• Astrocytic Ca2+ signaling is reduced during sleep and is involved in the regulation of slow wave sleep 

      Bojarskaite, Laura; Bjørnstad, Daniel Marelius; Pettersen, Klas; Cunen, Celine; Hermansen, Gudmund Horn; Åbjørsbråten, Knut Sindre; Chambers, Anna; Sprengel, Rolf; Vervaeke, Koen Gerard Alois; Tang, Wannan; Enger, Rune; Nagelhus, Erlend Arnulf (Peer reviewed; Journal article, 2020)
      Astrocytic Ca2+ signaling has been intensively studied in health and disease but has not been quantified during natural sleep. Here, we employ an activity-based algorithm to assess astrocytic Ca2+ signals in the neocortex ...
    • Interstitial solute transport in 3D reconstructed neuropil occurs by diffusion rather than bulk flow 

      Holter, Karl Erik; Kehlet, Benjamin Dam; Devor, Anna; Sejnowski, Terrence J.; Dale, Anders M.; Omholt, Stig William; Ottersen, Ole Petter; Nagelhus, Erlend Arnulf; Mardal, Kent-Andre; Pettersen, Klas (Journal article; Peer reviewed, 2017)
      The brain lacks lymph vessels and must rely on other mechanisms for clearance of waste products, including amyloid β that may form pathological aggregates if not effectively cleared. It has been proposed that flow of ...
    • Loss or mislocalization of aquaporin-4 affects diffusion properties and intermediary metabolism in gray matter of mice 

      Pavlin, Tina; Nagelhus, Erlend Arnulf; Brekken, Christian; Eyjolfsson, Elvar M.; Thoren, Anna; Haraldseth, Olav; Sonnewald, Ursula; Ottersen, Ole Petter; Håberg, Asta (Journal article; Peer reviewed, 2017)
      The first aim of this study was to determine how complete or perivascular loss of aquaporin-4 (AQP4) water channels affects membrane permeability for water in the mouse brain grey matter in the steady state. Time-dependent ...