Browsing NTNU Open by Author "Sætra, Ragnhild Sofie Ragnhildstveit"

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    • Glycine inhibits NINJ1 membrane clustering to suppress plasma membrane rupture in cell death 

      Borges, Jazlyn P.; Sætra, Ragnhild Sofie Ragnhildstveit; Volchuk, Allen; Bugge, Marit; Devant, Pascal; Sporsheim, Bjørnar; Kilburn, Bridget R.; Evavold, Charles L.; Kagan, Jonathan C.; Goldenberg, Neil M.; Flo, Trude Helen; Steinberg, Benjamin Ethan (Peer reviewed; Journal article, 2022)
      First recognized more than 30 years ago, glycine protects cells against rupture from diverse types of injury. This robust and widely observed effect has been speculated to target a late downstream process common to multiple ...

    • Membrane damage and inflammasome activation during Mtb infection 

      Sætra, Ragnhild Sofie Ragnhildstveit (Master thesis, 2019)
      Tuberkulose, som forårsakes av Mycobacterium tuberculosis (Mtb), er et globalt helseproblem, og økt forståelse av de molekylære mekanismene bak Mtb-infeksjon er viktig. På enkeltcellenivå kan Mtb-infeksjon føre til aktivering ...

    • Plasma membrane damage causes NLRP3 activation and pyroptosis during Mycobacterium tuberculosis infection 

      Beckwith, Kai Sandvold; Beckwith, Marianne Sandvold; Ullmann, Sindre; Sætra, Ragnhild Sofie Ragnhildstveit; Kim, Haelin; Marstad, Anne; Åsberg, Signe Elisabeth; Strand, Trine Aakvik; Haug, Markus; Niederweis, Michael; Stenmark, Harald Alfred; Flo, Trude Helen (Peer reviewed; Journal article, 2020)
      Mycobacterium tuberculosis is a global health problem in part as a result of extensive cytotoxicity caused by the infection. Here, we show how M. tuberculosis causes caspase-1/NLRP3/gasdermin D-mediated pyroptosis of human ...