• A small molecule activator of AKT does not reduce ischemic injury of the rat heart 

      Moreira, Jose Bianco Nascimento; Wohlwend, Martin; Alves, Marcia Netto Magalhaes; Wisløff, Ulrik; Bye, Anja (Journal article; Peer reviewed, 2015)
      Background Activation of protein kinase AKT is required for cardioprotection by ischemic preconditioning, and transgenic overexpression of AKT protects the heart against ischemia. However, it is unknown whether acute ...
    • Are the Neuroprotective Effects of Exercise Training Systemically Mediated? 

      Tari, Atefe R; Norevik, Cecilie Skarstad; Scrimgeour, Nathan Robert; Kobro-Flatmoen, Asgeir; Storm-Mathisen, Jon; Bergersen, Linda Hildegard; Wrann, Christiane D; Selbæk, Geir; Kivipelt, Miia; Moreira, Jose Bianco Nascimento; Wisloff, Ulrik (Journal article; Peer reviewed, 2019)
      To date there is no cure available for dementia, and the field calls for novel therapeutic targets. A rapidly growing body of literature suggests that regular endurance training and high cardiorespiratory fitness attenuate ...
    • Autophagy signaling in skeletal muscle of infarcted rats 

      Jannig, Paulo R.; Moreira, Jose Bianco Nascimento; Bechara, Luiz R.G.; Bozi, Luiz H.M.; Bacurau, Aline V.; Monteiro, Alex W.A.; Dourado, Paulo M.; Wisløff, Ulrik; Brum, Patricia Chakur (Journal article; Peer reviewed, 2014)
      Background: Heart failure (HF)-induced skeletal muscle atrophy is often associated to exercise intolerance and poor prognosis. Better understanding of the molecular mechanisms underlying HF-induced muscle atrophy may ...
    • Deletion of Kinin B2 receptor alters muscle metabolism and exercise performance 

      Reis, Felipe CG; Haro, Anderson S; Bacurau, Aline V.; Hirabara, Sandro M; Wasinski, Frederick; Ormanji, Milene S; Moreira, Jose Bianco Nascimento; Kiyomoto, Beatriz H; Bertoncini, Clelia RA; Brum, Patricia Chakur; Curi, Rui; Bader, Michael; Bacurau, Reury FP; Pesquero, Joao B; Araujo, Ronaldo C (Journal article, 2015)
      Metabolic syndrome is a cluster of metabolic risk factors such as obesity, diabetes and cardiovascular diseases. Mitochondria is the main site of ATP production and its dysfunction leads to decreased oxidative phosphorylation, ...
    • Differential regulation of cysteine oxidative post-translational modifications in high and low aerobic capacity 

      Souza, Rodrigo W. A.; Alves, Christiano R. R.; Medeiros, Alessandra; Rolim, Natale Pinheiro Lage; Silva, Gustavo Jose Justo; Moreira, Jose Bianco Nascimento; Alves, Marcia Netto Magalhaes; Wohlwend, Martin; Gebriel, Mohammed; Hagen, Lars; Sharma, Animesh; Koch, Lauren G.; Britton, Steven L.; Slupphaug, Geir; Wisløff, Ulrik; Brum, Patricia C. (Journal article; Peer reviewed, 2018)
      Given the association between high aerobic capacity and the prevention of metabolic diseases, elucidating the mechanisms by which high aerobic capacity regulates whole-body metabolic homeostasis is a major research challenge. ...
    • Exercise prevents impaired autophagy and proteostasis in a model of neurogenic myopathy 

      Campos, Juliane C; Baehr, Leslie M; Gomes, Katia M S; Bechara, Luiz R.G.; Voltarelli, Vanessa; Bozi, Luiz H.M.; Ribeiro, Marcio AC; Ferreira, Nikolas D; Moreira, Jose Bianco Nascimento; Brum, Patricia C.; Bodine, Sue C; Ferreira, Julio CB (Journal article; Peer reviewed, 2018)
      Increased proteolytic activity has been widely associated with skeletal muscle atrophy. However, elevated proteolysis is also critical for the maintenance of cellular homeostasis by disposing cytotoxic proteins and ...
    • Therapeutic Targeting of Cardiac PI3K-AKT Signaling 

      Moreira, Jose Bianco Nascimento (Doctoral thesis at NTNU;2015:83, Doctoral thesis, 2015)
      Therapeutic Targeting of Cardiac PI3K-AKT Signaling: Cardiac diseases (CVD) are by far the main cause of death in humans and the prognosis for cardiac patients remains unacceptably poor, which calls for development of ...