• Causal relationship between obesity and vitamin D status: bi-directional Mendelian randomization analysis of multiple cohorts 

      Vimaleswaran, KS; Berry, DJ; Lu, C; Tikkanen, E; Pilz, Stefan; Hiraki, LT; Cooper, JD; Dastani, Z; Li, R; Houston, Denise; Wood, Andrew R.; Michaëlsson, Karl; Vandenput, Liesbeth; Zgaga, Lina; Yerges-Armstrong, Laura M.; McCarthy, Mark I.; Dupuis, Josée; Kaakinen, Marika; Kleber, Marcus E.; Jameson, Karen; Arden, Nigel; Raitakari, Olli; Vikari, Jorma; Lohman, Kurt K.; Ferrucci, Luigi; Melhus, Håkan; Ingelsson, Erik; Byberg, Liisa; Lind, Lars; Lorentzon, Mattias; Salomaa, Veikko; Campbell, Harry; Dunlop, Malcolm; Mitchell, Braxton D.; Herzig, Karl-Heinz; Pouta, Anneli; Hartikainen, Anna-Liisa; Kvaløy, Kirsti; Midthjell, Kristian; Hveem, Kristian; Platou, Carl Geoffrey Parrinder; Streeten, Elizabeth A.; Theodoratou, Evropi; Jula, Antti; Wareham, Nicholas J.; Ohlsson, Claes; Frayling, Timothy M.; Kritchevsky, Stephen B.; Spector, Timothy D.; Richards, J. Brent; Lehtimäki, Terho; Ouwehand, Willem H.; Kraft, Peter; Cooper, Cyrus; Loos, RJF (Journal article; Peer reviewed, 2013)
      Background Obesity is associated with vitamin D deficiency, and both are areas of active public health concern. We explored the causality and direction of the relationship between body mass index (BMI) and 25-hydroxyvitamin ...
    • Characteristics of preeclampsia in donor cell gestations 

      Ervaala, Attina; Laivuori, Hannele; Gissler, Mika; Kere, Juha; Kivinen, Katja; Pouta, Anneli; Kajantie, Eero Olavi; Heinonen, Seppo; Wedenoja, Satu (Peer reviewed; Journal article, 2022)
      Pregnancies conceived through donor oocytes or sperm show increased risk for preeclampsia. We studied this issue in a preeclampsia case-control cohort (n = 2778), and found overrepresentation of donor cell gestations among ...
    • Circulating Levels of Anti-C1q and Anti-Factor H Autoantibodies and Their Targets in Normal Pregnancy and Preeclampsia 

      Dijkstra, Douwe Jan; Lokki, A Inkeri; Gierman, Lobke; Borggreven, Nicole Veronique; van der Keur, Carin; Eikmans, Michael; Gelderman, Kyra Andrea; Laivuori, Hannele; Heinonen, Seppo; Kajantie, Eero Olavi; Kere, Juha; Kivinen, Katja; Pouta, Anneli; Iversen, Ann-Charlotte; van der Hoorn, Marie-Louise P; Trouw, Leendert Adrianus (Peer reviewed; Journal article, 2022)
      Preeclampsia (PE) generally manifests in the second half of pregnancy with hypertension and proteinuria. The understanding of the origin and mechanism behind PE is incomplete, although there is clearly an immune component ...
    • Genome-wide association scan identifies a risk locus for preeclampsia on 2q14, near the inhibin, beta B gene 

      Johnson, Matthew P; Brennecke, Shaun P.; East, Christine; Göring, Harald H H; Kent, Jack W; Dyer, Thomas D.; Said, Joanne M; Roten, Linda Tømmerdal; Iversen, Ann-Charlotte; Abraham, Lawrence J; Heinonen, Seppo; Kajantie, Eero; Kere, Juha; Kivinen, Katja; Pouta, Anneli; Laivuori, Hannele; Austgulen, Rigmor; Blangero, John; Moses, Eric K (Journal article; Peer reviewed, 2012)
      Elucidating the genetic architecture of preeclampsia is a major goal in obstetric medicine. We have performed a genome-wide association study (GWAS) for preeclampsia in unrelated Australian individuals of Caucasian ancestry ...
    • Gestational diabetes is associated with the risk of offspring's congenital anomalies: a register-based cohort study 

      Kinnunen, Jenni; Nikkinen, Hilkka; Keikkala, Elina; Mustaniemi, Sanna; Gissler, Mika; Laivuori, Hannele; Eriksson, Johan G.; Kaaja, Risto; Pouta, Anneli; Kajantie, Eero Olavi; Vääräsmäki, Marja (Peer reviewed; Journal article, 2023)
      Background Gestational diabetes mellitus (GDM) is a common pregnancy-related disorder and a well-known risk factor for adverse pregnancy outcomes. There are conflicting findings on the association of GDM with the risk of ...
    • Increased Oral Care Needs and Third Molar Symptoms in Women with Gestational Diabetes Mellitus: A Finnish Gestational Diabetes Case-Control Study 

      Pukkila, Jenni; Mustaniemi, Sanna; Lingaiah, Shilpa; Lappalainen, Olli-Pekka; Kajantie, Eero Olavi; Pouta, Anneli; Kaaja, Risto; Eriksson, Johan G.; Laivuori, Hannele; Gissler, Mika; Vääräsmäki, Marja; Keikkala, Elina (Peer reviewed; Journal article, 2022)
      (1) Hyperglycemia and oral pathology accelerate each other in diabetes. We evaluated whether gestational diabetes mellitus (GDM) is associated with self-reported increased oral health care needs and oral symptoms, including ...
    • Normal Gestational Weight Gain Protects From Large-for-Gestational-Age Birth Among Women With Obesity and Gestational Diabetes 

      Mustaniemi, Sanna; Nikkinen, Hilkka; Bloigu, Aini; Pouta, Anneli; Kaaja, Risto; Eriksson, Johan G.; Laivuori, Hannele; Gissler, Mika; Kajantie, Eero Olavi; Vääräsmäki, Marja (Peer reviewed; Journal article, 2021)
      Background: Pre-pregnancy obesity, excess gestational weight gain (GWG), and gestational diabetes (GDM) increase fetal growth. Our aim was to assess whether normal GWG is associated with lower risk for a large-for-gestational-age ...
    • Pregnancy outcomes according to the definition of gestational diabetes 

      Koivunen, Sanna; Viljakainen, Matti; Männistö, Tuija; Gissler, Mika; Pouta, Anneli; Kaaja, Risto; Eriksson, Johan G.; Laivuori, Hannele; Kajantie, Eero Olavi; Vääräsmäki, Marja (Peer reviewed; Journal article, 2020)
      Objective To assess the frequency and perinatal outcomes of gestational diabetes mellitus (GDM) defined by the criteria according to the International Association of Diabetes in Pregnancy Study Group (IADPSG) and the ...
    • Serum ceramides in early pregnancy as predictors of gestational diabetes 

      Mustaniemi, Sanna; Keikkala, Elina; Kajantie, Eero Olavi; Nurhonen, Markku; Jylhä, Antti; Morin-Papunen, Laure; Öhman, Hanna; Männistö, Tuija; Laivuori, Hannele; Eriksson, Johan G.; Laaksonen, Reijo; Vääräsmäki, Marja; Kaaja, Risto; Gissler, Mika; Pouta, Anneli (Peer reviewed; Journal article, 2023)
      Ceramides contribute to the development of type 2 diabetes but it is uncertain whether they predict gestational diabetes (GDM). In this multicentre case–control study including 1040 women with GDM and 958 non-diabetic ...