Browsing NTNU Open by Author "Polyak, Stephen J."

Now showing items 1-3 of 3

    • Discovery of host-directed modulators of virus infection by probing the SARS-CoV-2–host protein–protein interaction network 

      Vandana, Vandana; Aittokallio, Tero Antero; Frigessi, Arnoldo; Athanasiadis, Paschalis; Wagoner, Jessica; Hartigh, Andreas B Den; Sidorova, Julia; Ianevski, Aleksandr; Fink, Susan L.; White, Judith M.; Polyak, Stephen J. (Peer reviewed; Journal article, 2022)
      The ongoing coronavirus disease 2019 (COVID-19) pandemic has highlighted the need to better understand virus–host interactions. We developed a network-based method that expands the severe acute respiratory syndrome ...

    • Drug Combinations as a First Line of Defense against Coronaviruses and Other Emerging Viruses 

      White, Judith M.; Schiffer, Joshua T.; Bender Ignacio, Rachel A.; Xu, Shuang; Kainov, Denis; Ianevski, Aleksandr; Aittokallio, Tero Antero; Frieman, Matthew; Olinger, Gene G.; Polyak, Stephen J. (Journal article; Peer reviewed, 2021)
      The world was unprepared for coronavirus disease 2019 (COVID-19) and remains ill-equipped for future pandemics. While unprecedented strides have been made developing vaccines and treatments for COVID-19, there remains a ...

    • Mono- and combinational drug therapies for global viral pandemic preparedness 

      Ianevski, Aleksandr; Yao, Rouan; Simonsen, Ronja Meyer; Myhre, Vegard; Ravlo, Erlend; Kaynova, Gerda D.; Zusinaite, Eva; White, Judith M.; Polyak, Stephen J.; Oksenych, Valentyn; Windisch, Marc P.; Pan, Qiuwei; Lastauskienė, Eglė; Vitkauskienė, Astra; Matukevičius, Algimantas; Tenson, Tanel; Bjørås, Magnar; Kainov, Denis (Peer reviewed; Journal article, 2022)
      Broadly effective antiviral therapies must be developed to be ready for clinical trials, which should begin soon after the emergence of new life-threatening viruses. Here, we pave the way towards this goal by reviewing ...