• FKBP12 is a major regulator of ALK2 activity in multiple myeloma cells 

      Quist-Løkken, Ingrid; Andersson-Rusch, Clara Leticia; Kastnes, Martin Haugrud; Jürgen Markus Kolos, , Jürgen Markus; Jatzlau, Jerome; Hella, Hanne; Olsen, Oddrun Elise; Sundan, Anders; Knaus, Petra; Hausch, Felix; Holien, Toril (Journal article; Peer reviewed, 2023)
      Background: The immunophilin FKBP12 binds to TGF-β family type I receptors, including the BMP type I receptor ALK2. FKBP12 keeps the type I receptor in an inactive state and controls signaling activity. Removal of FKBP12 ...
    • Genredigering i myelomcellinjer med hjälp av CRISPR/Cas9-teknik 

      Wadman, Wilma (Bachelor thesis, 2023)
      Multipelt myelom eller myelom är en benmärgscancer som drabbar de vita blodkropparna. Myelom är en sjukdom som skördar många liv varje år, framför allt då det idag inte finns någon botande behandling. Därav är det av stort ...
    • High concentrations of soluble endoglin can inhibit BMP9 signaling in non-endothelial cells 

      Andersson-Rusch, Clara Leticia; Liu, Bin; Quist-Løkken, Ingrid; Upton, Paul D.; Olsen, Oddrun Elise; Hella, Hanne; Yang, Xudong; Tong, Zhen; Morrell, Nicholas W.; Holien, Toril; Li, Wei (Peer reviewed; Journal article, 2023)
      Endoglin (ENG) is a single-pass transmembrane protein highly expressed on vascular endothelial cells, although low expression levels can be detected in many other cell types. Its extracellular domain can be found in ...
    • Picomolar FKBP inhibitors enabled by a single water-displacing methyl group in bicyclic [4.3.1] aza-amides 

      Kolos, Jürgen M; Pomplun, Sebastian; Jung, Sascha; Rieß, Benedikt; Purder, Patrick L; Voll, Andreas M; Merz, Stephanie; Gnatzy, Monika; Geiger, Thomas M; Quist-Løkken, Ingrid; Jatzlau, Jerome; Knaus, Petra; Holien, Toril; Bracher, Andreas; Meyners, Christian; Czodrowski, Paul; Krewald, Vera; Hausch, Felix (Journal article; Peer reviewed, 2021)
      Methyl groups can have profound effects in drug discovery but the underlying mechanisms are diverse and incompletely understood. Here we report the stereospecific effect of a single, solvent-exposed methyl group in bicyclic ...