Browsing NTNU Open by Author "Nordgård, Catherine Taylor"
Now showing items 1-20 of 22
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Biosimilar Mucus as a Model System for Small Intestinal Mucus: -Evaluating the Applicability for Nanoparticle Drug Delivery Studies
Våset, Frida Sandvik (Master thesis, 2014)Slimhinnene i mage/tarm, luftveier og urogenitaliene er store mål for legemiddellevering i kroppen. Mucus blir uskilt fra slimhinnene og kan skape en barriere når legemidler i form av biologiske makromolekyler skal ... -
Characterisation of Macromolecule Diffusion in Internally Set Calcium Alginate Gels
Løberg, Runa Ingrunsdotter (Master thesis, 2021)Alginat er et biomaterial ofte brukt som immobiliseringsmatriks på grunn av dens lave immunogenitet, høye og kontrollerbare porøsitet, at det finnes naturlig i store mengder og at prosesseringskostnadene er lave. For at ... -
Chitosan: Gels and interfacial properties
Nilsen-Nygaard, Julie; Strand, Sabina P.; Vårum, Kjell Morten; Draget, Kurt Ingar; Nordgård, Catherine Taylor (Journal article; Peer reviewed, 2015)Chitosan is a unique biopolymer in the respect that it is abundant, cationic, low-toxic, non-immunogenic and biodegradable. The relative occurrence of the two monomeric building units (N-acetyl-glucosamine and d-glucosamine) ... -
Co association of mucus modulating agents and nanoparticles for mucosal drug delivery
Nordgård, Catherine Taylor; Draget, Kurt Ingar (Journal article; Peer reviewed, 2018)Nanoparticulate drug delivery systems (nDDS) offer a variety of options when it comes to routes of administration. One possible path is crossing mucosal barriers, such as in the airways and in the GI tract, for systemic ... -
Confocal reflectance microscopy and multiple particle tracking for the study of the gelation of biopolymers
Haug, Bente; Nordgård, Catherine Taylor; Draget, Kurt Ingar; Bjørkøy, Astrid (Journal article; Peer reviewed, 2018)The combination of confocal reflectance imaging (CRM) and simultaneous multiple particle tracking (MPT) with mean-square displacement (MSD) analysis is a new method for studying the gelation of biopolymers. In addition to ... -
Direct Determination of Chitosan–Mucin Interactions Using a Single-Molecule Strategy: Comparison to Alginate–Mucin Interactions
Haugstad, Kristin Elisabeth; Håti, Armend Gazmeno; Nordgård, Catherine Taylor; Adl, Patricia S.; Maurstad, Gjertrud; Sletmoen, Marit; Draget, Kurt Ingar; Dias, Rita de Sousa; Stokke, Bjørn Torger (Journal article; Peer reviewed, 2015)Aqueous chitosan possesses attractive interaction capacities with various molecular groups that can be involved in hydrogen bonds and electrostatic and hydrophobic interactions. In the present paper, we report on the direct ... -
Effects of salmon lice treatment on the barrier properties of salmon skin mucus
Banjade, Sushil (Master thesis, 2018)Salmon skin mucus forms a thin physical barrier between the external environment and internal milieu acting as a first line of defence against infection through skin epidermis. In addition, mucus has role in defence mechanism ... -
Elucidating bacterial adhesion to mucosal surface by an original AFM approach
Dunker, Karen; Gomez de la Torre Canny, Sol; Nordgård, Catherine Taylor; Dague, Etienne; Formosa-Dague, Cecile; Bakke, Ingrid; Sletmoen, Marit (Peer reviewed; Journal article, 2021)Background Fish skin represents an ancient vertebrate mucosal surface, sharing characteristics with other mucosal surfaces including those of the intestine. The skin mucosa is continuously exposed to microbes in the ... -
Enzyminhibering av guluronatoligomere i farmasøytiske applikasjoner
Røyrvik, Brita (Master thesis, 2011)Alginat har en lang tradisjon som en allsidig marin ressurs. Det har i en årrekke blitt forsket på mulige anvendelser av alginat. Alginatets gelingsevne er den egenskapen som for det meste er blitt utnyttet. I de senere ... -
Injectable In Situ Crosslinking Hydrogel for Autologous Fat Grafting
Oskarsdotter, Kristin; Nordgård, Catherine Taylor; Apelgren, Peter; Säljö, Karin; Solbu, Anita Akbarzadeh; Eliasson, Edwin; Sämfors, Sanna; Sætrang, Henriette Elisabeth Myhr; Asdahl, Lise Cathrine; Thompson, Eric Malcolm; Troedsson, Christofer; Simonsson, Stina; Strand, Berit Løkensgard; Gatenholm, Paul; Kölby, Lars (Peer reviewed; Journal article, 2023)Autologous fat grafting is hampered by unpredictable outcomes due to high tissue resorption. Hydrogels based on enzymatically pretreated tunicate nanocellulose (ETC) and alginate (ALG) are biocompatible, safe, and present ... -
Investigation of the diffusion barrier properties in mixtures of mammalian and cold-water fish gelatin
Landsem, Kristoffer Gustad (Master thesis, 2023)Diffusjonsbarriereegenskapene til en gel er en av flere viktige faktorer som bidrar til å definere oppførselen og funksjonaliteten til den. Gelatin er en av mange geleringsmiddel som er vidt brukt i industrien i dag, og ... -
Is dehulling of peas and faba beans necessary prior to dry fractionation for the production of protein- and starch-rich fractions? Impact on physical properties, chemical composition and techno-functional properties
do Carmo, Cátia Saldanha; Silventoinen, Pia; Nordgård, Catherine Taylor; Poudroux, Claire; Dessev, Tzevetelin; Zobel, Hanne; Holtekjølen, Ann Katrin; Draget, Kurt Ingar; Holopainen-Mantila, Ulla; Knutsen, Svein Halvor; Sahlstrøm, Stefan (Journal article; Peer reviewed, 2020)Dehulling of peas and faba beans prior to milling and air classification was evaluated, namely its impact on physical properties, chemical composition and techno-functional properties of the fractions. Dry fractionation ... -
Mechanical properties of 67NR tumours are broadly independent of the immune status of the host mouse
Nordgård, Catherine Taylor; Rao, Shalini Vasudev; Dille, Morten Johnsen; Steigedal, Tonje S.; Draget, Kurt Ingar (Journal article; Peer reviewed, 2017)Tumour stiffness is increasingly seen as a clinically relevant parameter, with increased stiffness being linked to poorer prognosis, but it is also one that is not inherently easy to measure either in vivo or ex vivo. We ... -
A novel gnotobiotic experimental system for Atlantic salmon ( Salmo salar L.) reveals a microbial influence on mucosal barrier function and adipose tissue accumulation during the yolk sac stage
Gomez de la Torre Canny, Sol; Nordgård, Catherine Taylor; Mathisen, Amalie johanne Horn; Degré Lorentsen, Eirik; Vadstein, Olav; Bakke, Ingrid (Peer reviewed; Journal article, 2023)Gnotobiotic models have had a crucial role in studying the effect that commensal microbiota has on the health of their animal hosts. Despite their physiological and ecological diversity, teleost fishes are still underrepresented ... -
Penetrating the Mucus Barrier - The Effect of Addition of Guluronate Oligomers on the Mobility of Nanoparticles in Porcine Small Intestinal Mucus
Sørensen, Solveig Lysfjord (Master thesis, 2015)Oral delivery is the easiest and most used method of drug delivery. However, the gastrointestinal (GI) tract poses many hurdles for the drugs to overcome before they can reach their target. One of them is the viscous, ... -
Potential mucus rheological consequences of off target siRNA loaded nanoparticle deposition in the lungs
Katuwal, Nishan; Loretz, Brigitte; Thanki, Kaushik; Hållbrink, Mattias; Lehr, Claus-Michael; Foged, Camilla; Draget, Kurt Ingar; Nordgård, Catherine Taylor (Journal article; Peer reviewed, 2018) -
Rheological properties of gelled emulsions based on mixtures of porcine and piscine gelatin
Sylliåsen, Kristian (Master thesis, 2024)Gelatinbaserte emulsjonsgeler er lovende systemer for peroral levering av medisiner og kosttilskudd, og har blitt kommersialisert i nyere tid. På grunn av suboptimale overgangstemperaturer og lav gelstyrke har gelatin fra ... -
Rheology of skin mucus from yolk-sac salmon fry
Nordgård, Catherine Taylor; Gomez de la Torre Canny, Sol; Dunker, Karen; Sletmoen, Marit; Bakke, Ingrid (Journal article; Peer reviewed, 2020)As part of our project “Microbial contributions to the Atlantic salmon (Salmo salar) skin mucosal barrier” we have explored techniques to investigate and characterise the rheological properties of the skin mucus of yolk-sac ... -
Solubility Patterns in Relation to Coating of Mineral Supplements
Tepstad, Jorunn (Master thesis, 2019)Målet for dette prosjektet var å utvikle et belegg eller en bærer for Bolifor® fosfatsalt som brukes i akvakulturfôr. Bæreren/belegget må være slik at det beskytter fosfatsaltet mot å lekke i vann. Lekking av fosfat er et ... -
The potential of marine oligosaccharides in pharmacy
Nordgård, Catherine Taylor; Rao, Shalini Vasudev; Draget, Kurt Ingar (Journal article; Peer reviewed, 2019)Complex polysaccharides are widespread within the animal kingdom. At the molecular level, however, the importance of such components have largely been considered inferior compared to nucleic acids and proteins. This in ...