• Intestinal Epithelial Cell-Intrinsic Deletion of Setd7 Identifies Role for Developmental Pathways in Immunity to Helminth Infection 

      Oudhoff, Menno; Antignano, Frann; Chenery, Alistair L; Burrows, Kyle; Redpath, Stephen A; Braam, Mitchell J; Perona-Wright, Georgia; Zaph, Colby (Journal article; Peer reviewed, 2016)
      The intestine is a common site for a variety of pathogenic infections. Helminth infections continue to be major causes of disease worldwide, and are a significant burden on health care systems. Lysine methyltransferases ...
    • LSD1 represses a neonatal/reparative gene program in adult intestinal epithelium 

      Zwiggelaar, Rosalie; Lindholm, Håvard Takle; Fosslie, Madeleine Lystad; Pedersen, Marianne Terndrup; Ohta, Yuki; Díez-Sánchez, Alberto; Martín-Alonso, Mara; Ostrop, Jenny; Matono, Mami; Parmar, Naveen; Kvaløy, Emilie; Spanjers, Roos; Nazmi, Kamran; Rye, Morten Beck; Drabløs, Finn; Arrowsmith, Cheryl H; Dahl, John Arne; Jensen, Kim B.; Sato, Toshiro; Oudhoff, Menno (Journal article; Peer reviewed, 2020)
      Intestinal epithelial homeostasis is maintained by adult intestinal stem cells, which, alongside Paneth cells, appear after birth in the neonatal period. We aimed to identify regulators of neonatal intestinal epithelial ...
    • Matrix Metalloproteinase (MMP)-17 Regulates Intestinal Regeneration after Irradiation 

      Hoel, Sigrid (Master thesis, 2019)
      The intestinal epithelium is a multitasking tissue and has a large flexibility to adapt to different types of insults. This is mostly due to the proliferative intestinal stem cells (ISCs) at the bottom of the intestinal ...
    • SETD7 Controls Intestinal Regeneration and Tumorigenesis by Regulating Wnt/β-Catenin and Hippo/YAP Signaling 

      Oudhoff, Menno; Braam, Mitchell JS; Freeman, Spencer A; Wong, Denise; Rattray, David G; Wang, Jia; Antignano, Frann; Snyder, Kimberly; Refaeli, Ido; Hughes, Michael R; McNagny, Kelly M; Gold, Michael R; Arrowsmith, Cheryl H; Sato, Toshiro; Rossi, Fabio MV; Tatlock, John H; Owen, Dafydd R; Brown, Peter J; Zaph, Colby (Journal article; Peer reviewed, 2016)
      Intestinal tumorigenesis is a result of mutations in signaling pathways that control cellular proliferation, differentiation, and survival. Mutations in the Wnt/β-catenin pathway are associated with the majority of intestinal ...
    • Unraveling the role of LSD1 in murine intestinal epithelial development 

      Kvaløy, Emilie (Master thesis, 2019)
      Background: The intestinal epithelium is a vital organ that absorbs nutrients and water from luminal contents and provide protection against pathogens and chemicals through the stimulation of the immune system and secretion ...