Browsing NTNU Open by Author "Pedersen, Dennis V."

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A complement C3–Specific nanobody for modulation of the alternative cascade identifies the C-Terminal domain of C3b as functional in C5 convertase activity

Pedersen, Henrik; Jensen, Rasmus K.; Jensen, Jens Magnus B.; Fox, Rachel; Pedersen, Dennis V.; Olesen, Heidi G.; Hansen, Annette G.; Christiansen, Dorte; Mazarakis, Sofia M.M.; Lojek, Neal; Hansen, Pernille; Gadeberg, Trine A.F.; Zarantonello, Alessandra; Laursen, Nick S.; Mollnes, Tom Eirik; Johnson, Matthew B.; Stevens, Beth; Thiel, Steffen; Andersen, Gregers R. (Peer reviewed; Journal article, 2020)

The complement system is an intricate cascade of the innate immune system and plays a key role in microbial defense, inflammation, organ development, and tissue regeneration. There is increasing interest in developing ...
Soluble collectin-12 mediates C3-independent docking of properdin that activates the alternative pathway of complement

Zhang, Jie; Song, Lihong; Pedersen, Dennis V.; Li, Anna; Lambris, John D.; Andersen, Gregers Rom; Mollnes, Tom Eirik; Ma, Ying Jie; Garred, Peter (Peer reviewed; Journal article, 2020)

Properdin stabilizes the alternative C3 convertase (C3bBb), whereas its role as pattern-recognition molecule mediating complement activation is disputed for decades. Previously, we have found that soluble collectin-12 ...