• The effect of smoking intensity on all-cause and cause-specific mortality-a Mendelian randomization analysis. 

      Vie, Gunnhild Åberge; Wootton, Robyn E; Bjørngaard, Johan Håkon; Åsvold, Bjørn Olav; Taylor, AE; Gabrielsen, Maiken Elvestad; Davey, George Smith; Romundstad, Pål Richard; Munafo, Marcus R (Peer reviewed; Journal article, 2019)
      Background Smoking is an important cause of mortality and recent studies have suggested that even low-intensity smoking might be associated with increased mortality. Still, smoking is associated with lower socio-economic ...
    • Heavier smoking increases coffee consumption: findings from a Mendelian randomization analysis 

      Bjørngaard, Johan Håkon; Nordestgaard, AT; Taylor, Amy E; Treur, Jorien L; Gabrielsen, Maiken Elvestad; Munafo, Marcus R; Nordestgaard, BG; Åsvold, Bjørn Olav; Romundstad, Pål Richard; Davey Smith, George (Journal article; Peer reviewed, 2017)
      Background There is evidence for a positive relationship between cigarette and coffee consumption in smokers. Cigarette smoke increases metabolism of caffeine, so this may represent a causal effect of smoking on caffeine ...
    • Investigating the possible causal association of smoking with depression and anxiety using Mendelian randomisation meta-analysis: the CARTA consortium 

      Taylor, Amy E; Fluharty, Meg; Bjørngaard, Johan Håkon; Gabrielsen, Maiken Elvestad; Skorpen, Frank; Marioni, Riccardo R.; Campbell, A.; Engmann, J; Mirza, Saira Saeed; Loukola, A.; Laatikainen, Tiina; Partonen, Timo; Kaakinen, Marika; Ducci, Francesca; Cavadino, Alana; Husemoen, Lise Lotte N; Ahluwalia, Tarunveer Singh; Jacobsen, Rikke Kart; Skaaby, Tea; Ebstrup, Jeanette Frost; Mortensen, Erik Lykke; Minica, Camelia C; Vink, Jacqueline; Willemsen, Gonneke; Marques-Vidal, Pedro; Dale, Caroline E; Amuzu, Antoinette; Lennon, Lucy; Lahti, J; Palotie, Aarno; Räikkönen, K; Wong, Andrew; Paternoster, Lavinia; Wong, Angelita Pui-Yee; Horwood, L John; Murphy, Michael; Johnstone, Elaine; Kennedy, Martin A; Pausova, Zdenka; Paus, Tomas; Ben-Shlomo, Yoav; Nohr, Ellen A; Kuh, Diana; Kivimaki, Mika; Eriksson, Johan G; Morris, Richard W; Casas, Juan Pablo; Preisig, Martin; Boomsma, Dorret I; Linneberg, Allan; Power, Chris; Hypponen, Elina; Veijola, J; Järvelin, Marjo-Riitta; Korhonen, T.; Tiemeier, H; Kumari, Meena; Porteous, David J.; Hayward, Caroline; Romundstad, Pål Richard; Smith, George Davey; Munafo, Marcus R (Journal article; Peer reviewed, 2014)
      Objectives: To investigate whether associations of smoking with depression and anxiety are likely to be causal, using a Mendelian randomisation approach. Design: Mendelian randomisation meta-analyses using a genetic ...
    • Is disrupted sleep a risk factor for Alzheimer's disease? Evidence from a two-sample Mendelian randomization analysis 

      Anderson, Emma L.; Richmond, Rebecca C.; Jones, Samuel E.; Hemani, Gibran; Wade, Kaitlin H; Dashti, Hassan S.; Lane, Jaqueline; Wang, Heming; Saxena, Richa; Brumpton, Ben Michael; Korologou-Linden, Roxanna; Nielsen, Jonas Bille; Åsvold, Bjørn Olav; Abecasis, Goncalo; Coulthard, Elizabeth; Kyle, Simon D.; Beaumont, Robin N.; Tyrell, Jessica; Frayling, Timothy M; Munafo, Marcus R; Wood, Andrew R; Ben-Shlomo, Yoav; Howe, Laura D; Lawlor, Deborah A.; Weedon, Michael N; Smith, George Davey (Peer reviewed; Journal article, 2020)
      Background It is established that Alzheimer’s disease (AD) patients experience sleep disruption. However, it remains unknown whether disruption in the quantity, quality or timing of sleep is a risk factor for the onset ...
    • Maternal Smoking in Pregnancy and Offspring Depression: A cross cohort and negative control study 

      Taylor, Amy E; Carslake, David; De Mola, Christian Loret; Rydell, Mina; Nilsen, Tom Ivar Lund; Bjørngaard, Johan Håkon; Horta, Bernardo Lessa; Pearson, Rebecca; Rai, Dheeraj; Galanti, Maria Rosaria; Barros, Fernando C.; Romundstad, Pål Richard; Davey Smith, George; Munafo, Marcus R (Journal article; Peer reviewed, 2017)
      Previous reports suggest that offspring of mothers who smoke during pregnancy have greater risk of developing depression. However, it is unclear whether this is due to intrauterine effects. Using data from the Avon ...
    • Stratification by smoking status reveals an association of CHRNA5-A3-B4 genotype with body mass index in never smokers 

      Taylor, Amy E; Morris, Richard W; Fluharty, Meg; Bjørngaard, Johan Håkon; Åsvold, Bjørn Olav; Gabrielsen, Maiken Elvestad; Campbell, A.; Marioni, Riccardo R.; Kumari, Meena; Hällfors, Jenni; Männistö, Satu; Marques-Vidal, Pedro; Kaakinen, Marika; Cavadino, Alana; Postmus, Iris; Husemoen, Lise Lotte N; Skaaby, Tea; Ahluwalia, Tarunveer Singh; Treur, Jorien L; Willemsen, Gonneke; Dale, Caroline; Wannamethee, SG; Lahti, J; Palotie, Aarno; Räikkönen, K; Kisialiou, Aliaksei; McConnachie, Alex; Padmanabhan, Sandosh; Wong, Andrew; Dalgård, Christine; Paternoster, Lavinia; Ben-Shlomo, Yoav; Tyrrell, Jessica; Horwood, John; Fergusson, D; Kennedy, Martin A; Frayling, T; Nohr, Ellen A; Christiansen, Lene; Ohm Kyvik, K; Kuh, Diana; Watt, Graham; Eriksson, Johan; Whincup, Peter H; Vink, JM; Boomsma, Dorret I; Davey Smith, George; Lawlor, Debbie A; Linneberg, Allan; Ford, Ian; Jukema, J Wouter; Power, C; Hyppönen, E; Jarvelin, Marjo-Riitta; Preisig, Martin; Borodulin, Katja; Kaprio, Jaakko; Kivimaki, Mika; Smith, BH; Hayward, Caroline; Romundstad, Pål Richard; Sørensen, Thorkild I.A.; Munafo, Marcus R; Sattar, Naveed (Journal article; Peer reviewed, 2014)
      We previously used a single nucleotide polymorphism (SNP) in the CHRNA5-A3-B4 gene cluster associated with heaviness of smoking within smokers to confirm the causal effect of smoking in reducing body mass index (BMI) in a ...