Blar i NTNU Open på forfatter "Meltzer, Sebastian"

Viser treff 1-20 av 22

    • An experimental strategy unveiling exosomal microRNAs 486-5p, 181a-5p and 30d-5p from hypoxic tumour cells as circulating indicators of high-risk rectal cancer 

      Bjørnetrø, Tonje; Redalen, Kathrine; Meltzer, Sebastian; Thusyanthan, Nirujah Sivarajah; Samiappan, Rampradeep; Jegershöld, Caroline; Handeland, Karianne Risberg; Ree, Anne Hansen (Journal article; Peer reviewed, 2019)
      Tumour hypoxia contributes to poor treatment outcome in locally advanced rectal cancer (LARC) and circulating extracellular vesicles (EVs) as potential biomarkers of tumour hypoxia and adverse prognosis have not been fully ...

    • Circulating Exosomal miR-141-3p and miR-375 in Metastatic Progression of Rectal Cancer 

      Meltzer, Sebastian; Bjørnetrø, Tonje; Lyckander, Lars Gustav; Flatmark, Kjersti; Dueland, Svein; Samiappan, Rampradeep; Johansen, Christin; Kalanxhi, Ert; Ree, Anne Hansen; Redalen, Kathrine (Journal article; Peer reviewed, 2019)
      As many as 30% to 40% of locally advanced rectal cancer (LARC) patients experience metastatic progression of the disease. Recognizing the potential of the genetic cargo in tumor-derived exosomes, we hypothesized that plasma ...

    • The circulating soluble form of the CD40 costimulatory immune checkpoint receptor and liver metastasis risk in rectal cancer 

      Meltzer, Sebastian; Kristensen, Annette Torgunrud; Abrahamsson, Hanna Josefine; Solbakken, Arne Mide; Flatmark, Kjersti; Dueland, Svein; Bakke, Kine Mari; Bousquet, Paula; Negård, Anne; Johansen, Christin; Lyckander, Lars Gustav; Larsen, Finn Ole; Schou, Jakob Vasehus; Redalen, Kathrine; Ree, Anne Hansen (Peer reviewed; Journal article, 2021)
      Background In colorectal cancer, the inflamed tumour microenvironment with its angiogenic activities is immune- tolerant and incites progression to liver metastasis. We hypothesised that angiogenic and inflammatory factors ...

    • Comparison of Intravoxel incoherent motion imaging and multiecho dynamic contrast-based MRI in rectal cancer 

      Bakke, Kine Mari; Grøvik, Endre; Meltzer, Sebastian; Negård, Anne; Holmedal, Stein Harald; Mikalsen, Lars Tore G; Lyckander, Lars Gustav; Ree, Anne Hansen; Gjesdal, Kjell-Inge; Redalen, Kathrine; Bjørnerud, Atle (Journal article; Peer reviewed, 2019)
      Background Dynamic contrast‐based MRI and intravoxel incoherent motion imaging (IVIM) MRI are both methods showing promise as diagnostic and prognostic tools in rectal cancer. Both methods aim at measuring perfusion‐related ...

    • Corrigendum to “Circulating exosomal miR-141-3p and miR-375 in metastatic progression of rectal cancer” [Transl Oncol 12 (8) (2019) 1038-1044] 

      Meltzer, Sebastian; Bjørnetrø, Tonje; Lyckander, Lars Gustav; Flatmark, Kjersti; Dueland, Svein; Samiappan, Rampradeep; Johansen, Christin; Kalanxhi, Erta; Ree, Anne Hansen; Redalen, Kathrine (Peer reviewed; Journal article, 2020)

    • Early radiologic signal of responsiveness to immune checkpoint blockade in microsatellite-stable/mismatch repair-proficient metastatic colorectal cancer 

      Meltzer, Sebastian; Negård, Anne; Bakke, Kine Mari; Hamre, Hanne Mari; Kersten, Christian; Hofsli, Eva; Guren, Marianne; Sorbye, Halfdan; Flatmark, Kjersti; Ree, Anne Hansen (Journal article; Peer reviewed, 2022)

    • Energy Metabolism Is Altered in Radioresistant Rectal Cancer 

      Buckley, Croí E.; Yin, Xiaofei; Meltzer, Sebastian; Ree, Anne Hansen; Redalen, Kathrine Røe; Brennan, Lorraine; O’Sullivan, Jacintha; Lynam-Lennon, Niamh (Peer reviewed; Journal article, 2023)
      Resistance to neoadjuvant chemoradiation therapy is a significant clinical challenge in the management of rectal cancer. There is an unmet need to identify the underlying mechanisms of treatment resistance to enable the ...

    • First-line oxaliplatin-based chemotherapy and nivolumab for metastatic microsatellite-stable colorectal cancer—the randomised METIMMOX trial 

      Ree, Anne Hansen; Saltyte Benth, Jurate; Hamre, Hanne Mari; Kersten, Christian; Hofsli, Eva; Guren, Marianne; Sorbye, Halfdan; Johansen, Christin; Negård, Anne; Bjørnetrø, Tonje; Nilsen, Hilde; Berg, Jens Petter; Flatmark, Kjersti; Meltzer, Sebastian (Journal article; Peer reviewed, 2024)
      Background We evaluated first-line treatment of metastatic microsatellite-stable colorectal cancer with short-course oxaliplatin-based chemotherapy alternating with immune checkpoint blockade. Methods Patients were ...

    • Hever kvaliteten på behandling av kreft 

      Helland, Åslaug; Steinskog, Eli Sihn Samdal; Blix, Egil St⊘re; Flobak, Åsmund; Brabrand, Sigmund; Puco, Katarina; Niehusmann, Pitt; Meltzer, Sebastian; Oppedal, Irja Alida; Haug, Åse; Blix, Egil Støre; Torkildsen, Cecilie Fredvik; Randen, Ulla; Gilje, Bj⊘rnar; Gilje, Bjørnar; L⊘nning, Per Eystein; Lønning, Per Eystein; Gjertsen, Bjørn Tore; Hovland, Randi; Russnes, Hege Elisabeth Giercksky; Fagereng, Gro Live; Smeland, Sigbjørn; Tasken, Kjetil (Journal article; Peer reviewed, 2024)

    • High level of circulating vitamin D during neoadjuvant therapy may lower risk of metastatic progression in high-risk rectal cancer 

      Abrahamsson, Hanna Josefine; Porojnicu, Alina Carmen; Lindstrøm, Jonas Christoffer; Dueland, Svein; Flatmark, Kjersti; Hole, Knut Håkon; Seierstad, Therese; Moan, Johan Emilian; Redalen, Kathrine; Meltzer, Sebastian; Ree, Anne Hansen (Journal article; Peer reviewed, 2019)
      Background:Following curative-intent neoadjuvant therapy in locally advanced rectal cancer, metastaticprogression is still dominant. We investigated if patients’circulating 25-hydroxyvitamin D [25(OH)D] levels wereassociated ...

    • High level of circulating vitamin D during neoadjuvant therapy may lower risk of metastatic progression in high-risk rectal cancer 

      Abrahamsson, Hanna Josefine; Porojnicu, Alina Carmen; Lindstrøm, Jonas Christoffer; Dueland, Svein; Flatmark, Kjersti; Hole, Knut Håkon; Seierstad, Therese; Moan, Johan Emilian; Redalen, Kathrine Røe; Meltzer, Sebastian; Ree, Anne Hansen (Journal article; Peer reviewed, 2019)
      Background: Following curative-intent neoadjuvant therapy in locally advanced rectal cancer, metastatic progression is still dominant. We investigated if patients’ circulating 25-hydroxyvitamin D [25(OH)D] levels were ...

    • Imaging the tumour microenvironment in rectal cancer: Decline in tumour blood flow during radiotherapy predicts good outcome 

      Bakke, Kine Mari; Meltzer, Sebastian; Grøvik, Endre; Negård, Anne; Holmedal, Stein Harald; Mikalsen, Lars Tore Gyland; Færden, Arne Engebreth; Lyckander, Lars Gustav; Julbø, Frida Marie Ihle; Bjørnerud, Atle; Gjesdal, Kjell Inge; Ree, Anne Hansen; Redalen, Kathrine Røe (Peer reviewed; Journal article, 2023)
      Background and purpose Measuring rectal tumour response to radiation is pivotal to restaging patients and for possibly stratification to a watch-and-wait strategy. Recognizing the importance of the tumour microenvironment, ...

    • Immunogenic cell death by neoadjuvant oxaliplatin and radiation protects against metastatic failure in high-risk rectal cancer. 

      Bains, Simer Jit; Abrahamsson, Hanna Josefine; Flatmark, Kjersti; Dueland, Svein; Hole, Knut Håkon; Seierstad, Therese; Redalen, Kathrine; Meltzer, Sebastian; Ree, Anne Hansen (Journal article; Peer reviewed, 2019)
      Objective High rates of systemic failure in locally advanced rectal cancer call for a rational use of conventional therapies to foster tumor-defeating immunity. Methods We analyzed the high-mobility group box-1 ...

    • Markers of mitochondrial metabolism in tumor hypoxia, systemic inflammation, and adverse outcome of rectal cancer 

      Bousquet, Paula; Meltzer, Sebastian; Sønstevold, Linda; Esbensen, Qin Ying; Dueland, Svein; Flatmark, Kjersti; Sitter, Beathe; Bathen, Tone Frost; Seierstad, Therese; Redalen, Kathrine; Eide, Lars; Ree, Anne Hansen (Journal article; Peer reviewed, 2019)
      Tumor hypoxia contributes to therapy resistance and metastatic progression of locally advanced rectal cancer (LARC). We postulated that the tumor mitochondrial metabolism, manifested by reactive oxygen species (ROS) and ...

    • MRI-based automatic segmentation of rectal cancer using 2D U-Net on two independent cohorts 

      Knuth, Franziska Hanna; Adde, Ingvild Askim; Huynh, Bao Ngoc; Grøndahl, Aurora Rosvoll; Winter, René; Negård, Anne; Holmedal, Stein Harald; Meltzer, Sebastian; Ree, Anne Hansen; Flatmark, Kjersti; Dueland, Svein; Hole, Knut Håkon; Seierstad, Therese; Redalen, Kathrine; Futsæther, Cecilia Marie (Peer reviewed; Journal article, 2021)
      Background Tumor delineation is time- and labor-intensive and prone to inter- and intraobserver variations. Magnetic resonance imaging (MRI) provides good soft tissue contrast, and functional MRI captures tissue properties ...

    • MRI-based automatic segmentation of rectal cancer using 2D U-Net on two independent cohorts 

      Knuth, Franziska Hanna; Adde, Ingvild Askim; Huynh, Bao Ngoc; Groendahl, Aurora Rosvoll; Winter, René Mario; Negård, Anne; Holmedal, Stein Harald; Meltzer, Sebastian; Ree, Anne Hansen; Flatmark, Kjersti; Dueland, Svein; Hole, Knut Håkon; Seierstad, Therese; Redalen, Kathrine Røe; Futsaether, Cecilie Maria (Peer reviewed; Journal article, 2022)
      Background: Tumor delineation is time- and labor-intensive and prone to inter- and intraobserver variations. Magnetic resonance imaging (MRI) provides good soft tissue contrast, and functional MRI captures tissue properties ...

    • Next-generation sequencing reveals mitogenome diversity in plasma extracellular vesicles from colorectal cancer patients 

      Bjørnetrø, Tonje; Bousquet, Paula; Redalen, Kathrine Røe; Siebke, Anne-Marie; Lüders, Torben; Stang, Espen; Sanabria-Moreno, Adriana Maria; Johansen, Christin; Fuglestad, Anniken Jørlo; Kersten, Christian; Meltzer, Sebastian; Ree, Anne Hansen (Peer reviewed; Journal article, 2023)
      Background Recent reports have demonstrated that the entire mitochondrial genome can be secreted in extracellular vesicles (EVs), but the biological attributes of this cell-free mitochondrial DNA (mtDNA) remain ...

    • Semi-automatic tumor segmentation of rectal cancer based on functional magnetic resonance imaging 

      Knuth, Franziska Hanna; Grøndahl, Aurora Rosvoll; Winter, René; Torheim, Turid Katrine Gjerstad; Negård, Anne; Holmedal, Stein Harald; Bakke, Kine Mari; Meltzer, Sebastian; Futsæther, Cecilia Marie; Redalen, Kathrine (Peer reviewed; Journal article, 2022)
      Background and purpose Tumor delineation is required both for radiotherapy planning and quantitative imaging biomarker purposes. It is a manual, time- and labor-intensive process prone to inter- and intraobserver ...

    • Sex differences and tumor blood flow from dynamic susceptibility contrast MRI are associated with treatment response after chemoradiation and long-term survival in rectal cancer 

      Bakke, Kine Mari; Meltzer, Sebastian; Grøvik, Endre; Negård, Anne; Holmedal, Stein Harald; Gjesdal, Kjell-Inge; Bjørnerud, Atle; Ree, Anne Hansen; Redalen, Kathrine (Peer reviewed; Journal article, 2020)
      Sex differences, tumor vascularity, and blood flow seen on multiecho dynamic contrast–based MRI scans enabled prediction of treatment response and overall survival in patients with rectal cancer. Background: MRI is the ...

    • Sex disparities in vitamin D status and the impact on systemic inflammation and survival in rectal cancer 

      Abrahamsson, Hanna Josefine; Meltzer, Sebastian; Hagen, Vidar Nyløkken; Johansen, Christin; Bousquet, Paula; Redalen, Kathrine; Ree, Anne Hansen (Peer reviewed; Journal article, 2021)
      Background We reported previously that rectal cancer patients given curative-intent chemotherapy, radiation, and surgery for non-metastatic disease had enhanced risk of metastatic progression and death if circulating ...