• PYY plays a key role in the resolution of diabetes following bariatric surgery in humans 

      Sam D, Stephen; Claudia, Guida; Watson, Michael; Dempster, Niall; Larraufie, Pierre; Marjot, Thomas; Cargill, Tamsin; Rickers, Lisa; Pavlides, Michael; Tomlinson, Jeremy; Cobbold, Jeremy F.L.; Zhao, Chun-Mei; Chen, Duan; Gribble, Fiona M; Reimann, Frank; Gillies, Richard; Sgromo, Bruno; Rorsman, Patrik; Ryan, John D; Ramracheya, Reshma D. (Journal article; Peer reviewed, 2019)
      Background Bariatric surgery leads to early and long-lasting remission of type 2 diabetes (T2D). However, the mechanisms behind this phenomenon remain unclear. Among several factors, gut hormones are thought to be crucial ...
    • PYY-Dependent Restoration of Impaired Insulin and Glucagon Secretion in Type 2 Diabetes following Roux-En-Y Gastric Bypass Surgery 

      Ramracheya, Reshma D.; McCulloch, Laura J.; Clark, Anne; Wiggins, David; Johannessen, Helene; Olsen, Magnus Kringstad; Cai, Xing; Zhao, Chun-Mei; Chen, Duan; Rorsman, Patrik (Journal article; Peer reviewed, 2016)
      Roux-en-Y gastric bypass (RYGB) is a weight-reduction procedure resulting in rapid resolution of type 2 diabetes (T2D). The role of pancreatic islet function in this restoration of normoglycemia has not been fully elucidated. ...