorectal cancer (CRC) cells exhibit different sensitivity toward DHA, but the mechanisms involved are still unclear. Gene expression ... -
DHA-induced stress response in human colon cancer cells - Focus on oxidative stress and autophagy
Pettersen, Kristine; Monsen, Vivi Anita Talstad; Pettersen, Caroline Hild; Overland, Hilde Bremseth; Pettersen, Grete Klippenvåg; Samdal, Helle; Tesfahun, Almaz Nigatu; Lundemo, Anne Gøril; Bjørkøy, Geir; Schønberg, Svanhild Margrethe Arentz (Journal article; Peer reviewed, 2016)Polyunsaturated fatty acids (PUFAs) are important constituents of the diet and health benefits of omega-3/n−3 PUFAs, especially eicosapentaenoic acid (EPA, 20:5 n−3) and docosahexaenoic acid (DHA, 22:6 n−3) have been well ... -
DHA-induced stress response in human colon cancer cells - Focus on oxidative stress and autophagy
Pettersen, Kristine; Monsen, Vivi Anita Talstad; Pettersen, Caroline Hild; Overland, Hilde Bremseth; Pettersen, Grete Klippenvåg; Samdal, Helle; Tesfahun, Almaz Nigatu; Lundemo, Anne Gøril; Bjørkøy, Geir; Schønberg, Svanhild Margrethe Arentz (Journal article; Peer reviewed, 2016) -
Effect of DHA on growth of two human colon cancer cell lines - the role of ER stress and unfolded protein response
Samdal, Helle (Master thesis, 2014)Docosahexaenoic acid (DHA; 22:6n-3) is an essential omega-3 polyunsaturated fatty acid important to human health. DHA has been shown to have anticancer properties by reducing cancer cell proliferation, inducing apoptosis ... -
Establishment of a patient-derived xenograft model of colorectal cancer in CIEA NOG mice and exploring smartfish liquid diet as a source of omega-3 fatty acids
Samdal, Helle; Olsen, Lene Christin; Grøn, Knut Sverre; Røyset, Elin Synnøve; Høiem, Therese Stork; Nervik, Ingunn; Sætrom, Pål; Wibe, Arne; Schønberg, Svanhild Margrethe Arentz; Pettersen, Caroline Hild (Peer reviewed; Journal article, 2021)Cancer patient-derived xenografts (PDXs) better preserve tumor characteristics and microenvironment than traditional cancer cell line derived xenografts and are becoming a valuable model in translational cancer research ... -
Identification and characterization of long noncoding RNAs involved in the cell cycle
Samdal, Helle (Doctoral theses at NTNU;2021:234, Doctoral thesis, 2021)Lange ikke-kodende RNA involvert i cellesyklus For å produsere nye celler må kroppens celler dele seg til to identiske kopier i en prosess som kalles cellesyklus. Dette er en nøye kontrollert prosess for å sikre at ... -
Joint changes in RNA, RNA polymerase II, and promoter activity through the cell cycle identify non-coding RNAs involved in proliferation
Hegre, Siv Anita; Samdal, Helle; Klima, Antonin; Stovner, Endre Bakken; Nørsett, Kristin Gabestad; Liabakk, Nina-Beate; Olsen, Lene Christin; Chawla, Konika; Aas, Per Arne; Sætrom, Pål (Peer reviewed; Journal article, 2021)Proper regulation of the cell cycle is necessary for normal growth and development of all organisms. Conversely, altered cell cycle regulation often underlies proliferative diseases such as cancer. Long non-coding RNAs ...