• APIM-Mediated REV3L-PCNA Interaction Important for Error Free TLS Over UV-Induced DNA Lesions in Human Cells 

      Ræder, Synnøve Brandt; Nepal, Anala; Bjørås, Karine; Seelinger, Mareike; Kolve, Rønnaug Steen; Nedal, Aina; Müller, Rebekka; Otterlei, Marit (Journal article; Peer reviewed, 2018)
      Proliferating cell nuclear antigen (PCNA) is essential for the organization of DNA replication and the bypass of DNA lesions via translesion synthesis (TLS). TLS is mediated by specialized DNA polymerases, which all interact, ...
    • Novel antibiotic peptides 

      Rindal, Christine Bauer (Master thesis, 2016)
      During bacterial replication DNA lesions might occur and lead to DNA damage. Some lesions are repaired by DNA repair pathways, but this is not always successful. In these cases, instead of repairing the damage, the DNA ...
    • Peptides containing the PCNA interacting motif APIM bind to the beta-clamp and inhibit bacterial growth and mutagenesis 

      Nedal, Aina; Ræder, Synnøve Brandt; Dalhus, Bjørn; Helgesen, Emily; Forstrøm, Rune Johansen; Lindland, Kim; Sumabe, Balagra Kasim; Martinsen, Jacob H.; Kragelund, Birthe B.; Skarstad, Kirsten Jane; Bjørås, Magnar; Otterlei, Marit (Journal article; Peer reviewed, 2020)
      In the fight against antimicrobial resistance, the bacterial DNA sliding clamp, β-clamp, is a promising drug target for inhibition of DNA replication and translesion synthesis. The β-clamp and its eukaryotic homolog, PCNA, ...
    • Post-PKS modifications in the biosynthesis of the antifungal antibiotic nystatin 

      Nedal, Aina (Doktoravhandlinger ved NTNU, 1503-8181; 2007:135, Doctoral thesis, 2007)
      The antifungal polyene macrolide nystatin is produced by Streptomyces noursei ATCC 11455. The nystatin biosynthesis gene cluster of Streptomyces noursei has been cloned and sequenced, and a biosynthesis route has been ...