Browsing NTNU Open by Author "Mærk, Mali"
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Benzoic Acid-Inducible Gene Expression in Mycobacteria
Dragset, Marte Singsås; Barczak, Amy K.; Kannan, Nisha; Mærk, Mali; Flo, Trude Helen; Valla, Svein; Rubin, Eric J.; Steigedal, Magnus (Journal article; Peer reviewed, 2015)Conditional expression is a powerful tool to investigate the role of bacterial genes. Here, we adapt the Pseudomonas putida-derived positively regulated XylS/Pm expression system to control inducible gene expression in ... -
Bioinformatisk analyse og genetisk modifisering av karbohydratmetabolismen i Pseudomonas fluorescens, med fokus på alginatsyntese fra glukose
Mærk, Mali (Master thesis, 2006)Den sentrale karbohydratmetabolismen i Pseudomonas fluorescens, med vekt på opptak og metabolisme av glukose, ble forsøkt kartlagt ved litteraturstudier og bioinformatisk analyse av tilgjengelige genomsekvenser. Det ble ... -
Genome-wide Phenotypic Profiling Identifies and Categorizes Genes Required for Mycobacterial Low Iron Fitness
Dragset, Marte Singsås; Ioerger, Thomas R.; Zhang, Yanjia; Mærk, Mali; Ginbot, Zekarias; Flo, Trude Helen; Rubin, Eric J; Steigedal, Magnus (Journal article; Peer reviewed, 2019)Iron is vital for nearly all living organisms, but during infection, not readily available to pathogens. Infectious bacteria therefore depend on specialized mechanisms to survive when iron is limited. These mechanisms make ... -
Identification of Regulatory Genes and Metabolic Processes Important for Alginate Biosynthesis in Azotobacter vinelandii by Screening of a Transposon Insertion Mutant Library
Mærk, Mali; Jakobsen, Øyvind Mejdell; Sletta, Håvard; Klinkenberg, Geir; Tøndervik, Anne; Ellingsen, Trond Erling; Valla, Svein; Ertesvåg, Helga (Journal article; Peer reviewed, 2020)Azotobacter vinelandii produces the biopolymer alginate, which has a wide range of industrial and pharmaceutical applications. A random transposon insertion mutant library was constructed from A. vinelandii ATCC12518Tc in ... -
Looking for the Big Picture:Genome-Based Approaches to Improve Alginate Production in Azotobacter vinelandii
Mærk, Mali (Doktoravhandlinger ved NTNU, 1503-8181; 2014:18, Doctoral thesis, 2014)Alginates are commercially important polysaccharides with a wide range of industrial and technological applications. Polymer chain length and monomer distribution greatly affect the material properties, which makes different ... -
Safety in numbers: multiple occurrences of highly similar homologs among Azotobacter vinelandii carbohydrate metabolism proteins probably confer adaptive benefits
Mærk, Mali; Johansen, Jostein; Ertesvåg, Helga; Drabløs, Finn; Valla, Svein (Journal article; Peer reviewed, 2014)Background Gene duplication and horizontal gene transfer are common processes in bacterial and archaeal genomes, and are generally assumed to result in either diversification or loss of the redundant gene copies. However, ...