Blar i NTNU Open på forfatter "Ræder, Synnøve Brandt"
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Activation of multiple stress responses in Staphylococcus aureus substantially lowers the minimal inhibitory concentration when combining two novel antibiotic drug candidates
Singleton, Amanda Holstad; Bergum, Olaug Elisabeth Torheim; Søgaard, Caroline Krogh; Røst, Lisa M.; Olsen, Cecilie Elisabeth; Blindheim, Fredrik Heen; Ræder, Synnøve Brandt; Bjørnstad, Frithjof Andreas; Sundby, Eirik; Hoff, Bård Helge; Bruheim, Per; Otterlei, Marit (Peer reviewed; Journal article, 2023)The past few decades have been plagued by an increasing number of infections caused by antibiotic resistant bacteria. To mitigate the rise in untreatable infections, we need new antibiotics with novel targets and drug ... -
APIM-Mediated REV3L-PCNA Interaction Important for Error Free TLS Over UV-Induced DNA Lesions in Human Cells
Ræder, Synnøve Brandt; Nepal, Anala; Bjørås, Karine; Seelinger, Mareike; Kolve, Rønnaug Steen; Nedal, Aina; Müller, Rebekka; Otterlei, Marit (Journal article; Peer reviewed, 2018)Proliferating cell nuclear antigen (PCNA) is essential for the organization of DNA replication and the bypass of DNA lesions via translesion synthesis (TLS). TLS is mediated by specialized DNA polymerases, which all interact, ... -
Broad-Spectrum Antibacterial Peptide Kills Extracellular and Intracellular Bacteria Without Affecting Epithelialization
Nepal, Anala; Ræder, Synnøve Brandt; Søgaard, Caroline Krogh; Haugan, Maria Schei; Otterlei, Marit (Peer reviewed; Journal article, 2021)New antibacterial drugs with novel modes of action are urgently needed as antibiotic resistance in bacteria is increasing and spreading throughout the world. In this study, we aimed to explore the possibility of using ... -
Development and Optimization of a Screen for Determining Reduced Sensitivity to the Antimicrobial Peptide Betatide in 4,000 Non-Essential Single Gene Knockouts of Escherichia coli
Johnsen, Norun (Master thesis, 2022)Abstract will be available on 2075-07-01 -
Novel Peptides Targeting the β-Clamp Rapidly Kill Planktonic and Biofilm Staphylococcus epidermidis Both in vitro and in vivo
Ræder, Synnøve Brandt; Sandbakken, Erik Thorvaldsen; Nepal, Anala; Løseth, Kirsti; Bergh, Kåre; Witsø, Eivind; Otterlei, Marit (Peer reviewed; Journal article, 2021)Antimicrobial resistance is an increasing threat to global health and challenges the way we treat infections. Peptides containing the PCNA interacting motif APIM (APIM-peptides) were recently shown to bind to the bacterial ... -
Nucleoside Analogues Are Potent Inducers of Pol V-mediated Mutagenesis
Sumabe, Balagra Kasim; Ræder, Synnøve Brandt; Røst, Lisa M.; Sharma, Animesh; Donkor, Eric S.; Mosi, Lydia; Duodu, Samuel; Bruheim, Per; Otterlei, Marit (Peer reviewed; Journal article, 2021)Drugs targeting DNA and RNA in mammalian cells or viruses can also affect bacteria present in the host and thereby induce the bacterial SOS system. This has the potential to increase mutagenesis and the development of ... -
Nucleoside Analogues Are Potent Inducers of Pol V-mediated Mutagenesis
Sumabe, Balagra Kasim; Ræder, Synnøve Brandt; Røst, Lisa M.; Sharma, Animesh; Donkor, Eric S.; Mosi, Lydia; Duodu, Samuel; Bruheim, Per; Otterlei, Marit (Journal article; Peer reviewed, 2021)Drugs targeting DNA and RNA in mammalian cells or viruses can also affect bacteria present in the host and thereby induce the bacterial SOS system. This has the potential to increase mutagenesis and the development of ... -
Peptides containing the PCNA interacting motif APIM bind to the beta-clamp and inhibit bacterial growth and mutagenesis
Nedal, Aina; Ræder, Synnøve Brandt; Dalhus, Bjørn; Helgesen, Emily; Forstrøm, Rune Johansen; Lindland, Kim; Sumabe, Balagra Kasim; Martinsen, Jacob H.; Kragelund, Birthe B.; Skarstad, Kirsten Jane; Bjørås, Magnar; Otterlei, Marit (Journal article; Peer reviewed, 2020)In the fight against antimicrobial resistance, the bacterial DNA sliding clamp, β-clamp, is a promising drug target for inhibition of DNA replication and translesion synthesis. The β-clamp and its eukaryotic homolog, PCNA, ... -
Targeting translesion synthesis by inhibiting protein interactions of the DNA sliding clamps
Ræder, Synnøve Brandt (Doctoral theses at NTNU;2019:354, Doctoral thesis, 2019)