Browsing NTNU Open by Author "Røyset, Elin Synnøve"
Now showing items 1-11 of 11
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Code-Free Development and Deployment of Deep Segmentation Models for Digital Pathology
Pettersen, Henrik P Sahlin; Belevich, Ilya; Røyset, Elin Synnøve; Smistad, Erik; Simpson, Melanie Rae; Jokitalo, Eija; Reinertsen, Ingerid; Bakke, Ingunn; Pedersen, André (Peer reviewed; Journal article, 2022)Application of deep learning on histopathological whole slide images (WSIs) holds promise of improving diagnostic efficiency and reproducibility but is largely dependent on the ability to write computer code or purchase ... -
Deep learning-based image analysis reveals significant differences in the number and distribution of mucosal CD3 and γδ T cells between Crohn's disease and ulcerative colitis
Røyset, Elin Synnøve; Pettersen, Henrik Sahlin; Xu, Weili; Larbi, Anis; Sandvik, Arne Kristian; Steigen, Sonja Eriksson; Catalan-Serra, Ignacio; Bakke, Ingunn (Peer reviewed; Journal article, 2022)Colon mucosae of ulcerative colitis (UC) and Crohn's disease (CD) display differences in the number and distribution of immune cells that are difficult to assess by eye. Deep learning-based analysis on whole slide images ... -
Establishment of a patient-derived xenograft model of colorectal cancer in CIEA NOG mice and exploring smartfish liquid diet as a source of omega-3 fatty acids
Samdal, Helle; Olsen, Lene Christin; Grøn, Knut Sverre; Røyset, Elin Synnøve; Høiem, Therese Stork; Nervik, Ingunn; Sætrom, Pål; Wibe, Arne; Schønberg, Svanhild Margrethe Arentz; Pettersen, Caroline Hild (Peer reviewed; Journal article, 2021)Cancer patient-derived xenografts (PDXs) better preserve tumor characteristics and microenvironment than traditional cancer cell line derived xenografts and are becoming a valuable model in translational cancer research ... -
The ileal fungal microbiota is altered in Crohn's disease and is associated with the disease course
Olaisen, Maya; Richard, Mathias L.; Beisvag, Vidar; Granlund, Atle van Beelen; Røyset, Elin Synnøve; Rué, Olivier; Martinsen, Tom Christian; Sandvik, Arne Kristian; Sokol, Harry; Fossmark, Reidar (Peer reviewed; Journal article, 2022)Introduction: Fungal microbiota's involvement in the pathogenesis of Crohn's disease (CD) is incompletely understood. The terminal ileum is a predilection site both for primary involvement and recurrences of CD. We, ... -
Mucosal 5-aminosalicylic acid concentration, drug formulation and mucosal microbiome in patients with quiescent ulcerative colitis
Olaisen, Maya; Spigset, Olav; Flatberg, Arnar; Granlund, Atle van Beelen; Brede, wenche Rødseth; Albrektsen, Grethe; Røyset, Elin Synnøve; Gilde, Bodil; Sandvik, Arne Kristian; Martinsen, Tom Christian; Fossmark, Reidar (Journal article; Peer reviewed, 2019)Background 5‐aminosalicylic acid (5‐ASA) is the first‐line therapy for ulcerative colitis (UC). 5‐ASA acts locally in the colonic mucosa by numerous proposed mechanisms, and is metabolised by N‐acetyltransferase (NAT). ... -
Mucosal and faecal neutrophil gelatinase-associated lipocalin as potential biomarkers for collagenous colitis
Bakke, Ingunn; Walaas, Gunnar Andreas; Bruland, Torunn; Røyset, Elin Synnøve; Granlund, Atle van Beelen; Escudero-Hernandez, Celia; Thorsvik, Silje; Münch, Andreas; Sandvik, Arne Kristian; Østvik, Ann Elisabet (Peer reviewed; Journal article, 2021)Background Collagenous colitis (CC) is an inflammatory bowel disease where chronic diarrhoea is the main symptom. Diagnostic markers distinguishing between CC and other causes of chronic diarrhoea remain elusive. This study ... -
Profound gene expression changes in the epithelial monolayer of active ulcerative colitis and Crohn's disease
Sæterstad, Siri; Østvik, Ann Elisabet; Røyset, Elin Synnøve; Bakke, Ingunn; Sandvik, Arne Kristian; Granlund, Atle van Beelen (Peer reviewed; Journal article, 2022)In recent years it has become apparent that the epithelium is highly involved in inflammatory bowel disease (IBD) pathophysiology. The majority of gene expression studies of IBD are generated from heterogeneous biopsies, ... -
Response Evaluation after Neoadjuvant Chemotherapy for Resectable Gastric Cancer
Sandø-Klemmetvoll, Alina Desiree; Fougner, Reidun; Røyset, Elin Synnøve; Dai, Hong Yan; Grønbech, Jon Erik; Bringeland, Erling Audun (Peer reviewed; Journal article, 2023)Background: The method of response evaluation following neoadjuvant chemotherapy (NAC) in resectable gastric cancer has been widely debated. An essential prerequisite is the ability to stratify patients into subsets of ... -
Subtle protective roles of clusterin in gastric metaplasia after acute oxyntic atrophy
Vange, Pål; Bruland, Torunn; Munkvold, Bjørn; Røyset, Elin Synnøve; Gleave, Martin E.; Bakke, Ingunn (Journal article; Peer reviewed, 2018) -
The Norwegian PMS2 founder mutation c.989-1G>T shows high penetrance of microsatellite instable cancers with normal immunohistochemistry
Grindedal, Eli Marie; Aarset, Harald; Bjørnevoll, Inga; Røyset, Elin Synnøve; Mæhle, Lovise Olaug; Stormorken, Astrid T.; Heramb, Cecilie; Medvik, Heidi; Møller, Pål; Sjursen, Wenche (Journal article; Peer reviewed, 2014)Background Using immunohistochemistry (IHC) to select cases for mismatch repair (MMR) genetic testing, we failed to identify a large kindred with the deleterious PMS2 mutation c.989-1G > T. The purpose of the study was ... -
Ulcer-associated cell lineage expresses genes involved in regeneration and is hallmarked by high neutrophil gelatinase-associated lipocalin (NGAL) levels
Thorsvik, Silje; Granlund, Atle van Beelen; Svendsen, Tarjei Dahl; Bakke, Ingunn; Røyset, Elin Synnøve; Flo, Trude Helen; Damås, Jan Kristian; Østvik, Ann Elisabet; Bruland, Torunn; Sandvik, Arne Kristian (Peer reviewed; Journal article, 2019)Neutrophil gelatinase‐associated lipocalin (NGAL), also known as Lipocalin 2, is an antimicrobial protein, encoded by the gene LCN2, strongly upregulated in inflammatory bowel disease (IBD) and a promising biomarker for ...