Browsing NTNU Open by Author "Madland, Eva"
Now showing items 1-9 of 9
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1H, 13C and 15N backbone and side-chain assignment of a carbohydrate binding module from a xylanase from Roseburia intestinalis
Madland, Eva; Kitaoku, Yoshihito; Sætrom, Gerd Inger; Leth, Maria Louise; Ejby, Morten; Hachem, Maher Abou; Aachmann, Finn Lillelund (Journal article; Peer reviewed, 2018)The N-terminal domain (residues 28–165) from the glycoside hydrolase family 10 from Roseburia intestinalis (RiCBMx), has been isotopically labeled and recombinantly expressed in Escherichia coli. Here we report 1H, 13C and ... -
Chemical Analysis and Anthelmintic Activity Against Teladorsagia Circumcincta of Nordic Bark Extracts In vitro
Athanasiadou, Spiridoula; Almvik, Marit; Hellström, Jarkko; Madland, Eva; Simic, Nebojsa; Steinshamn, Håvard (Peer reviewed; Journal article, 2021)Helminth parasitic infections are common in small ruminants in Norway; infection is usually treated with anthelmintic drugs, but anthelmintic resistance is an increasing problem. It is necessary to identify strategies to ... -
Class IV lasso peptides synergistically induce proliferation of cancer cells and sensitize them to doxorubicin
Madland, Eva; Felipe Guerrero-Garzón, Jaime; Zehl, Martin; Singh, Madhurendra; Rezaei, Shiva; Aachmann, Finn Lillelund; Courtade, Gaston; Urban, Ernst; Rückert, Christian; Busche, Tobias; Kalinowski, Jörn; Cao, Yan-Ru; Jiang, Yi; Jiang, Cheng-lin; Selivanova, Galina; Zotchev, Sergey (Peer reviewed; Journal article, 2020)Heterologous expression of a biosynthesis gene cluster from Amycolatopsis sp. resulted in the discovery of two unique class IV lasso peptides, felipeptins A1 and A2. A mixture of felipeptins stimulated proliferation of ... -
Extraction, Isolation and Structure Elucidation of Saponins from Herniaria incana
Madland, Eva (Master thesis, 2013)Species of the Herniaria genus have been reported to have several medicinal uses. Two of the species from this genus, Herniaria glabra and Herniaria hirsuta, have both been documented to contain saponins. This can explain ... -
A glycan receptor kinase facilitates intracellular accommodation of arbuscular mycorrhiza and symbiotic rhizobia in the legume Lotus japonicus
Kelly, Simon; Hansen, Simon B.; Rübsam, Henriette; Saake, Pia; Pedersen, Emil B.; Gysel, Kira; Madland, Eva; Wu, Shunliang; Wawra, Stephan; Reid, Dugald; Sullivan, John T.; Blahovska, Zuzana; Vinther, Maria; Muszynski, Artur; Azadi, Parastoo; Thygesen, Mikkel B.; Aachmann, Finn Lillelund; Ronson, Clive W.; Zuccaro, Alga; Andersen, Kasper R.; Radutoiu, Simona; Stougaard, Jens (Peer reviewed; Journal article, 2023)Receptors that distinguish the multitude of microbes surrounding plants in the environment enable dynamic responses to the biotic and abiotic conditions encountered. In this study, we identify and characterise a glycan ... -
Interactions between carbohydrate-binding modules and carbohydrates – An NMR study
Madland, Eva (Doctoral theses at NTNU;2020:346, Doctoral thesis, 2020)Protein-carbohydrate interactions are vital for all living organisms, whether they are plants, humans, bacteria or viruses. These macromolecular interactions are crucial for processes such as cell-cell communication, ... -
Molecular insight into a new low-affinity xylan binding module from the xylanolytic gut symbiont Roseburia intestinalis
Leth, Maria Louise; Ejby, Morten; Madland, Eva; Kitaoku, Yoshihito; Slotboom, Dirk J.; Guskov, Albert; Aachmann, Finn Lillelund; Hachem, Maher Abou (Peer reviewed; Journal article, 2019)Efficient capture of glycans, the prime metabolic resources in the human gut, confers a key competitive advantage for gut microbiota members equipped with extracellular glycoside hydrolases (GHs) to target these substrates. ... -
NMR and fluorescence spectroscopies reveal the preorganized binding site in family 14 carbohydrate-binding module from human chitotriosidase
Madland, Eva; Crasson, Oscar; Vandevenne, Marylene; Sørlie, Morten; Aachmann, Finn Lillelund (Journal article; Peer reviewed, 2019)Carbohydrate-binding modules (CBM) play important roles in targeting and increasing the concentration of carbohydrate active enzymes on their substrates. Using NMR to get the solution structure of CBM14, we can gain insight ... -
Structural and functional variation of chitin-binding domains of a lytic polysaccharide monooxygenase from Cellvibrio japonicus
Madland, Eva; Forsberg, Zarah; Wang, Yong; Lindorff-Larsen, Kresten; Niebisch, Axel; Modregger, Jan; Eijsink, Vincent; Aachmann, Finn Lillelund; Courtade, Gaston (Peer reviewed; Journal article, 2021)Among the extensive repertoire of carbohydrate-active enzymes, lytic polysaccharide monooxygenases (LPMOs) have a key role in recalcitrant biomass degradation. LPMOs are copper-dependent enzymes that catalyze oxidative ...