Browsing NTNU Open by Author "Ryeng, Einar"
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Analysis of Microarray Data Using Inductive Logic Programming and Ontological Background Information
Ryeng, Einar (Doktoravhandlinger ved NTNU, 1503-8181; 2010:46, Doctoral thesis, 2010)The use of formal logic in chemometric analysis has been sparse. However, there are some problems which are well suited for analysis with inductive logic programming (ILP), a class of machine learning methods based on ... -
Computationally efficient familywise error rate control in genome‐wide association studies using score tests for generalized linear models
Halle, Kari Krizak; Bakke, Øyvind; Djurovic, Srdjan; Bye, Anja; Ryeng, Einar; Wisløff, Ulrik; Andreassen, Ole Andreas; Langaas, Mette (Peer reviewed; Journal article, 2020)In genetic association studies, detecting phenotype–genotype association is a primary goal. We assume that the relationship between the data—phenotype, genetic markers and environmental covariates—can be modeled by a ... -
Gene expression differences between PAXgene and Tempus blood RNA tubes are highly reproducible between independent samples and biobanks
Skogholt, Anne Heidi; Ryeng, Einar; Erlandsen, Sten Even; Skorpen, Frank; Arentz Schønberg, Svanhild Margrethe; Sætrom, Pål (Journal article; Peer reviewed, 2017)Background Gene expression profiling from blood is sensitive to technology choices. For example, the main blood RNA collection systems—the PAXgene and Tempus tubes—differently influence RNA expression signatures. The aim ... -
Identification of novel genetic variants associated with cardiorespiratory fitness
Bye, Anja; Klevjer, Marie; Ryeng, Einar; Silva, Gustavo Jose Justo; Moreira, Jose Bianco Nascimento; Stensvold, Dorthe; Wisløff, Ulrik (Peer reviewed; Journal article, 2020)Introduction Low maximal oxygen uptake (VO2max) is a strong and independent risk factor for all-cause and cardiovascular disease (CVD) mortality. For other CVD risk factors, numerous genetic association studies have been ... -
Powerful extreme phenotype sampling designs and score tests for genetic association studies
Bjørnland, Thea; Bye, Anja; Ryeng, Einar; Wisløff, Ulrik; Langaas, Mette (Journal article; Peer reviewed, 2018)We consider cross‐sectional genetic association studies (common and rare variants) where non‐genetic information is available or feasible to obtain for N individuals, but where it is infeasible to genotype all N individuals. ... -
The eGenVar data management system-cataloguing and sharing sensitive data and metadata for the life sciences
Razick, Sabry; Mocnik, Rok; Thomas, Laurent; Ryeng, Einar; Drabløs, Finn; Sætrom, Pål (Journal article; Peer reviewed, 2014)Systematic data management and controlled data sharing aim at increasing reproducibility, reducing redundancy in work, and providing a way to efficiently locate complementing or contradicting information. One method of ... -
The PBMC transcriptome profile after intake of oxidized versus high-quality fish oil: an explorative study in healthy subjects
Myhrstad, Mari; Ottestad, Inger; Günther, Clara-Cecilie; Ryeng, Einar; Holden, Marit; Nilsson, Astrid; Brønner, Kirsti Wettre; Kohler, Achim; Borge, Grethe Iren Andersen; Holven, Kirsten Bjørklund; Ulven, Stine Marie (Journal article; Peer reviewed, 2016)Background: Marine long-chain polyunsaturated fatty acids are susceptible to oxidation, generating a range of different oxidation products with suggested negative health effects. The aim of the present study was to utilize ...