• Activin A inhibits BMP-signaling by binding ACVR2A and ACVR2B 

      Olsen, Oddrun Elise; Wader, Karin Fahl; Hella, Hanne; Mylin, Anne K.; Turesson, Ingemar; Nesthus, Ingerid; Waage, Anders; Sundan, Anders; Holien, Toril (Journal article; Peer reviewed, 2015)
      Background: Activins are members of the TGF-β family of ligands that have multiple biological functions in embryonic stem cells as well as in differentiated tissue. Serum levels of activin A were found to be elevated ...
    • Activins as Dual Specificity TGF-β Family Molecules: SMAD-Activation via Activin- and BMP-Type 1 Receptors 

      Olsen, Oddrun Elise; Hella, Hanne; Elsaadi, Samah; Jacobi, Carsten; Martinez-Hackert, Erik; Holien, Toril (Peer reviewed; Journal article, 2020)
      Activins belong to the transforming growth factor (TGF)-β family of multifunctional cytokines and signal via the activin receptors ALK4 or ALK7 to activate the SMAD2/3 pathway. In some cases, activins also signal via the ...
    • Bone morphogenetic protein-9 suppresses growth of myeloma cells by signaling through ALK2 but is inhibited by endoglin 

      Olsen, Oddrun Elise; Wader, Karin Fahl; Misund, Kristine; Våtsveen, Thea Kristin; Rø, Torstein Baade; Mylin, Anne K.; Turesson, I; Størdal, Berit Fladvad; Moen, Siv Helen; Standal, Therese; Waage, Anders; Sundan, Anders; Holien, Toril (Journal article; Peer reviewed, 2014)
      Multiple myeloma is a malignancy of plasma cells predominantly located in the bone marrow. A number of bone morphogenetic proteins (BMPs) induce apoptosis in myeloma cells in vitro, and with this study we add BMP-9 to the ...
    • GDF-15 signalling in multiple myeloma 

      Skjærvik, Anette (Master thesis, 2015)
      Abstract Multiple myeloma (MM), also known as bone marrow cancer, is a malignancy of hypermutated antibody-producing plasma cells in the bone marrow. An accumulation of this antibody (M-protein) can be detected in blood- ...
    • MYC amplifications in myeloma cell lines; correlation with MYC-inhibitor efficacy 

      Holien, Toril; Misund, Kristine; Olsen, Oddrun Elise; Baranowska, Katarzyna Anna; Buene, Glenn; Børset, Magne; Waage, Anders; Sundan, Anders (Journal article; Peer reviewed, 2015)
      In multiple myeloma, elevated MYC expression is related to disease initiation and progression. We found that in myeloma cell lines, MYC gene amplifications were common and correlated with MYC mRNA and protein. In primary ...
    • Potentiation of BMP and activin induced apoptosis in multiple myeloma cells by FK506 

      Booc, Nerissa Rae (Master thesis, 2019)
      Myelomatose er en hematologisk kreft som kjennetegnes av maligne plasmaceller som akkumuleres in benmargen. Akkumulering av myelomceller kan forårsake osteolyse mens monoklonale immunoglobuliner produsert av myelomceller ...
    • RNA-Integrity and 8-Isoprostane Levels Are Stable in Prostate Tissue Samples Upon Long-Term Storage at −80°C 

      Dybos, Sandra Amalie; Winje Brustad, Åge; Rolfseng, Toril F.Langvik; Kvam, Solveig; Olsen, Oddrun Elise; Halgunset, Jostein; Skogseth, Haakon (Peer reviewed; Journal article, 2020)
      Sampling of prostate tissue (n = 97) was performed in conjunction with planned radical prostatectomies, in collaboration with Biobank1®. The tissue used in this study was collected during the period 2003-2016, quickly ...
    • Targeting FKBP12 potentiates bone morphogenetic protein signaling in multiple myeloma cells 

      Kastnes, Martin Haugrud (Master thesis, 2019)
      Abstract Background Multiple myeloma (MM) is a malignancy of terminally differentiated plasma cells. Although new treatments approved in the last decades have improved patient outcomes considerably, most patients relapse ...
    • TGF-β contamination of purified recombinant GDF15 

      Olsen, Oddrun Elise; Skjærvik, Anette; Størdal, Berit Fladvad; Sundan, Anders; Holien, Toril (Journal article; Peer reviewed, 2017)
      Purified recombinant proteins for use in biomedical research are invaluable to investigate protein function. However, purity varies in protein batches made in mammalian expression systems, such as CHO-cells or HEK293-cells. ...
    • The role of BMP receptor ALK2 in myeloma cells 

      Olsen, Oddrun Elise (Doctoral theses at NTNU;2017:65, Doctoral thesis, 2017)
      ROLLEN TIL BMP-RESEPTOR ALK2 I MYELOMCELLER Myelomgruppa ved Institutt for Kreftforskning og Molekylærmedisin ved NTNU i Trondheim har i mange år arbeidet med myelomatose. Myelomatose, også kjent som beinmargskreft, er ...
    • The role of bone morphogenetic protein-9 in multiple myeloma 

      Olsen, Oddrun Elise (Master thesis, 2012)
      Multiple myeloma (MM) is a malignancy of antibody producing plasma cells located in the bone marrow. MM is also called bone marrow cancer and is the second most common hematologic cancer. The exact cause for this type of ...