Blar i NTNU Open på forfatter "Rolim, Natale Pinheiro Lage"
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Aerobic exercise training rescues cardiac protein quality control and blunts endoplasmic reticulum stress in heart failure rats
Bozi, Luiz H.M.; Jannig, Paulo R; Rolim, Natale Pinheiro Lage; Voltarelli, Vanessa; Dourado, Paulo MM; Wisløff, Ulrik; Brum, Patricia C. (Peer reviewed; Journal article, 2016)Cardiac endoplasmic reticulum (ER) stress through accumulation of misfolded proteins plays a pivotal role in cardiovascular diseases. In an attempt to reestablish ER homoeostasis, the unfolded protein response (UPR) is ... -
Atrial Myocyte Function and Ca2+ Handling Is Associated with Inborn Aerobic Capacity
Johnsen, Anne Berit; Rolim, Natale Pinheiro Lage; Stølen, Tomas; Alves, Marcia; Sousa, Mirta; Slupphaug, Geir; Britton, Steven L; Koch, Lauren G; Smith, Godfrey L; Wisløff, Ulrik; Høydal, Morten Andre (Peer reviewed; Journal article, 2013-10-16)Background: Although high aerobic capacity is associated with effective cardiac function, the effect of aerobic capacity on atrial function, especially in terms of cellular mechanisms, is not known. We aimed to investigate ... -
Circulating microRNAs May Serve as Biomarkers for Hypertensive Emergency End-Organ Injuries and Address Underlying Pathways in an Animal Model
Langlo, Knut Asbjørn Rise; Silva, Gustavo Jose Justo; Overrein, Tina Syvertsen; Adams, Volker; Wisløff, Ulrik; Dalen, Håvard; Rolim, Natale Pinheiro Lage; Hallan, Stein (Journal article; Peer reviewed, 2021)There is an incomplete understanding of the underlying pathophysiology in hypertensive emergencies, where severely elevated blood pressure causes acute end-organ injuries, as opposed to the long-term manifestations of ... -
Differential regulation of cysteine oxidative post-translational modifications in high and low aerobic capacity
Souza, Rodrigo W. A.; Alves, Christiano R. R.; Medeiros, Alessandra; Rolim, Natale Pinheiro Lage; Silva, Gustavo Jose Justo; Moreira, Jose Bianco Nascimento; Alves, Marcia Netto Magalhaes; Wohlwend, Martin; Gebriel, Mohammed; Hagen, Lars; Sharma, Animesh; Koch, Lauren G.; Britton, Steven L.; Slupphaug, Geir; Wisløff, Ulrik; Brum, Patricia C. (Journal article; Peer reviewed, 2018)Given the association between high aerobic capacity and the prevention of metabolic diseases, elucidating the mechanisms by which high aerobic capacity regulates whole-body metabolic homeostasis is a major research challenge. ... -
Effects of different exercise modalities on cardiac dysfunction in heart failure with preserved ejection fraction
Bode, David; Rolim, Natale Pinheiro Lage; Guthof, Tim; Hegemann, Niklas; Wakula, Paulina; Primessnig, Uwe; Berre, Anne Marie Ormbostad; Adams, Volker; Wisløff, Ulrik; Pieske, Burkert; Heinzel, Frank R.; Hohendanner, Felix (Peer reviewed; Journal article, 2021)Aims Heart failure with preserved ejection fraction (HFpEF) is an increasingly prevalent disease. Physical exercise has been shown to alter disease progression in HFpEF. We examined cardiomyocyte Ca2+ homeostasis and ... -
Exercise training reveals inflexibility of the diaphragm in an animal model of patients with obesity-driven heart failure with a preserved ejection fraction
Bowen, T Scott; Brauer, Dominic; Rolim, Natale Pinheiro Lage; Bækkerud, Fredrik Hjulstad; Kricke, Angela; Berre, Anne Marie Ormbostad; Fischer, Tina; Linke, Axel; Silva, Gustavo Jose Justo; Wisløff, Ulrik; Adams, Volker (Journal article; Peer reviewed, 2017)Background Respiratory muscle weakness contributes to exercise intolerance in patients with heart failure with a preserved ejection fraction (HFpEF)—a condition characterized by multiple comorbidities with few proven ... -
Integrative effect of carvedilol and aerobic exercise training therapies on improving cardiac contractility and remodeling in heart failure mice
Vanzelli, Andréa S.; Medeiros, Alessandra; Rolim, Natale Pinheiro Lage; Bartholomeu, Jan B.; Cunha, Telma F.; Bechara, Luiz G.; Gomes, Enéas R.M.; Mattos, Katt C.; Sirvente, Raquel; Salemi, Vera; Mady, Charles; Negrao, Carlos E.; Guatimosim, Silvia; Brum, Patricia C. (Journal article; Peer reviewed, 2013)The use of β-blockers is mandatory for counteracting heart failure (HF)-induced chronic sympathetic hyperactivity, cardiac dysfunction and remodeling. Importantly, aerobic exercise training, an efficient nonpharmacological ... -
Interval training improves right ventricular function in a mouse model of cigarette smoke induced-chronic obstructive pulmonary disease
Berre, Anne Marie Ormbostad (Master thesis, 2014)Patients with chronic obstructive pulmonary disease (COPD) have impaired lung function and exercise tolerance reducing their quality of life and increasing mortality. In recent years, there has been a growing consensus ... -
Muscular changes in animal models of heart failure with preserved ejection fraction: what comes closest to the patient?
Goto, Keita; Schauer, Antje; Augstein, Antje; Methawasin, Mei; Granzier, Henk; Halle, Martin; Craenenbroeck, Emeline M Van; Rolim, Natale Pinheiro Lage; Gielen, Stephan; Pieske, Burkert; Winzer, Ephraim B.; Linke, Axel; Adams, Volker (Peer reviewed; Journal article, 2021)Aims Heart failure with preserved ejection fraction (HFpEF) is associated with reduced exercise capacity elicited by skeletal muscle (SM) alterations. Up to now, no clear medical treatment advice for HFpEF is available. ... -
Myocardial Mitochondrial Metabolismin Diastolic Heart Failure: The Influence of Different Exercise Training Intensities
Gusky, Till (Master thesis, 2014)Background – Diastolic heart failure (DHF) has a growing prevalence and current treatment options have not improved this prognosis. To better understand DHF, this study, as part of a multicenter study denominated OptimEx, ... -
Optimizing Exercise Training in Prevention of Heart Failure with Preserved Ejection Fraction: Cardio-renal Function and Survival in Dahl salt-sensitive Animal Model
Lesko, Paulina (Master thesis, 2014)Heart failure with preserved ejection fraction (HFPEF) is the only cardiovascular disease with an increasing incidence and prevalence. Complex pa ... -
Skeletal Muscle Alterations Are Exacerbated in Heart Failure With Reduced Compared With Preserved Ejection Fraction: Mediated by Circulating Cytokines?
Rolim, Natale Pinheiro Lage; Werner, Sarah; Hoshi, Tomoya; Fischer, Tina; Wisloff, Ulrik; Halle, Martin; Adams, Volker; Seiler, M; Linke, Axel; Bowen, Scott; Dieterlen, Maja-Theresa; Schuler, Gerhard; Mangner, Norman (Journal article; Peer reviewed, 2016)BACKGROUND: A greater understanding of the different underlying mechanisms between patients with heart failure with reduced (HFrEF) and with preserved (HFpEF) ejection fraction is urgently needed to better direct future ... -
The role of high intensity interval training on endoplasmic reticulum stress in heart failure with preserved ejection fraction
Yang, Xiaojuan (Master thesis, 2014)Heart failure with preserved ejection fraction (HFpEF) is a condition that accounts for approximately 50 % of HF cases with the prevalence increased with advancing age. As of now, no effective treatment is available ...