Blar i NTNU Open på forfatter "Røe, Oluf Dimitri"
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A data driven approach reveals disease similarity on a molecular level
Lakiotaki, Kleanthi; Georgakopoulos, George; Castanas, Elias; Røe, Oluf Dimitri; Borboudakis, Giorgos; Tsamardinos, Ioannis (Journal article; Peer reviewed, 2019)Could there be unexpected similarities between different studies, diseases, or treatments, on a molecular level due to common biological mechanisms involved? To answer this question, we develop a method for computing ... -
A Functional Polymorphism C-509T in TGFβ-1 Promoter Contributes to Susceptibility and Prognosis of Lone Atrial Fibrillation in Chinese Population
Cao, Hailong; Zhou, Qing; Lan, Rongfang; Røe, Oluf Dimitri; Chen, Xin; Chen, Yijiang; Wang, Dongjin (Journal article; Peer reviewed, 2014)Transforming growth factor-β1 (TGF-β1) is an important mediator of atrial fibrosis and atrial fibrillation (AF). But the involved genetic mechanism is unknown. Herein, the TGF-β1 C-509T polymorphism (rs1800469) was genotyped ... -
A Validated Clinical Risk Prediction Model for Lung Cancer in Smokers of All Ages and Exposure Types: A HUNT Study
Markaki, Maria Dorothea Haaberg; Tsamardinos, Ioannis; Langhammer, Arnulf; Lagani, Vincenzo; Hveem, Kristian; Røe, Oluf Dimitri (Journal article; Peer reviewed, 2018)Lung cancer causes >1·6 million deaths annually, with early diagnosis being paramount to effective treatment. Here we present a validated risk assessment model for lung cancer screening. The prospective HUNT2 population ... -
A clinical prognostic scoring system for resectable gastric cancer to predict survival and benefit from paclitaxel- or oxaliplatin-based adjuvant chemotherapy
Qian, Jing; Qian, Yingying; Wang, Jian; Gu, Bing; Pei, Dong; He, Shaohua; Zhu, Fang; Røe, Oluf Dimitri; Xu, Jin; Liu, Lianke; Gu, Yanhong; Guo, Renhua; Yin, Yongmei; Shu, Yongqian; Chen, Xiaofeng (Peer reviewed; Journal article, 2016)Background: Gastrectomy with D2 lymphadenectomy is a standard procedure of curative resection for gastric cancer (GC). The aim of this study was to develop a simple and reliable prognostic scoring system for GC treated ... -
Excerpts from the 1st international NTNU symposium on current and future clinical biomarkers of cancer: innovation and implementation, June 16th and 17th 2016, Trondheim, Norway
Robles, Ana I.; Olsen, Karina Standahl; Tsui, Dana W.T.; Georgoulias, Vassilis; Creaney, Jenette; Dobra, Katalin; Vyberg, Mogens; Minato, Nagahiro; Anders, Robert A.; Børresen-Dale, Anne-Lise; Zhou, Jianwei; Sætrom, Pål; Nielsen, Boye Schnack; Kirschner, Michaela B.; Krokan, Hans Einar; Papadimitrakopoulou, Vassiliki; Tsamardinos, Ioannis; Røe, Oluf Dimitri (Journal article; Peer reviewed, 2016)The goal of biomarker research is to identify clinically valid markers. Despite decades of research there has been disappointingly few molecules or techniques that are in use today. The “1st International NTNU Symposium ... -
Fractional exhaled nitric oxide as a potential biomarker for radiation pneumonitis in patients with non-small cell lung cancer: A pilot study
Szejniuk, Weronika Maria; Nielsen, Martin Skovmos; Brønnum, Dorthe; Takacs-Szabo, Z; Weinreich, Ulla Møller; Pilegaard Thomsen, L; Bøgsted, Martin; Jensen, Ingelise; McCulloch, Tine; Falkmer, Ursula; Carl, Jesper; Røe, Oluf Dimitri (Peer reviewed; Journal article, 2019)Introduction The aim of the study was to investigate repetitive fractional exhaled nitric oxide (FeNO) measurements during high-dose radiation therapy (HDRT) and to evaluate the use of FeNO to predict symptomatic radiation ... -
Gefitinib or Erlotinib as Maintenance Therapy in Patients with Advanced Stage Non-Small Cell Lung Cancer: A Systematic Review
Chen, Xiaofeng; Liu, YQ; Røe, Oluf Dimitri; Qian, YY; Guo, RH; Zhu, LJ; Yin, YM; Shu, YQ (Journal article; Peer reviewed, 2013)Background: Epidermal growth factor receptor (EGFR) tyrosine kinase inhibitors (TKI), gefitinib and erlotinib have been tested as maintenance therapy in patients with advanced non-small-cell lung cancer (NSCLC). The ... -
Genome-Wide Profile of Pleural Mesothelioma versus Parietal and Visceral Pleura: The emerging Gene Portrait of the Mesothelioma Phenotype
Røe, Oluf Dimitri; Anderssen, Endre; Helge, Eli; Pettersen, Caroline Hild; Olsen, Karina Standahl; Sandeck, H; Haaverstad, Rune; Lundgren, Steinar; Larsson, Erik (Journal article; Peer reviewed, 2009) -
Hidden treasures in "ancient" microarrays: Gene expression portrays biology and potential resistance pathways of major lung cancer subtypes and normal tissue
Kerkentzes, Konstantinos; Lagani, Vincenzo; Tsamardinos, Ioannis; Vyberg, Mogens; Røe, Oluf Dimitri (Journal article; Peer reviewed, 2014)Objective: Novel statistical methods and increasingly more accurate gene annotations can transform “old” biological data into a renewed source of knowledge with potential clinical relevance. Here, we provide an in silico ... -
Icotinib is an active treatment of non-small-cell lung cancer: A retrospective study
Chen, X; Zhu, Q; Liu, Y; Liu, P; Yin, Y; Guo, R; Lu, K; Gu, Y; Liu, L; Wang, J; Wang, Z; Røe, Oluf Dimitri; Shu, Y; Zhu, L (Journal article; Peer reviewed, 2014)Background Icotinib hydrochloride is a novel epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor (TKI) with preclinical and clinical activity in non-small cell lung cancer (NSCLC). This retrospective ... -
Inherited Genetic Mutations and Polymorphisms in Malignant Mesothelioma: A Comprehensive Review
Panou, Vasiliki; Røe, Oluf Dimitri (Peer reviewed; Journal article, 2020)Malignant mesothelioma (MM) is mainly caused by air-born asbestos but genetic susceptibility is also suspected to be a risk factor. Recent studies suggest an increasing number of candidate genes that may predispose to MM ... -
JWA regulates TRAIL-induced apoptosis via MARCH8-mediated DR4 ubiquitination in cisplatin-resistant gastric cancer cells
Wang, Q; Chen, Q; Zhu, L; Chen, M; Xu, W; Panday, S; Wang, Z; Li, A; Røe, Oluf Dimitri; Chen, R; Wang, S; Zhang, R; Zhou, J (Journal article; Peer reviewed, 2017)Platinum chemotherapeutics are widely used to treat solid malignant tumors, including gastric cancer (GC). Drug resistance to platinum compounds may result in cancer relapse and decreased survival. The identification and ... -
JWA reverses cisplatin resistance via the CK2-XRCC1 pathway in human gastric cancer cells
Xu, W; Chen, Q; Wang, Q; Sun, Y; Wang, S; Li, A; Xu, S; Røe, Oluf Dimitri; Wang, R; Zhang, R.; Yang, L; Zhou, J. (Journal article; Peer reviewed, 2014)Gastric cancer is the third most common malignancy in China, with a median 5-year survival of only 20%. Cisplatin has been used in first-line cancer treatment for several types of cancer including gastric cancer. However, ... -
Malignant Mesothelioma: Virus, Biomarkers and Genes- a Translational Approach
Røe, Oluf Dimitri (Doktoravhandlinger ved NTNU, 1503-8181; 2008:275, Doctoral thesis, 2008)Malignant mesothelioma is an asbestos-related, lethal treatment resistant tumour with increasing incidence worldwide. In four translational studies we have studied the pathogenesis of mesothelioma with regard to the SV40 ... -
Malignant Mesothelioma: Virus, Biomarkers and Genes- a Translational Approach
Røe, Oluf Dimitri (Doktoravhandlinger ved NTNU, 1503-8181; 2008:275, Doctoral thesis, 2008)Malignant mesothelioma is an asbestos-related, lethal treatment resistant tumour with increasing incidence worldwide. In four translational studies we have studied the pathogenesis of mesothelioma with regard to the SV40 ... -
Malignant pleural mesothelioma: History, controversy and future of a manmade epidemic
Røe, Oluf Dimitri; Stella, Giulia Maria (Journal article; Peer reviewed, 2015)Asbestos is the term for a family of naturally occurring minerals that have been used on a small scale since ancient times. Industrialisation demanded increased mining and refining in the 20th century, and in 1960, Wagner, ... -
MDM2 is a useful prognostic biomarker for resectable gastric cancer
Ye, Yang; Li, Xuan; Yang, Jiangjing; Miao, Shuhan; Wang, Shouyu; Chen, Yansu; Xia, Xiaowei; Wu, Xuming; Zhang, Jianbing; Zhou, Yan; He, Song; Tan, YongFei; Qiang, FuLin; Li, Gang; Røe, Oluf Dimitri; Zhou, Jianwei (Journal article; Peer reviewed, 2013)Expression of MDM2 protein appears to be increased in malignancy and correlated to prognosis of tumors, but its role in gastric cancer remains controversial. Our recent investigations indicated that JWA was a novel candidate ... -
Molecular Resistance Fingerprint of Pemetrexed and Platinum in a Long-Term Survivor of Mesothelioma
Røe, Oluf Dimitri; Szulkin, Adam; Anderssen, Endre; Flatberg, Arnar; Sandeck, Helmut; Amundsen, Tore; Erlandsen, Sten Even; Dobra, Katalin; Sundstrøm, Stein Harald (Journal article; Peer reviewed, 2012) -
Non-occupational exposure to asbestos is the main cause of malignant mesothelioma in women in North Jutland, Denmark
Panou, Vasiliki; Vyberg, Mogens; Meristoudis, Christos; Hansen, Johnni; Bøgsted, Martin; Omland, Øyvind; Weinreich, Ulla Møller; Røe, Oluf Dimitri (Peer reviewed; Journal article, 2019)Objectives Diffuse malignant mesothelioma (MM) is mainly caused by asbestos inhalation. The malignancy is rare among women and studies of the prevalence and causative role of non-occupational asbestos exposure among women ... -
Prognostic role of microscopically positive margins for primary gastrointestinal stromal tumors: a systematic review and meta-analysis
Zhi, Xiaofei; Jiang, Baofei; Yu, Junbo; Røe, Oluf Dimitri; Qin, Jun; Ni, Qingfeng; Sun, Luning; Xu, Meirong; Zhu, Jianwei; Ma, Lilin (Peer reviewed; Journal article, 2016)The impact and management of microscopically positive margins in gastrointestinal stromal tumors (GISTs) remain unclear. The aim of this study is to estimate the prognostic value of surgical margins for disease-free survival ...