• 18F-FACBC PET/MRI in diagnostic assessment and neurosurgery of gliomas 

      Karlberg, Anna Maria; Berntsen, Erik Magnus; Johansen, Håkon; Skjulsvik, Anne Jarstein; Reinertsen, Ingerid; Hong, Yan Dai; Xiao, Yiming; Rivaz, Hassan; Borghammer, Per; Solheim, Ole; Eikenes, Live (Journal article; Peer reviewed, 2019)
      Purpose This pilot study aimed to evaluate the amino acid tracer 18F-FACBC with simultaneous PET/MRI in diagnostic assessment and neurosurgery of gliomas. Materials and Methods Eleven patients with suspected primary or ...
    • Automatic Intraoperative Correction of Brain Shift for Accurate Neuronavigation 

      Iversen, Daniel Høyer; Wein, Wolfgang; Lindseth, Frank; Unsgård, Geirmund; Reinertsen, Ingerid (Journal article; Peer reviewed, 2018)
      Background Unreliable neuronavigation owing to inaccurate patient-to-image registration and brain shift is a major problem in conventional magnetic resonance imaging–guided neurosurgery. We performed a prospective ...
    • Automatic intraoperative estimation of blood flow direction during neurosurgical interventions 

      Iversen, Daniel Høyer; Løvstakken, Lasse; Unsgård, Geirmund; Reinertsen, Ingerid (Journal article; Peer reviewed, 2018)
      Purpose In neurosurgery, reliable information about blood vessel anatomy and flow direction is important to identify, characterize, and avoid damage to the vasculature. Due to ultrasound Doppler angle dependencies and the ...
    • Brain atlas for assessing the impact of tumor location on perioperative quality of life in patients with high-grade glioma: A prospective population-based cohort study 

      Sagberg, Lisa Millgård; Iversen, Daniel Høyer; Fyllingen, Even Hovig; Jakola, Asgeir Store; Reinertsen, Ingerid; Solheim, Ole (Journal article; Peer reviewed, 2019)
      Background Tumor location is important for surgical decision making. Particular attention is paid to regions that contain sensorimotor and language functions, but it is unknown if these are the most important regions from ...
    • Glioblastoma Segmentation: Comparison of Three Different Software Packages 

      Fyllingen, Even Hovig; Stensjøen, Anne Line; Berntsen, Erik Magnus; Reinertsen, Ingerid; Solheim, Ole (Journal article; Peer reviewed, 2016)
      To facilitate a more widespread use of volumetric tumor segmentation in clinical studies, there is an urgent need for reliable, user-friendly segmentation software. The aim of this study was therefore to compare three ...
    • Intraoperative 3D ultrasound-guided resection of diffuse low-grade gliomas: radiological and clinical results. 

      Bø, Hans Kristian; Solheim, Ole; Kvistad, Kjell Arne; Berntsen, Erik Magnus; Torp, Sverre Helge; Skjulsvik, Anne Jarstein; Reinertsen, Ingerid; Iversen, Daniel Høyer; Unsgård, Geirmund; Jakola, Asgeir S (Peer reviewed; Journal article, 2019)
      OBJECTIVE Extent of resection (EOR) and residual tumor volume are linked to prognosis in low-grade glioma (LGG) and there are various methods for facilitating safe maximal resection in such patients. In this prospective ...
    • Multimodal 18F-Fluciclovine PET/MRI and Ultrasound-Guided Neurosurgery of an Anaplastic Oligodendroglioma 

      Karlberg, Anna Maria; Berntsen, Erik Magnus; Johansen, Håkon; Myrthue, Mariane Olesen; Skjulsvik, Anne Jarstein; Reinertsen, Ingerid; Esmaeili, Morteza; Dai, Hong Yan; Xiao, Yiming; Rivaz, Hassan; Borghammer, Per; Solheim, Ole; Eikenes, Live (Journal article; Peer reviewed, 2017)
      Background Structural magnetic resonance imaging (MRI) and histopathologic tissue sampling are routinely performed as part of the diagnostic workup for patients with glioma. Because of the heterogeneous nature of gliomas, ...
    • Nonlinear deformation of tractography in ultrasound-guided low-grade gliomas resection 

      Xiao, Yiming; Eikenes, Live; Reinertsen, Ingerid; Rivaz, Hassan (Journal article; Peer reviewed, 2018)
      Purpose In brain tumor surgeries, maximum removal of cancerous tissue without compromising normal brain functions can improve the patient’s survival rate and therapeutic benefits. To achieve this, diffusion MRI and ...
    • Quantitative texture analysis in the prediction of IDH status in low-grade gliomas 

      Jakola, Asgeir Store; Zang, YH; Skjulsvik, Anne Jarstein; Solheim, Ole; Bø, Hans Kristian; Berntsen, Erik Magnus; Reinertsen, Ingerid; Gulati, Sasha; Förander, Petter; Brismar, Torkel B. (Journal article; Peer reviewed, 2017)
      Objectives Molecular markers provide valuable information about treatment response and prognosis in patients with low-grade gliomas (LGG). In order to make this important information available prior to surgery the aim of ...
    • Registration of MR to Percutaneous Ultrasound of the Spine for Image-Guided Surgery 

      Bø, Lars Eirik; Palomar, Rafael; Selbekk, Tormod; Reinertsen, Ingerid (Chapter, 2014)
      One of the main limitations of today’s navigation systems for spine surgery is that they often are not available until after the bone surface has been exposed. Also, they lack the capability of soft tissue imaging, both ...
    • Skull stripping MRI images of the brain using deep learning 

      Eide, Øystein Aas (Master thesis, 2018)
      Skull stripping is the task of finding pixels or voxels that establishes where the brain is in amedical image. It is an important step for many medical applications that analysis the brain.Today manual skull stripping is ...
    • Spatial distribution of malignant transformation in patients with low-grade glioma 

      Jakola, Asgeir S; Bouget, David Nicolas Jean-Marie; Reinertsen, Ingerid; Skjulsvik, Anne Jarstein; Sagberg, Lisa Millgård; Bø, Hans Kristian; Gulati, Sasha; Sjåvik, Kristin; Solheim, Ole (Journal article; Peer reviewed, 2020)
      Background Malignant transformation represents the natural evolution of diffuse low-grade gliomas (LGG). This is a catastrophic event, causing neurocognitive symptoms, intensified treatment and premature death. However, ...
    • The diagnostic properties of intraoperative ultrasound in glioma surgery and factors associated with gross total tumor resection 

      Munkvold, Bodil Karoline Ravn; Jakola, Asgeir Store; Reinertsen, Ingerid; Sagberg, Lisa Millgård; Unsgård, Geirmund; Solheim, Ole (Journal article; Peer reviewed, 2018)
      Objective In glioma operations, we sought to analyze sensitivity, specificity, and predictive values of intraoperative 3-dimensional ultrasound (US) for detecting residual tumor compared with early postoperative magnetic ...
    • The Direction of Tumour Growth in Glioblastoma Patients 

      Esmaeili, Morteza; Stensjøen, Anne Line; Berntsen, Erik Magnus; Solheim, Ole; Reinertsen, Ingerid (Journal article; Peer reviewed, 2018)
      Generating MR-derived growth pattern models for glioblastoma multiforme (GBM) has been an attractive approach in neuro-oncology, suggesting a distinct pattern of lesion spread with a tendency in growing along the white ...
    • Ultrasound in image-guided spine surgery: Enabling technologies and first steps 

      Bø, Lars Eirik (Doctoral theses at NTNU;2018:257, Doctoral thesis, 2018)
      Most people experience back pain at some point in their life. While most of these conditions are treated nonoperatively, surgical treatment has been shown to be both effective and cost effective compared to nonoperative ...
    • Using the CustusX toolkit to create an image guided bronchoscopy application: Fraxinus 

      Bakeng, Janne Beate Lervik; Hofstad, Erlend Fagertun; Solberg, Ole Vegard; Eiesland, Jon Wostryck; Tangen, Geir Arne; Amundsen, Tore; Langø, Thomas; Reinertsen, Ingerid; Selbekk, Tormod; Leira, Håkon Olav (Journal article; Peer reviewed, 2019)
      Purpose The aim of this paper is to show how a specialized planning and guidance application called Fraxinus, can be built on top of the CustusX platform (www.custusx.org), which is an open source image-guided intervention ...
    • Volumetric segmentations for quantitative radiological evaluations in patients with high-grade glioma 

      Fyllingen, Even Hovig (Doctoral theses at NTNU;2020:130, Doctoral thesis, 2020)
      Sammendrag på norsk Volumsegmentering for kvantitative radiologiske vurderinger hos pasienter med høygradig gliom Diffuse høygradige gliomer er ondartede primære hjernesvulster. Glioblastom er den vanligste og mest ...