Browsing NTNU Open by Author "Røe, Oluf Dimitri"
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A data driven approach reveals disease similarity on a molecular level
Lakiotaki, Kleanthi; Georgakopoulos, George; Castanas, Elias; Røe, Oluf Dimitri; Borboudakis, Giorgos; Tsamardinos, Ioannis (Journal article; Peer reviewed, 2019)Could there be unexpected similarities between different studies, diseases, or treatments, on a molecular level due to common biological mechanisms involved? To answer this question, we develop a method for computing ... -
A Functional Polymorphism C-509T in TGFβ-1 Promoter Contributes to Susceptibility and Prognosis of Lone Atrial Fibrillation in Chinese Population
Cao, Hailong; Zhou, Qing; Lan, Rongfang; Røe, Oluf Dimitri; Chen, Xin; Chen, Yijiang; Wang, Dongjin (Journal article; Peer reviewed, 2014)Transforming growth factor-β1 (TGF-β1) is an important mediator of atrial fibrosis and atrial fibrillation (AF). But the involved genetic mechanism is unknown. Herein, the TGF-β1 C-509T polymorphism (rs1800469) was genotyped ... -
A Validated Clinical Risk Prediction Model for Lung Cancer in Smokers of All Ages and Exposure Types: A HUNT Study
Markaki, Maria Dorothea Haaberg; Tsamardinos, Ioannis; Langhammer, Arnulf; Lagani, Vincenzo; Hveem, Kristian; Røe, Oluf Dimitri (Journal article; Peer reviewed, 2018)Lung cancer causes >1·6 million deaths annually, with early diagnosis being paramount to effective treatment. Here we present a validated risk assessment model for lung cancer screening. The prospective HUNT2 population ... -
A clinical prognostic scoring system for resectable gastric cancer to predict survival and benefit from paclitaxel- or oxaliplatin-based adjuvant chemotherapy
Qian, Jing; Qian, Yingying; Wang, Jian; Gu, Bing; Pei, Dong; He, Shaohua; Zhu, Fang; Røe, Oluf Dimitri; Xu, Jin; Liu, Lianke; Gu, Yanhong; Guo, Renhua; Yin, Yongmei; Shu, Yongqian; Chen, Xiaofeng (Peer reviewed; Journal article, 2016)Background: Gastrectomy with D2 lymphadenectomy is a standard procedure of curative resection for gastric cancer (GC). The aim of this study was to develop a simple and reliable prognostic scoring system for GC treated ... -
Excerpts from the 1st international NTNU symposium on current and future clinical biomarkers of cancer: innovation and implementation, June 16th and 17th 2016, Trondheim, Norway
Robles, Ana I.; Olsen, Karina Standahl; Tsui, Dana W.T.; Georgoulias, Vassilis; Creaney, Jenette; Dobra, Katalin; Vyberg, Mogens; Minato, Nagahiro; Anders, Robert A.; Børresen-Dale, Anne-Lise; Zhou, Jianwei; Sætrom, Pål; Nielsen, Boye Schnack; Kirschner, Michaela B.; Krokan, Hans Einar; Papadimitrakopoulou, Vassiliki; Tsamardinos, Ioannis; Røe, Oluf Dimitri (Journal article; Peer reviewed, 2016)The goal of biomarker research is to identify clinically valid markers. Despite decades of research there has been disappointingly few molecules or techniques that are in use today. The “1st International NTNU Symposium ... -
Gefitinib or Erlotinib as Maintenance Therapy in Patients with Advanced Stage Non-Small Cell Lung Cancer: A Systematic Review
Chen, Xiaofeng; Liu, YQ; Røe, Oluf Dimitri; Qian, YY; Guo, RH; Zhu, LJ; Yin, YM; Shu, YQ (Journal article; Peer reviewed, 2013)Background: Epidermal growth factor receptor (EGFR) tyrosine kinase inhibitors (TKI), gefitinib and erlotinib have been tested as maintenance therapy in patients with advanced non-small-cell lung cancer (NSCLC). The ... -
Genome-Wide Profile of Pleural Mesothelioma versus Parietal and Visceral Pleura: The emerging Gene Portrait of the Mesothelioma Phenotype
Røe, Oluf Dimitri; Anderssen, Endre; Helge, Eli; Pettersen, Caroline Hild; Olsen, Karina Standahl; Sandeck, H; Haaverstad, Rune; Lundgren, Steinar; Larsson, Erik (Journal article; Peer reviewed, 2009) -
Hidden treasures in "ancient" microarrays: Gene expression portrays biology and potential resistance pathways of major lung cancer subtypes and normal tissue
Kerkentzes, Konstantinos; Lagani, Vincenzo; Tsamardinos, Ioannis; Vyberg, Mogens; Røe, Oluf Dimitri (Journal article; Peer reviewed, 2014)Objective: Novel statistical methods and increasingly more accurate gene annotations can transform “old” biological data into a renewed source of knowledge with potential clinical relevance. Here, we provide an in silico ... -
Icotinib is an active treatment of non-small-cell lung cancer: A retrospective study
Chen, X; Zhu, Q; Liu, Y; Liu, P; Yin, Y; Guo, R; Lu, K; Gu, Y; Liu, L; Wang, J; Wang, Z; Røe, Oluf Dimitri; Shu, Y; Zhu, L (Journal article; Peer reviewed, 2014)Background Icotinib hydrochloride is a novel epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor (TKI) with preclinical and clinical activity in non-small cell lung cancer (NSCLC). This retrospective ... -
JWA regulates TRAIL-induced apoptosis via MARCH8-mediated DR4 ubiquitination in cisplatin-resistant gastric cancer cells
Wang, Q; Chen, Q; Zhu, L; Chen, M; Xu, W; Panday, S; Wang, Z; Li, A; Røe, Oluf Dimitri; Chen, R; Wang, S; Zhang, R; Zhou, J (Journal article; Peer reviewed, 2017)Platinum chemotherapeutics are widely used to treat solid malignant tumors, including gastric cancer (GC). Drug resistance to platinum compounds may result in cancer relapse and decreased survival. The identification and ... -
JWA reverses cisplatin resistance via the CK2-XRCC1 pathway in human gastric cancer cells
Xu, W; Chen, Q; Wang, Q; Sun, Y; Wang, S; Li, A; Xu, S; Røe, Oluf Dimitri; Wang, R; Zhang, R.; Yang, L; Zhou, J. (Journal article; Peer reviewed, 2014)Gastric cancer is the third most common malignancy in China, with a median 5-year survival of only 20%. Cisplatin has been used in first-line cancer treatment for several types of cancer including gastric cancer. However, ... -
Malignant Mesothelioma: Virus, Biomarkers and Genes- a Translational Approach
Røe, Oluf Dimitri (Doktoravhandlinger ved NTNU, 1503-8181; 2008:275, Doctoral thesis, 2008)Malignant mesothelioma is an asbestos-related, lethal treatment resistant tumour with increasing incidence worldwide. In four translational studies we have studied the pathogenesis of mesothelioma with regard to the SV40 ... -
Malignant Mesothelioma: Virus, Biomarkers and Genes- a Translational Approach
Røe, Oluf Dimitri (Doktoravhandlinger ved NTNU, 1503-8181; 2008:275, Doctoral thesis, 2008)Malignant mesothelioma is an asbestos-related, lethal treatment resistant tumour with increasing incidence worldwide. In four translational studies we have studied the pathogenesis of mesothelioma with regard to the SV40 ... -
Malignant pleural mesothelioma: History, controversy and future of a manmade epidemic
Røe, Oluf Dimitri; Stella, Giulia Maria (Journal article; Peer reviewed, 2015)Asbestos is the term for a family of naturally occurring minerals that have been used on a small scale since ancient times. Industrialisation demanded increased mining and refining in the 20th century, and in 1960, Wagner, ... -
MDM2 is a useful prognostic biomarker for resectable gastric cancer
Ye, Yang; Li, Xuan; Yang, Jiangjing; Miao, Shuhan; Wang, Shouyu; Chen, Yansu; Xia, Xiaowei; Wu, Xuming; Zhang, Jianbing; Zhou, Yan; He, Song; Tan, YongFei; Qiang, FuLin; Li, Gang; Røe, Oluf Dimitri; Zhou, Jianwei (Journal article; Peer reviewed, 2013)Expression of MDM2 protein appears to be increased in malignancy and correlated to prognosis of tumors, but its role in gastric cancer remains controversial. Our recent investigations indicated that JWA was a novel candidate ... -
Molecular Resistance Fingerprint of Pemetrexed and Platinum in a Long-Term Survivor of Mesothelioma
Røe, Oluf Dimitri; Szulkin, Adam; Anderssen, Endre; Flatberg, Arnar; Sandeck, Helmut; Amundsen, Tore; Erlandsen, Sten Even; Dobra, Katalin; Sundstrøm, Stein Harald (Journal article; Peer reviewed, 2012) -
Prognostic role of microscopically positive margins for primary gastrointestinal stromal tumors: a systematic review and meta-analysis
Zhi, Xiaofei; Jiang, Baofei; Yu, Junbo; Røe, Oluf Dimitri; Qin, Jun; Ni, Qingfeng; Sun, Luning; Xu, Meirong; Zhu, Jianwei; Ma, Lilin (Peer reviewed; Journal article, 2016)The impact and management of microscopically positive margins in gastrointestinal stromal tumors (GISTs) remain unclear. The aim of this study is to estimate the prognostic value of surgical margins for disease-free survival ... -
‘Reduced’ HUNT model outperforms NLST and NELSON study criteria in predicting lung cancer in the Danish screening trial
Røe, Oluf Dimitri; Markaki, Maria; Tsamardinos, Ioannis; Lagani, Vincenzo; Nguyen, Olav Toai Duc; Pedersen, Jesper Holst; Saghir, Zaigham; Ashraf, Haseem (Journal article; Peer reviewed, 2019)Hypothesis We hypothesise that the validated HUNT Lung Cancer Risk Model would perform better than the NLST (USA) and the NELSON (Dutch‐Belgian) criteria in the Danish Lung Cancer Screening Trial (DLCST). Methods The ... -
Synergistic Role between p53 and JWA: Prognostic and Predictive Biomarkers in Gastric Cancer
Liu, Xin; Wang, Shouyu; Xia, Xiaowei; Chen, Yansu; Zhou, Yan; Wu, Xuming; Zhang, Jianbing; He, Song; Tan, YongFei; Qiang, FuLin; Røe, Oluf Dimitri; Li, Gang; Zhou, Jianwei (Journal article; Peer reviewed, 2012)Expression of p53 appears to be correlated to prognosis in patients with malignancy, but its role in gastric carcinoma has remained controversial. Recently we reported that JWA, an ADP-ribosylation-like factor 6 interacting ... -
The associations of sitting time and physical activity on total and site-specific cancer incidence: Results from the HUNT study, Norway
Rangul, Vegar; Sund, Erik Reidar; Mork, Paul Jarle; Røe, Oluf Dimitri; Bauman, Adrian (Journal article; Peer reviewed, 2018)Background Sedentary behavior is thought to pose different risks to those attributable to physical inactivity. However, few studies have examined the association between physical activity and sitting time with cancer ...