• The Mammalian Cap-Specific m<sup>6</sup>Am RNA Methyltransferase PCIF1 Regulates Transcript Levels in Mouse Tissues 

      Pandey, Radha Raman; Delfino, Elena; Homolka, David; Roithova, Adriana; Chen, Kuan-Ming; Li, Lingyun; Franco, Giulia; Vågbø, Cathrine Broberg; Taillebourg, Emmanuel; Fauvarque, Marie-Odile; Pillai, Ramesh S. (Peer reviewed; Journal article, 2020)
      The 5′ end of eukaryotic mRNAs is protected by the m7G-cap structure. The transcription start site nucleotide is ribose methylated (Nm) in many eukaryotes, whereas an adenosine at this position is further methylated at the ...
    • Splice site m<sup>6</sup>A methylation prevents binding of U2AF35 to inhibit RNA splicing 

      Mendel, Mateusz; Delaney, Kamila; Pandey, Radha Raman; Chen, Kuan-Ming; Wenda, Joanna M.; Vågbø, Cathrine Broberg; Steiner, Florian A.; Homolka, David; Pillai, Ramesh S. (Journal article; Peer reviewed, 2021)
      The N6-methyladenosine (m6A) RNA modification is used widely to alter the fate of mRNAs. Here we demonstrate that the C. elegans writer METT-10 (the ortholog of mouse METTL16) deposits an m6A mark on the 3′ splice site ...