• Characterization of FGD5 expression in primary breast cancers and lymph node metastases 

      Valla, Marit; Mjønes, Patricia; Engstrøm, Monica J; Ytterhus, Borgny; Bordin, Diana Lilian; van Loon, Barbara; Akslen, Lars A.; Vatten, Lars Johan; Opdahl, Signe; Bofin, Anna M. (Journal article; Peer reviewed, 2018)
      Faciogenital dysplasia 5 (FGD5) amplification drives tumor cell proliferation, and is present in 9.5% of breast cancers. We describe FGD5 expression, assess associations between FGD5 amplification and FGD5 expression, and ...
    • Data resource profile: the Committee of Nordic Assisted Reproductive Technology and Safety (CoNARTaS) cohort 

      Opdahl, Signe; Henningsen, Anna-Karina Aaris; Bergh, Christina; Gissler, Mika; Romundstad, Liv Bente Bergem; Petzold, Max; Tiitinen, Aila; Wennerholm, Ulla-Britt; Pinborg, Anja (Journal article; Peer reviewed, 2019)
    • Effect of Paternal Age on Reproductive Outcome in Assisted Reproductive Technology Compared to Spontanous Conception 

      Evensen, Mari; Kvalheim, Stine (Master thesis, 2016)
      Studies investigating the role of increasing paternal age for neonatal health in pregnancies following assisted reproductive technology (ART) are limited. In this large cohort study, we evaluated the association between ...
    • FGD5 amplification in breast cancer patients is associated with tumor proliferation and a poorer prognosis 

      Valla, Marit; Engstrøm, Monica J; Ytterhus, Borgny; Hansen, Åse Kristin Skain; Akslen, Lars A.; Vatten, Lars Johan; Opdahl, Signe; Bofin, Anna M. (Journal article; Peer reviewed, 2017)
      Purpose Proliferation is a hallmark of cancer. Using a combined genomic approach, FGD5 amplification has been identified as a driver of proliferation in Luminal breast cancer. We aimed to describe FGD5 copy number change ...
    • Invasive lobular breast cancer: The prognostic impact of histopathological grade, E-cadherin and molecular subtypes 

      Engstrøm, Monica J; Opdahl, Signe; Vatten, Lars Johan; Haugen, Olav Anton; Bofin, Anna M. (Peer reviewed; Journal article, 2015)
      Aims The aim of this study was to compare breast cancer specific survival (BCSS) for invasive lobular carcinoma (ILC) and invasive ductal carcinoma (IDC) and, further, to evaluate critically the prognostic value of ...
    • Menopausal hormone therapy and breast cancer risk: effect modification by body mass through life 

      Sandvei, Marie Søfteland; Vatten, Lars Johan; Bjelland, Elisabeth Krefting; Eskild, Anne; Hofvind, Solveig; Ursin, Giske; Opdahl, Signe (Journal article; Peer reviewed, 2018)
      It is not known whether increased breast cancer risk caused by menopausal hormone therapy (HT) depends on body mass patterns through life. In a prospective study of 483,241 Norwegian women aged 50–69 years at baseline, ...
    • Microvascular proliferation in luminal A and basal-like breast cancer subtypes 

      Kraby, Maria Ryssdal; Krüger, Kristi; Opdahl, Signe; Vatten, Lars Johan; Akslen, Lars A.; Bofin, Anna M. (Journal article; Peer reviewed, 2015)
      Aims The aims of this study were to examine microvessel density (MVD), proliferating MVD (pMVD) and Vascular Proliferation Index (VPI) in basal-like phenotype (BP) and luminal A subtypes of breast cancer and to study their ...
    • Molecular subtypes of breast cancer: incidence and prognosis 

      Valla, Marit (Doctoral theses at NTNU;2017:276, Doctoral thesis, 2017)
      Forekomsten av brystkreft har over flere tiår økt i den vestlige verden, og i Norge har det vært en dobling av insidensen siden Kreftregisteret startet sin overvåkning av antall krefttilfeller i Norge i 1952. I Norge har ...
    • Molecular Subtypes of Breast Cancer: Long-term Incidence Trends and Prognostic Differences 

      Valla, Marit; Vatten, Lars Johan; Engstrøm, Monica J; Haugen, Olav Anton; Akslen, Lars A.; Bjørngaard, Johan Håkon; Hagen, Anne Irene; Ytterhus, Borgny; Bofin, Anna M.; Opdahl, Signe (Journal article; Peer reviewed, 2016)
      Background: Secular trends in incidence and prognosis of molecular breast cancer subtypes are poorly described. We studied long-term trends in a population of Norwegian women born 1886–1977. Methods: A total of 52,949 ...
    • Molecular subtypes, histopathological grade and survival in a historic cohort of breast cancer patients 

      Engstrøm, Monica J; Opdahl, Signe; Hagen, Anne Irene; Romundstad, Pål Richard; Akslen, Lars A.; Haugen, Olav A.; Vatten, Lars Johan; Bofin, Anna M. (Peer reviewed; Journal article, 2013)
      Molecular subtyping of breast cancer may provide additional prognostic information regarding patient outcome. However, its clinical significance remains to be established. In this study, the main aims were to discover ...
    • MRPS23 amplification and gene expression in breast cancer; association with proliferation and the non-basal subtypes 

      Klæstad, Elise; Opdahl, Signe; Engstrøm, Monica J; Ytterhus, Borgny; Wik, Elisabeth; Bofin, Anna Mary; Valla, Marit (Peer reviewed; Journal article, 2020)
      Purpose MRPS23 is recognized as a driver of proliferation in luminal breast cancer. The aims of the present study were to describe MRPS23 copy number change in breast cancer, and to assess associations between MRPS23 ...
    • Obesity and health in pregnancies after assisted reproductive technology 

      Johannessen, Heidi Grue (Master thesis, 2017)
      Objective: To compare the association of maternal pre-pregnancy body mass index (BMI) with adverse perinatal and maternal outcomes in pregnancies following spontaneous and assisted conception in a large nation-wide cohort. ...
    • Pregnancy and breast cancer risk : prospective studies of Norwegian women 

      Opdahl, Signe (Doktoravhandlinger ved NTNU, 1503-8181; 2013:6, Doctoral thesis, 2013)
      Svangerskap og risiko for brystkreft: Prospektive studier av norske kvinner Brystkreft er den vanligste kreftformen blant kvinner i den vestlige verden. I Norge vil nær 10% av alle kvinner få sykdommen i løpet av livet. ...
    • Quantifying tumour vascularity in non-luminal breast cancers 

      Kraby, Maria Ryssdal; Opdahl, Signe; Akslen, Lars A.; Bofin, Anna M. (Journal article; Peer reviewed, 2017)
      Aims Microvessel density (MVD), proliferating MVD (pMVD) and vascular proliferation index (VPI) are methods used to quantify tumour vascularity in histopathological sections. In this study, we assessed MVD, pMVD and VPI ...
    • The prognostic value of androgen receptors in breast cancer subtypes 

      Kraby, Maria Ryssdal; Valla, Marit; Opdahl, Signe; Haugen, Olav Anton; Sawicka, Joanna Ewa; Engstrøm, Monica J; Bofin, Anna M. (Journal article; Peer reviewed, 2018)
      Purpose Androgen receptor (AR) expression is frequent in breast cancer and has been associated with good prognosis in several studies. The present study investigates AR-expression in relation to molecular subtypes, ...
    • TOP2A gene copy number change in breast cancer 

      Engstrøm, Monica J; Ytterhus, Borgny; Vatten, Lars Johan; Opdahl, Signe; Bofin, Anna M. (Peer reviewed; Journal article, 2014)
      Aims The clinical significance of TOP2A as a prognostic marker has not been clarified. The aims of this study were to investigate the frequency of TOP2A copy number change; to correlate TOP2A with HER2 status, hormone ...
    • Tumour Vasculature in Subtypes of Breast Cancer 

      Kraby, Maria Ryssdal (Doctoral theses at NTNU;2019:35, Doctoral thesis, 2019)
      Breast cancer is a group of heterogeneous diseases. Using immunohistochemistry (IHC) and in situ hybridisation (ISH), they can be separated into molecular subtypes with distinct biology and prognosis. The Luminal A subtype ...