Browsing NTNU Open by Author "Mohlin, Camilla"
Now showing items 1-3 of 3
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Combined blockade of complement C5 and TLR co-receptor CD14 synergistically inhibits pig-to-human corneal xenograft induced innate inflammatory responses
Islam, Rakibul; Islam, Mohammad Mirazul; Nilsson, Per H.; Mohlin, Camilla; Hagen, Kjersti Thorvaldsen; Paschalis, Eleftherios I.; Woods, Russell L.; Bhowmick, Sabuj Chandra; Dohlman, Claes H.; Espevik, Terje; Chodosh, James; Gonzalez-Andrades, Miguel; Mollnes, Tom Eirik (Peer reviewed; Journal article, 2021)Inadequate supplies of donor corneas have evoked an escalating interest in corneal xenotransplantation. However, innate immune responses contribute significantly to the mechanism of xenograft rejection. We hypothesized ... -
Heme Interferes With Complement Factor I-Dependent Regulation by Enhancing Alternative Pathway Activation
Gerogianni, Alexandra; Dimitrov, Jordan D.; Zarantonello, Alessandra; Poillerat, Victoria; Chonat, Satheesh; Sandholm, Kerstin; McAdam, Karin E.; Ekdahl, Kristina N.; Mollnes, Tom Eirik; Mohlin, Camilla; Roumenina, Lubka T.; Nilsson, Per (Peer reviewed; Journal article, 2022)Hemolysis, as a result of disease or exposure to biomaterials, is characterized by excess amounts of cell-free heme intravascularly and consumption of the protective heme-scavenger proteins in plasma. The liberation of ... -
In vitro evaluation of iron oxide nanoparticle-induced thromboinflammatory response using a combined human whole blood and endothelial cell model
Gerogianni, Alexandra; Bal, Melissa; Mohlin, Camilla; Woodruff, Trent M.; Lambris, John D.; Mollnes, Tom Eirik; Sjöström, Dick J.; Nilsson, Per (Peer reviewed; Journal article, 2023)Iron oxide nanoparticles (IONPs) are widely used in diagnostic and therapeutic settings. Upon systemic administration, however, they are rapidly recognized by components of innate immunity, which limit their therapeutic ...