• Direct inhibition of c-Myc-Max heterodimers by celastrol and celastrol-inspired triterpenoids 

      Wang, Huabo; Teriete, Peter; Hu, Angela; Raveendra-Panickar, Dhanya; Pendelton, Kelsey; Lazo, John S; Eiseman, Julie; Holien, Toril; Misund, Kristine; Oliynyk, Ganna; Arsenian-Henriksson, Marie; Cosford, Nicholas DP; Sundan, Anders; Prochownik, Edward V (Journal article; Peer reviewed, 2015)
      Many oncogenic signals originate from abnormal protein-protein interactions that are potential targets for small molecule inhibitors. However, the therapeutic disruption of these interactions has proved elusive. We report ...
    • Perturbation of the c-Myc-Max Protein-Protein Interaction via Synthetic α-Helix Mimetics 

      Jung, Kwan-Young; Wang, Huabo; Teriete, Peter; Yap, Jeremy L; Chen, Lijia; Lanning, Maryanna E; Hu, Angela; Lambert, Lester J; Holien, Toril; Sundan, Anders; Cosford, Nicholas D P; Prochownik, Edward V; Fletcher, Steven (Journal article; Peer reviewed, 2015)
      The rational design of inhibitors of the bHLH-ZIP oncoprotein c-Myc is hampered by a lack of structure in its monomeric state. We describe herein the design of novel, low-molecular-weight, synthetic α-helix mimetics that ...