• E-cadherin cleavage by MT2-MMP regulates apical junctional signaling and epithelial homeostasis in the intestine 

      Gómez-Escudero, Jesús; Moreno, Vanessa; Martín-Alonso, Mara; Hernández de Riquer, M. Victoria; Feinberg, Tamar; Colmenar, Ángel; Calvo, Enrique; Camafeita, Emilio; Martínez, Fernando; J. Weiss, Stephen; Arroyo, Alicia G.; J. Oudhoff, Menno (Journal article; Peer reviewed, 2017)
      Cadherin-based intercellular adhesions are essential players in epithelial homeostasis, but their dynamic regulation during tissue morphogenesis and remodeling remain largely undefined. Herein, we characterize an unexpected ...
    • LSD1 represses a neonatal/reparative gene program in adult intestinal epithelium 

      Zwiggelaar, Rosalie; Lindholm, Håvard Takle; Fosslie, Madeleine Lystad; Pedersen, Marianne Terndrup; Ohta, Yuki; Díez-Sánchez, Alberto; Martín-Alonso, Mara; Ostrop, Jenny; Matono, Mami; Parmar, Naveen; Kvaløy, Emilie; Spanjers, Roos; Nazmi, Kamran; Rye, Morten Beck; Drabløs, Finn; Arrowsmith, Cheryl H; Dahl, John Arne; Jensen, Kim B.; Sato, Toshiro; Oudhoff, Menno (Journal article; Peer reviewed, 2020)
      Intestinal epithelial homeostasis is maintained by adult intestinal stem cells, which, alongside Paneth cells, appear after birth in the neonatal period. We aimed to identify regulators of neonatal intestinal epithelial ...