Browsing NTNU Open by Author "Reiersølmoen, Ann Christin"

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    • Development of Chiral Gold(III)-complexes and Studies of Their Catalytic Activity 

      Østrem, Elise (Master thesis, 2018)
      The purpose of this master project was to synthesise chiral ligands and coordinate these to gold(III), thereby developing novel chiral gold(III)-complexes. These complexes were then used as gold-catalysts in cyclopropanation ...

    • Gold(III) Complexes: Ligand Design and Catalytic Properties 

      Reiersølmoen, Ann Christin (Doctoral theses at NTNU;2020:264, Doctoral thesis, 2020)
      Gold catalysis has become one of the fastest growing fields in organic chemistry, providing new transformations and offering excellent chemoselectivities at mild reaction conditions. So far, the main focus within Au(III) ...

    • Gold(III)‐Catalysed cis‐to‐trans Cyclopropyl Isomerization 

      Reiersølmoen, Ann Christin; Østrem, Elise; Fiksdahl, Anne (Journal article; Peer reviewed, 2018)
      Novel chiral gold(III) complexes, based on bisoxazoline (BOX) and 2‐pyridyl‐(–)menthol ligands, were prepared and characterised (X‐ray), and their catalytic properties in cyclopropanation reactions of propargyl esters with ...

    • Identification of fused pyrimidines as interleukin 17 secretion inhibitors 

      Reiersølmoen, Ann Christin; Han, Jin; Sundby, Eirik; Hoff, Bård Helge (Journal article; Peer reviewed, 2018)
      Inhibiting the interleukin 17 pathway is of interest in a number of autoimmune diseases. Herein, 42 fused pyrimidines have been evaluated as interleukin 17 secretion inhibitors using a phenotypic assay with peripheral ...

    • Potent and selective EGFR inhibitors based on 5-aryl-7H-pyrrolopyrimidin-4-amines 

      Reiersølmoen, Ann Christin; Aarhus, Thomas Ihle; Eckelt, Sarah; Nørsett, Kristin Gabestad; Sundby, Eirik; Hoff, Bård Helge (Journal article; Peer reviewed, 2019)
      The epidermal growth factor receptor represents an important target in cancer therapy, and low molecular weight inhibitors based on quinazolines have reached the marked. Herein we report on a new scaffold, 5-aryl-7H-pyrr ...

    • Synthesis of 5-Aryl-Pyrrolo[2,3-d]pyrimidines and Their Bioactivity 

      Reiersølmoen, Ann Christin (Master thesis, 2016)
      The epidermal growth factor receptor tyrosine kinase is one of the more important targets in targeted cancer therapy. However, on prolonged administration of EGFR inhibitors, resistance emerge, which in 50% of the cases ...