Browsing NTNU Open by Author "Malik, Rainer"

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    • Common Genetic Variation Indicates Separate Causes for Periventricular and Deep White Matter Hyperintensities 

      Armstrong, Nicola J; Mather, Karen A.; Sargurupremraj, Muralidharan; Knol, Maria J.; Malik, Rainer; Satizabal, Claudia L.; Yanek, Lisa R.; Wen, Wei; Gudnason, Vilmundur G.; Dueker, Nicole D.; Elliott, Lloyd T.; Hofer, Edith; Håberg, Asta; Jahanshad, Neda; Nyquist, Paul A. (Journal article; Peer reviewed, 2020)

    • Genome-wide analysis of 102,084 migraine cases identifies 123 risk loci and subtype-specific risk alleles 

      Hautakangas, Heidi; Winsvold, Bendik K S; Ruotsalainen, Sanni; Bjornsdottir, Gyda; Harder, Aster V. E.; Kogelman, Lisette J. A.; Thomas, Laurent; Noordam, Raymond; Benner, Christian; Gormley, Padhraig; Artto, Ville; Banasik, Karina; Bjornsdottir, Anna; Boomsma, Dorret I.; Brumpton, Ben Michael; Burgdorf, Kristoffer Sølvsten; Buring, Julie E.; Chalmer, Mona Ameri; de Boer, Irene; Dichgans, Martin; Erikstrup, Christian; Färkkilä, Markus; Gabrielsen, Maiken Elvestad; Ghanbari, Mohsen; Hagen, Knut; Häppölä, Paavo; Hottenga, Jouke-Jan; Hrafnsdottir, Maria G.; Hveem, Kristian; Johnsen, Marianne Bakke; Kähönen, Mika; Kristoffersen, Espen Saxhaug; Kurth, Tobias; Lehtimäki, Terho; Lighart, Lannie; Magnusson, Sigurdur H.; Malik, Rainer; Pedersen, Ole Birger; Pelzer, Nadine; Penninx, Brenda W. J. H.; Ran, Caroline; Ridker, Paul M.; Rosendaal, Frits Richard; Sigurdardottir, Gudrun R.; Skogholt, Anne Heidi; Sveinsson, Olafur A.; Thorgeirsson, Thorgeir E.; Ullum, Henrik; Zwart, John Anker Henrik (Peer reviewed; Journal article, 2022)
      Migraine affects over a billion individuals worldwide but its genetic underpinning remains largely unknown. Here, we performed a genome-wide association study of 102,084 migraine cases and 771,257 controls and identified ...

    • HMG-CoA reductase is a potential therapeutic target for migraine: a mendelian randomization study 

      Qu, Kang; Li, Ming-Xi; Yu, Peng; Palotie, Aarno; Pressman, Alice; Belin, Andrea C.; Bjornsdottir, Anna; van den Maagdenberg, Arn M. J. M.; Harder, Aster V. E.; Winsvold, Bendik Kristoffer Slagsvold; Müller-Myhsok, Bertram; Cormand, Bru; Ran, Caroline; Northover, Carrie; Kubisch, Christian; van Duijn, Cornelia; Nyholt, Dale R.; Chasman, Daniel I.; Posthuma, Danielle; Lessel, Davor; Boomsma, Dorret I.; Hämäläinen, Eija; Kristoffersen, Espen Saxhaug; Cuenca-Leon, Ester; Davey-Smith, George; Terwindt, Gisela M.; Sigurdardottir, Gudrun R.; Bjornsdottir, Gyda; Hautakangas, Heidi; Stefansson, Hreinn; de Boer, Irene; Kaprio, Jaakko; Olesen, Jes; Zwart, John Anker Henrik; Stefansson, Kari; Ligthart, Lannie; Launer, Lenore; Pedersen, Linda Margareth; Kogelman, Lisette J. A.; Griffiths, Lyn R.; Ikram, M. Arfan; Wessman, Maija; Kaunisto, Mari; Hrafnsdottir, Maria G.; Hiekkala, Marjo; Järvelin, Marjo-Riitta; Dichgans, Martin; Pirinen, Matti; Kallela, Mikko; Kurki, Mitja; Chalmer, Mona A.; Pedersen, Nancy; Sveinsson, Olafur A.; Raitakari, Olli; Gormley, Padhraig; Pozo-Rosich, Patricia; Palta, Priit; Malik, Rainer; Kajanne, Risto; Børte, Sigrid; Magnusson, Sigurdur H.; Lehtimäki, Terho; Hansen, Thomas F; Thorgeirsson, Thorgeir E.; Freilinger, Tobias; Kurth, Tobias; Esko, Tonu; Anttila, Verneri; Artto, Ville; Wu, Bai-Hua; Shi, Miao; Dong, Ming (Peer reviewed; Journal article, 2024)
      Statins are thought to have positive effects on migraine but existing data are inconclusive. We aimed to evaluate the causal effect of such drugs on migraines using Mendelian randomization. We used four types of genetic ...

    • Proteogenomic Data Integration Reveals CXCL10 as a Potentially Downstream Causal Mediator for IL-6 Signaling on Atherosclerosis 

      Prapiadou, Savvina; Živković, Luka; Thorand, Barbara; George, Marc J.; Van Der Laan, Sander W; Malik, Rainer; Herder, Christian; Koenig, Wolfgang; Ueland, Thor; Kleveland, Ola; Aukrust, Pål; Gullestad, Lars; Bernhagen, Jürgen; Pasterkamp, Gerard; Peters, Annette; Hinogorani, Aroon D.; Rosand, Jonathan; Dichgans, Martin; Anderson, Christopher D.; Georgakis, Marios K. (Peer reviewed; Journal article, 2023)
      Background: Genetic and experimental studies support a causal involvement of IL-6 (interleukin-6) signaling in atheroprogression. Although trials targeting IL-6 signaling are underway, any benefits must be balanced against ...

    • Relationship between Blood Pressure and Incident Cardiovascular Disease: Linear and Nonlinear Mendelian Randomization Analyses 

      Malik, Rainer; Georgakis, Marios K.; Vujkovic, Marijana; Damrauer, Scott M.; Elliott, Paul; Karhunen, Ville; Giontella, Alice; Fava, Cristiano; Hellwege, Jacklyn N.; Shuey, Megan M.; Edwards, Todd L.; Rogne, Tormod; Åsvold, Bjørn Olav; Brumpton, Ben Michael; Burgess, Stephen; Dichgans, Martin; Gill, Dipender (Peer reviewed; Journal article, 2021)
      Observational studies exploring whether there is a nonlinear effect of blood pressure on cardiovascular disease (CVD) risk are hindered by confounding. This limitation can be overcome by leveraging randomly allocated genetic ...

    • Stroke genetics informs drug discovery and risk prediction across ancestries 

      Mishra, Aniket; Malik, Rainer; Hachiya, Tsuyoshi; Jürgenson, Tuuli; Namba, Shinichi; Posner, Daniel C.; Kamanu, Frederick K.; Koido, Masaru; Le Grand, Quentin; Shi, Mingyang; He, Yunye; Georgakis, Marios K.; Caro, Ilana; Krebs, Kristine; Liaw, Yi-Ching; Vaura, Felix C.; Lin, Kuang; Winsvold, Bendik K S; Srinivasasainagendra, Vinodh; Parodi, Livia; Bae, Hee-Joon; Chauhan, Ganesh; Tomppo, Liisa; Akinyemi, Rufus; Roshchupkin, Gennady V.; Habib, Naomi; Jee, Yon Ho; Thomassen, Jesper Qvist; Abedi, Vida; Cárcel-Márquez, Jara; Nygaard, Marianne; Leonard, Hampton L.; Yang, Chaojie; Yonova-Doing, Ekaterina; Knol, Maria J.; Lewis, Adam J.; Judy, Renae L.; Ago, Tetsuro; Amouyel, Philippe; Armstrong, Nicole D.; Bakker, Mark K.; Bartz, Traci M.; Bennett, David A.; Bis, Joshua C.; Bordes, Constance; Børte, Sigrid; Cain, Anael; Ridker, Paul M.; Cho, Kelly; Chen, Zhengming; Cruchaga, Carlos; Cole, John W.; de Jager, Phil L.; de Cid, Rafael; Endres, Matthias; Ferreira, Leslie E.; Geerlings, Mirjam I.; Gasca, Natalie C.; Gudnason, Vilmundur; Hata, Jun; He, Jing; Heath, Alicia K.; Ho, Yuk-Lam; Havulinna, Aki S.; Hopewell, Jemma C.; Hyacinth, Hyacinth I.; Inouye, Michael; Jacob, Mina A.; Jeon, Christina E.; Jern, Christina; Kamouchi, Masahiro; Keene, Keith L.; Kitazono, Takanari; Kittner, Steven J.; Konuma, Takahiro; Kumar, Amit; Lacaze, Paul; Launer, Lenore J.; Lee, Keon-Joo; Lepik, Kaido; Li, Jiang; Li, Liming; Manichaikul, Ani; Markus, Hugh S.; Marston, Nicholas A.; Meitinger, Thomas; Mitchell, Braxton D.; Montellano, Felipe A.; Morisaki, Takayuki; Mosley, Thomas H.; Nalls, Mike A.; Nordestgaard, Børge G; O'Donnell, Martin J.; Okada, Yukinori; Onland-Moret, N Charlotte; Ovbiagele, Bruce; Peters, Annette; Psaty, Bruce M.; Rich, Stephen S.; Rosand, Jonathan; Sabatine, Marc S.; Sacco, Ralph L.; Saleheen, Danish; Sandset, Else Charlotte; Salomaa, Veikko; Sargurupremraj, Muralidharan; Sasaki, Makoto; Satizabal, Claudia L.; Schmidt, Carsten O.; Shimizu, Atsushi; Smith, Nicholas L.; Sloane, Kelly L.; Sutoh, Yoichi; Sun, Yan V.; Tanno, Kozo; Tiedt, Steffen; Tatlisumak, Turgut; Torres-Aguila, Nuria P.; Tiwari, Hemant K.; Trégouët, David-Alexandre; Trompet, Stella; Tuladhar, Anil Man; Tybjærg-Hansen, Anne; van Vugt, Marion; Vibo, Riina; Verma, Shefali S.; Wiggins, Kerri L.; Wennberg, Patrik; Woo, Daniel; Wilson, Peter W F; Xu, Huichun; Yang, Qiong; Yoon, Kyungheon; Millwood, Iona Y.; Gieger, Christian; Ninomiya, Toshiharu; Grabe, Hans J.; Jukema, J Wouter; Rissanen, Ina L.; Strbian, Daniel; Kim, Young Jin; Chen, Pei-Hsin; Mayerhofer, Ernst; Howson, Joanna M M; Irvin, Marguerite R.; Adams, Hieab; Wassertheil-Smoller, Sylvia; Christensen, Kaare; Ikram, Mohammad A.; Rundek, Tatjana; Worrall, Bradford B.; Lathrop, G Mark; Riaz, Moeen; Simonsick, Eleanor M.; Kõrv, Janika; França, Paulo H C; Zand, Ramin; Prasad, Kameshwar; Frikke-Schmidt, Ruth; de Leeuw, Frank-Erik; Liman, Thomas; Haeusler, Karl Georg; Ruigrok, Ynte M.; Heuschmann, Peter Ulrich; Longstreth, W.T.; Jung, Keum Ji; Bastarache, Lisa; Paré, Guillaume; Damrauer, Scott M.; Chasman, Daniel I.; Rotter, Jerome I.; Anderson, Christopher D.; Zwart, John Anker Henrik; Niiranen, Teemu J.; Fornage, Myriam; Liaw, Yung-Po; Seshadri, Sudha; Fernández-Cadenas, Israel; Walters, Robin G.; Ruff, Christian T.; Owolabi, Mayowa O.; Huffman, Jennifer E.; Milani, Lili; Kamatani, Yoichiro; Dichgans, Martin; Debette, Stephanie (Peer reviewed; Journal article, 2022)
      Previous genome-wide association studies (GWASs) of stroke — the second leading cause of death worldwide — were conducted predominantly in populations of European ancestry1,2. Here, in cross-ancestry GWAS meta-analyses of ...