Blar i NTNU Open på forfatter "Moen, Ingrid Nyhus"
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Characterization of birinapant-induced cell death in human monocytes and macrophage subtypes
Klaharn, Merisa (Master thesis, 2019)Macrophages play various roles in the body depending on the environment they reside due to their diversity and plasticity. Distinct functional phenotypes operate specific tasks, ranging from inflammation and host defense ... -
Pharmaceutical targeting of RIPK1-signaling: Characterization of cell death in human macrophage systems and therapeutic potential in multiple myeloma
Moen, Ingrid Nyhus (Doktoravhandlingar ved NTNU;2021:411, Doctoral thesis, 2021)The receptor-interacting protein kinase 1 (RIPK1)-pathway is a key regulator of inflammation and cell death. RIPK1-dependent cell death has been well studied in murine macrophages but as it is context dependent and differently ... -
SMAC-mimetic induced cell death in LPS-pretreated human macrophages
Holter-Sørensen, Marie Namtvedt (Master thesis, 2021)Betennelse er en biologisk respons i kroppsvevet forårsaket av skadelig stimuli. For å opprettholde homeostase i kroppen er det viktig å nøye regulere immuncellene. Dysregulert aktivitet av en immuncelletype som heter ... -
Smac-mimetics reduce numbers and viability of human osteoclasts
Moen, Ingrid Nyhus; Westhrin, Marita; Håland, Erling; Haug, Markus; Nonstad, Unni; Klaharn, Merisa; Standal, Therese; Starheim, Kristian K. (Peer reviewed; Journal article, 2021)Elevated activity of bone-degrading osteoclasts (OC) contributes to pathological bone degradation in diseases such as multiple myeloma. Several proinflammatory cytokines, including TNF, contribute to osteoclastogenesis. ...