Blar i NTNU Open på forfatter "Mjønes, Patricia"
-
Characterization of FGD5 expression in primary breast cancers and lymph node metastases
Valla, Marit; Mjønes, Patricia; Engstrøm, Monica J; Ytterhus, Borgny; Bordin, Diana Lilian; van Loon, Barbara; Akslen, Lars A.; Vatten, Lars Johan; Opdahl, Signe; Bofin, Anna M. (Journal article; Peer reviewed, 2018)Faciogenital dysplasia 5 (FGD5) amplification drives tumor cell proliferation, and is present in 9.5% of breast cancers. We describe FGD5 expression, assess associations between FGD5 amplification and FGD5 expression, and ... -
Correct Identification of Cell of Origin may Explain Many Aspects of Cancer: The role of Neuroendocrine Cells as Exemplfied from the Stomach
Waldum, Helge; Mjønes, Patricia (Peer reviewed; Journal article, 2020)Cancers are believed to originate from stem cells. Previously, the hypothesis was that tumors developed due to dedifferentiation of mature cells. We studied the regulation of gastric acid secretion and showed that gastrin ... -
The development and validation of a high-capacity serological assay for celiac disease
Klaasen, Rolf; Warren, David; Iversen, Rasmus; Bolstad, Nils; Andersen, Ina Lervåg; Mjønes, Patricia; Rønne, Elin; Lundin, Knut; Sollid, Ludvig Magne; Ness-Jensen, Eivind (Peer reviewed; Journal article, 2022)Background The aim of the present study was to develop and clinically validate a high-throughput assay for serum IgA and IgG antibodies against transglutaminase-2 (TG2) and to determine appropriate assay cut-offs for ... -
Diagnostic Accuracy in Subtyping Basal Cell Carcinoma by Clinical Diagnosis Compared with Punch Biopsy
Christensen, Eidi; Mjønes, Patricia; Grimstad, Øystein; Rørdam, Ole Martin; Foss, Olav A. (Peer reviewed; Journal article, 2016) -
Do Gastric Signet Ring Cell Carcinomas and ECL‐Cell Neuroendocrine Tumours Have a Common Origin?
Fossmark, Reidar; Johannessen, Rune; Qvigstad, Gunnar; Mjønes, Patricia (Peer reviewed; Journal article, 2022)Gastric cancer is a heterogenous group of tumours, and a better understanding of the carcinogenesis and cellular origin of the various sub-types could affect prevention and future treatment. Gastric neuroendocrine tumours ... -
Expression of erythropoietin and neuroendocrine markers in clear cell renal cell carcinoma
Mjønes, Patricia; Nordrum, Ivar Skjåk; Qvigstad, Gunnar; Sørdal, Øystein Finset; Rian, Liselotte Linnea Mårtensson; Waldum, Helge (Journal article; Peer reviewed, 2017)The aim of the study was to investigate the expression of erythropoietin and neuroendocrine markers in clear cell renal cell carcinoma (CCRCC). We retrospectively reviewed the medical records and re-evaluated histopathological ... -
Expression of the Cholecystokinin-B Receptor in Neoplastic Gastric Cells
Mjønes, Patricia; Nordrum, Ivar Skjåk; Sørdal, Øystein Finset; Sagatun, Liv; Fossmark, Reidar; Sandvik, Arne Kristian; Waldum, Helge (Journal article, 2017)Gastric cancer is an important disease due to its high mortality. Despite the decline in frequency, most cases are discovered late in its course, and most of the cancer patients die within a few years of diagnosis. In ... -
Gastric Corpus Mucosal Hyperplasia and Neuroendocrine Cell Hyperplasia, but not Spasmolytic Polypeptide-Expressing Metaplasia, Is Prevented by a Gastrin Receptor Antagonist in H+/K+ATPase Beta Subunit Knockout Mice
Aasarød, Kristin Matre; Waldum, Helge; Stunes, Astrid Kamilla; Sandvik, Arne Kristian; Flatberg, Arnar; Mjønes, Patricia; Syversen, Unni; Bakke, Ingunn; Fossmark, Reidar (Journal article; Peer reviewed, 2020)Proton pump inhibitor use is associated with an increased risk of gastric cancer, which may be mediated by hypergastrinemia. Spasmolytic polypeptide-expression metaplasia (SPEM) has been proposed as a precursor of gastric ... -
Gastrin and gastric cancer
Waldum, Helge; Sagatun, Liv; Mjønes, Patricia (Journal article; Peer reviewed, 2017)Gastric cancer although occurring in reduced frequency is still an important disease, partly because of the bad prognosis when occurring in western countries. This decline in occurrence may mainly be due to the reduced ... -
Hepatic micrometastases outside macrometastases are present in all patients with ileal neuroendocrine primary tumour at the time of liver resection.
Fossmark, Reidar; Balto, Tine Marie; Martinsen, Tom Christian; Grønbech, Jon Erik; Munkvold, Bjørn; Mjønes, Patricia; Waldum, Helge (Journal article; Peer reviewed, 2019)Background: Neuroendocrine tumours (NETs) in the ileum grow slowly but metastasise to the liver at an early stage. After resection of the primary tumour and mesenteric lymph nodes, selected patients with liver metastases ... -
Hormones and Neuroendocrine Cells, Role in Gastric and Renal Tumourigenesis
Mjønes, Patricia (Doctoral theses at NTNU;2018:111, Doctoral thesis, 2018)The role of the neuroendocrine (NE) cell in the stomach has been widely studied for decades. Particularly the enterochromaffin-like (ECL) cell and its role in carcinogenesis has been of interest (1, 2). Gastrin is found ... -
Hypergastrinemia and mortality in gastric adenocarcinoma: a population-based cohort study, the HUNT study
Ness-Jensen, Eivind; Bringeland, Erling Audun; Mjønes, Patricia; Lagergren, Jesper; Grønbech, Jon Erik; Waldum, Helge; Fossmark, Reidar (Peer reviewed; Journal article, 2022)Purpose: Hypergastrinemia increases the risk of developing proximal gastric adenocarcinoma. However, it is unclear if hypergastrinemia affects the survival in patients with gastric adenocarcinoma. This study aimed to examine ... -
Hypergastrinemia is associated with an increased risk of gastric adenocarcinoma with proximal location: A prospective population-based nested case-control study
Ness-Jensen, Eivind; Bringeland, Erling Audun; Mattsson, Fredrik; Mjønes, Patricia; Lagergren, Jesper; Grønbech, Jon Erik; Waldum, Helge; Fossmark, Reidar (Peer reviewed; Journal article, 2020)The incidence of proximal gastric adenocarcinoma is increasing among younger adults. Rodent models have shown that hypergastrinemia causes carcinogenesis in the proximal stomach. The aim of our study was therefore to assess ... -
Is there a relationship between the stratum corneum thickness and that of the viable parts of tumour cells in basal cell carcinoma?
Foss, Olav A.; Mjønes, Patricia; Fismen, Silje; Christensen, Eidi (Journal article; Peer reviewed, 2016)Basal cell carcinoma (BCC) is an invasive epithelial skin tumour. The thickness of the outermost epidermal layer of the skin, the stratum corneum (SC), influences drug uptake and penetration into tumour and may thereby ... -
Meningiomas and Somatostatin Analogs: A Systematic Scoping Review on Current Insights and Future Perspectives
Tollefsen, Sofie Eline (Master thesis, 2023)Bakgrunn. Meningeomer er den hyppigst forekommende hjernesvulsten, og insidensen er økende. Selv om de fleste meningeomer er godartede og saktevoksende er residivraten betydelig. Dagens behandlingsvalg bestående av kirurgi ... -
Neuron-Specific Enolase as an Immunohistochemical Marker Is Better Than Its Reputation
Mjønes, Patricia; Sagatun, Liv; Nordrum, Ivar Skjåk; Waldum, Helge (Journal article; Peer reviewed, 2017)The diagnosis of neuroendocrine neoplasms (NENs) may be challenging and is based on typical morphological features and positive staining for antibodies of neuroendocrine differentiation. Neuron-specific enolase (NSE) being ... -
Not only stem cells, but also mature cells, particularly neuroendocrine cells, may develop into tumours: time for a paradigm shift
Waldum, Helge; Öberg, Kjell; Sørdal, Øystein Finset; Sandvik, Arne Kristian; Gustafsson, Björn; Mjønes, Patricia; Fossmark, Reidar (Journal article; Peer reviewed, 2018)Stem cells are considered the origin of neoplasms in general, and malignant tumours in particular, and the stage at which the stem cells stop their differentiation determines the degree of malignancy. However, there is ... -
Secretagogin – a new biomarker for neuroendocrine growth mechanisms in humane meningiomas?
Nguyen, Teresa Thao Tram (Master thesis, 2022)Bakgrunn: Meningeomer står for en tredjedel av alle intrakranielle tumorer hos voksne, noe som gjør det til den vanligste hjernesvulsten. De oppstår fra hjernehinnene. De fleste er benigne og vokser sakte, men de kan likevel ... -
Survival and disease recurrence in patients operated for small intestinal neuroendocrine tumors at a referral hospital.
Folkestad, Oddry H; Wasmuth, Hans; Mjønes, Patricia; Fougner, Reidun; Hauso, Øyvind; Fossmark, Reidar (Peer reviewed; Journal article, 2020)Background and objectives Small intestinal neuroendocrine tumors (SI-NETs) are slow growing but have frequently metastasized at the time of diagnosis. Most patients are operated with either curative intent or with intent ... -
Survival and disease recurrence in patients with duodenal neuroendocrine tumours—a single centre cohort
Folkestad, Oddry; Wasmuth, Hans; Mjønes, Patricia; Fougner, Reidun; Hauso, Øyvind; Fossmark, Reidar (Journal article; Peer reviewed, 2021)Background: Duodenal neuroendocrine tumours (D-NETs) are rare but increasingly diagnosed. This study aimed to assess the overall survival and recurrence rate among patients treated for D-NETs. Methods: Patients with D-NETs ...