• Alpha-tocopherol and MRI outcomes in multiple sclerosis - association and prediction 

      Løken-Amsrud, Kristin Ingeleiv; Myhr, Kjell-Morten; Bakke, Søren Jacob; Beiske, Antonie Giæver; Bjerve, Kristian S; Bjørnarå, Bård T.; Hovdal, Harald Olav; Lilleås, Finn; Midgard, Rune; Pedersen, Tom; Saltyte Benth, Jurate; Torkildsen, Øivind; Wergeland, Stig; Holmøy, Trygve (Journal article; Peer reviewed, 2013)
      Objective: Alpha-tocopherol is the main vitamin E compound in humans, and has important antioxidative and immunomodulatory properties. The aim of this study was to study alpha-tocopherol concentrations and their relationship ...
    • Cancer related mortality in multiple sclerosis. A population based cohort study 

      Grytten, Nina; Myhr, Kjell-Morten; Celius, Elisabeth Gulowsen; Benjaminsen, Espen; Midgard, Rune; Vatne, Anita; Aarseth, Jan Harald; Mannseth, Janne; Torkildsen, Øivind Fredvik Grytten (Peer reviewed; Journal article, 2022)
      Background Cancer is a major cause of death, but how cancer influences mortality risk in Multiple Sclerosis (MS) is unclear. Objectives Determine all-cause mortality and mortality following a cancer diagnosis among MS ...
    • The effect of gadolinium-based contrast-agents on automated brain atrophy measurements by FreeSurfer in patients with multiple sclerosis 

      Lie, Ingrid Anne; Kerklingh, Emma; Wesnes, Kristin; van Nederpelt, David R.; Brouwer, Iman; Torkildsen, Øivind; Myhr, Kjell-Morten; Barkhof, Frederik; Bø, Lars; Vrenken, Hugo (Peer reviewed; Journal article, 2022)
      Objective - To determine whether reliable brain atrophy measures can be obtained from post-contrast 3D T1-weighted images in patients with multiple sclerosis (MS) using FreeSurfer. Methods - Twenty-two patients with MS ...
    • The Effect of Smoking on Long-term Gray Matter Atrophy and Clinical Disability in Patients with Relapsing-Remitting Multiple Sclerosis 

      Lie, Ingrid Anne; Wesnes, Kristin; Kvistad, Silje S.; Brouwer, Iman; Wergeland, Stig; Holmøy, Trygve; Midgard, Rune; Bru, Alla Nikolajevna S; Edland, Astrid; Eikeland, Randi; Gosal, Sonia; Harbo, Hanne-Cathrin Flinstad; Kleveland, Grethe; Sørenes, Yvonne; Øksendal, Nina; Barkhof, Frederik; Vrenken, Hugo; Myhr, Kjell-Morten; Bø, Lars; Torkildesen, Øivind (Peer reviewed; Journal article, 2022)
      Background and Objectives - The relationship between smoking, long-term brain atrophy, and clinical disability in patients with multiple sclerosis (MS) is unclear. Here, we assessed long-term effects of smoking by evaluating ...
    • Gut microbiota composition during a 12-week intervention with delayed-release dimethyl fumarate in multiple sclerosis – a pilot trial 

      Storm-Larsen, Christopher; Myhr, Kjell-Morten; Farbu, Elisabeth; Midgard, Rune; Nyquist, Kaja Beate; Broch, Line; Berg-Hansen, Pål; Hov, Johannes Espolin Roksund; Holmøy, Trygve (Journal article; Peer reviewed, 2019)
      Introduction Patients with multiple sclerosis may have a distinct gut microbiota profile. Delayed-release dimethyl fumarate is an orally administered drug for relapsing–remitting multiple sclerosis, which has been ...
    • High incidence and prevalence of MS in Møre and Romsdal County, Norway, 1950–2018 

      Willumsen, Johannes Sverre; Aarseth, Jan Harald; Myhr, Kjell-Morten; Midgard, Rune (Peer reviewed; Journal article, 2020)
      Objective To determine prevalence and longitudinal trends in incidence of MS in Møre and Romsdal County, Western Norway, from 1950 to 2018. Methods Retrospective longitudinal population-based observational study. All ...
    • Incidence of cancer in multiple sclerosis before and after the treatment era– a registry- based cohort study 

      Grytten, Nina; Myhr, Kjell-Morten; Celius, Elisabeth Gulowsen; Benjaminsen, Espen; Kampman, Margitta T.; Midgard, Rune; Vatne, Anita; Aarseth, Jan H.; Riise, Trond; Torkildsen, Øivind (Journal article; Peer reviewed, 2021)
    • Increasing age of multiple sclerosis onset from 1920 to 2022: a population-based study 

      Habbestad, Andrea Kyvik; Willumsen, Johannes Sverre; Aarseth, Jan Harald; Grytten, Nina; Midgard, Rune; Wergeland, Stig; Myhr, Kjell-Morten; Torkildsen, Øivind (Journal article; Peer reviewed, 2023)
      Objective To study the age at onset of relapsing–remitting multiple sclerosis (RRMS) during the past century. Methods This is a population-based cohort study of persons diagnosed with RRMS in Hordaland, Møre, and ...
    • Inflammation markers in multiple sclerosis: CXCL16 reflects and may also predict disease activity 

      Holmøy, Trygve; Løken-Amsrud, Kristin Ingeleiv; Bakke, Jacob; Beiske, Antonie Giæver; Bjerve, Kristian S; Hovdal, Harald Olav; Lilleås, Finn; Midgard, Rune; Pedersen, Tom; Saltyte Benth, Jurate; Torkildsen, Øivind; Wergeland, Stig; Myhr, Kjell-Morten; Michelsen, Annika; Aukrust, Pål; Ueland, Thor (Journal article; Peer reviewed, 2013)
      Background: Serum markers of inflammation are candidate biomarkers in multiple sclerosis (MS). ω-3 fatty acids are suggested to have anti-inflammatory properties that might be beneficial in MS. We aimed to explore ...
    • Level of education and multiple sclerosis risk over a 50-year period: Registry-based sibling study 

      Bjørnevik, Kjetil; Riise, Trond; Benjaminsen, Espen; Celius, Elisabeth Gulowsen; Dahl, Ole-Petter; Kampman, Margitta Theodora; Løken-Amsrud, Kristin Ingeleiv; Midgard, Rune; Myhr, Kjell-Morten; Torkildsen, Øivind; Vatne, Anita; Grytten, Nina (Journal article; Peer reviewed, 2016)
      Background: The conflicting results from studies on socioeconomic status (SES) and multiple sclerosis (MS) risk might be due to a change in the distribution of environmental exposures over time or to methodological ...
    • Low vitamin D, but not tobacco use or high BMI, is associated with long-term disability progression in multiple sclerosis 

      Wesnes, Kristin; Myhr, Kjell-Morten; Riise, Trond; Stokke, Silje Agnethe; Torkildsen, Øivind; Wergeland, Stig; Holmøy, Trygve; Midgard, Rune; Bru, Alla Nikolajevna S; Edland, Astrid; Eikeland, Randi; Gosal, Sonia; Harbo, Hanne Flinstad; Kleveland, Grethe; Sørenes, Yvonne; Øksendal, Nina; Bjørnevik, Kjetil Lauvland (Peer reviewed; Journal article, 2021)
      Background: Low vitamin D levels, tobacco use and high body mass index (BMI) have been linked to adverse disease outcomes in multiple sclerosis (MS), but their influence on long-term disability progression remains unclear. ...
    • Mortality and cause of death in multiple sclerosis in western Norway 1950-2021: A registry-based linkage study 

      Willumsen, Johannes Sverre; Grytten, Nina; Aarseth, Jan Harald; Myklebust, Tor Åge; Myhr, Kjell-Morten; Midgard, Rune (Peer reviewed; Journal article, 2022)
      Background Persons with multiple sclerosis (pwMS) have higher risk of mortality compared with the general population. Longitudinal studies are important for understanding the evolution of survival in pwMS. Objective ...
    • No association of tobacco use and disease activity in multiple sclerosis 

      Kvistad, Silje; Myhr, Kjell-Morten; Holmøy, Trygve; Saltyte Benth, Jurate; Løken-Amsrud, Kristin Ingeleiv; Wergeland, Stig; Beiske, Antonie Giæver; Bjerve, Kristian S; Hovdal, Harald Olav; Lilleås, Finn; Midgard, Rune; Pedersen, Tom; Bakke, Søren Jacob; Torkildsen, Øivind (Journal article; Peer reviewed, 2016)
      Objective: To study whether tobacco use is associated with MRI and clinical disease activity in patients with multiple sclerosis (MS). Methods: Prospective cohort study of 87 patients with relapsing-remitting MS originally ...
    • Nye sentre skal gi flere kliniske studier i Norge 

      Skoie, Inger Marie; Skogås, Jan Gunnar; Langø, Thomas; Myhr, Kjell-Morten; Myhre, Peder Langeland; Goll, Rasmus; Fretland, Signe Øien; Helland, Åslaug (Journal article; Peer reviewed, 2023)
      Seks NorTrials-sentre for behandlingsforskning er etablert ved universitetssykehusene. Målet er å øke antallet kliniske studier og forbedre pasientbehandlingen.
    • Perinatal Depression and Anxiety in Women with Multiple Sclerosis: A Population-Based Cohort Study 

      Eid, Karine; Torkildsen, Øivind Fredvik Grytten; Aarseth, Jan Harald; Flemmen, Heidi Øyen; Holmøy, Trygve; Lorentzen, Åslaug Rudjord; Myhr, Kjell-Morten; Riise, Trond; Simonsen, Cecilia Smith; Torkildsen, Cecilie Fredvik; Wergeland, Stig; Willumsen, Johannes Sverre; Øksendal, Nina; Gilhus, Nils Erik; Bjørk, Marte-Helene (Journal article; Peer reviewed, 2021)
      Objective: To assess the occurrence of perinatal depression and anxiety in women before and after diagnosis of multiple sclerosis (MS). Methods: 114,629 pregnant women were included in the Norwegian Mother, Father and Child ...
    • Risk of cancer among multiple sclerosis patients, siblings, and population controls: A prospective cohort study 

      Grytten, Nina; Myhr, Kjell-Morten; Celius, Elisabeth Gulowsen; Benjaminsen, Espen; Kampman, Margitta Theodora; Midgard, Rune; Vatne, Anita; Aarseth, Jan Harald; Riise, Trond; Torkildsen, Øivind (Journal article; Peer reviewed, 2019)
      Background: Risk of cancer in multiple sclerosis (MS) patients compared to their siblings is unknown. Objective: The objective was to prospectively investigate the risk of cancer among MS patients compared to siblings ...
    • Serum neurofilament as a predictor of 10-year grey matter atrophy and clinical disability in multiple sclerosis: a longitudinal study 

      Lie, Ingrid Anne; Kacar, Sezgi; Wesnes, Kristin; Brouwer, Iman; Kvistad, Silje S.; Wergeland, Stig; Holmøy, Trygve; Midgard, Rune; Bru, Alla Nikolajevna S; Edland, Astrid; Eikeland, Randi; Gosal, Sonia; Harbo, Hanne-Cathrin Flinstad; Kleveland, Grethe; Sørenes, Yvonne; Øksendal, Nina; Varhaug, Kristin Nielsen; Vedeler, Christian Alexander; Barkhof, Frederik; Teunissen, Charlotte E.; Bø, Lars; Torkildsen, Øivind Fredvik Grytten; Myhr, Kjell-Morten; Vrenken, Hugo (Peer reviewed; Journal article, 2022)
      Background - The predictive value of serum neurofilament light chain (sNfL) on long-term prognosis in multiple sclerosis (MS) is still unclear. Objective - Investigate the relation between sNfL levels over a 2-year period ...