• Deletion of aquaporin-4 improves capillary blood flow distribution in brain edema 

      Bordoni, Luca; Thorén, Anna Elisabeth; Gutiérrez-Jiménez, Eugenio; Åbjørsbråten, Knut Sindre; Bjørnstad, Daniel Marelius; Tang, Wannan; Stern, Mette; Østergaard, Leif; Nagelhus, Erlend Arnulf; Frische, Sebastian; Ottersen, Ole Petter; Enger, Rune (Peer reviewed; Journal article, 2023)
      Brain edema is a feared complication to disorders and insults affecting the brain. It can be fatal if the increase in intracranial pressure is sufficiently large to cause brain herniation. Moreover, accruing evidence ...
    • Impaired astrocytic Ca2+ signaling in awake-behaving Alzheimer’s disease transgenic mice 

      Åbjørsbråten, Knut Sindre; Skaaraas, Gry HE Syverstad; Cunen, Celine Marie Løken; Bjørnstad, Daniel Marelius; Binder, Kristin M Gullestad; Bojarskaite, Laura; Jensen, Vidar; Nilsson, Lars; Rao, Shreyas B.; Tang, Wannan; Hermansen, Gudmund Horn; Nagelhus, Erlend Arnulf; Ottersen, Ole Petter; Torp, Reidun; Enger, Rune (Peer reviewed; Journal article, 2022)
      Increased astrocytic Ca2+ signaling has been shown in Alzheimer’s disease mouse models, but to date no reports have characterized behaviorally induced astrocytic Ca2+ signaling in such mice. Here, we employ an event-based ...
    • Interstitial solute transport in 3D reconstructed neuropil occurs by diffusion rather than bulk flow 

      Holter, Karl Erik; Kehlet, Benjamin Dam; Devor, Anna; Sejnowski, Terrence J.; Dale, Anders M.; Omholt, Stig William; Ottersen, Ole Petter; Nagelhus, Erlend Arnulf; Mardal, Kent-Andre; Pettersen, Klas (Journal article; Peer reviewed, 2017)
      The brain lacks lymph vessels and must rely on other mechanisms for clearance of waste products, including amyloid β that may form pathological aggregates if not effectively cleared. It has been proposed that flow of ...
    • Loss or mislocalization of aquaporin-4 affects diffusion properties and intermediary metabolism in gray matter of mice 

      Pavlin, Tina; Nagelhus, Erlend Arnulf; Brekken, Christian; Eyjolfsson, Elvar M.; Thoren, Anna; Haraldseth, Olav; Sonnewald, Ursula; Ottersen, Ole Petter; Håberg, Asta (Journal article; Peer reviewed, 2017)
      The first aim of this study was to determine how complete or perivascular loss of aquaporin-4 (AQP4) water channels affects membrane permeability for water in the mouse brain grey matter in the steady state. Time-dependent ...